Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Luisa C. López-Cara"'
1
Akademický článek
Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines
Autor: Pablo García-Molina, Alberto Sola-Leyva, Pilar M. Luque-Navarro, Alejandro Laso, Pablo Ríos-Marco, Antonio Ríos, Daniela Lanari, Archimede Torretta, Emilio Parisini, Luisa C. López-Cara, Carmen Marco, María P. Carrasco-Jiménez
Publikováno v: Pharmaceutics, Vol 14, Iss 2, p 426 (2022)
A large number of different types of cancer have been shown to be associated with an abnormal metabolism of phosphatidylcholine (PC), the main component of eukaryotic cell membranes. Indeed, the overexpression of choline kinase α1 (ChoKα1), the enz
Externí odkaz: https://doaj.org/article/52feff0c502f4225b33e95e0ef1959fd
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2
Akademický článek
Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells
Autor: Alberto Ramírez, Ana Conejo-García, Carmen Griñán-Lisón, Luisa C. López-Cara, Gema Jiménez, Joaquín M. Campos, Juan A. Marchal, Houria Boulaiz
Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)
New treatment modalities are urgently needed to better manage advanced breast cancer. Combination therapies are usually more effective than monotherapy. In this context, the use of cyclic and acyclic O,N-acetals derivative compounds in combination wi
Externí odkaz: https://doaj.org/article/a7c46f51a3af4717b6c4c1c579b1417a
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3
Akademický článek
Biomimetic Magnetic Nanocarriers Drive Choline Kinase Alpha Inhibitor inside Cancer Cells for Combined Chemo-Hyperthermia Therapy
Autor: Ylenia Jabalera, Alberto Sola-Leyva, Ana Peigneux, Federica Vurro, Guillermo R. Iglesias, Jesus Vilchez-Garcia, Inmaculada Pérez-Prieto, Francisco J. Aguilar-Troyano, Luisa C. López-Cara, María P. Carrasco-Jiménez, Concepcion Jimenez-Lopez
Publikováno v: Pharmaceutics, Vol 11, Iss 8, p 408 (2019)
Choline kinase α1 (ChoKα1) has become an excellent antitumor target. Among all the inhibitors synthetized, the new compound Ff35 shows an excellent capacity to inhibit ChoKα1 activity. However, soluble Ff35 is also capable of inhibiting choline up
Externí odkaz: https://doaj.org/article/104aaca826274460a72d84e70e599386
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4
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Autor: Chaim Putterman, Peter Runge, Raquel Furtado, Angelo D'Alessandro, Kari Alitalo, Rajesh Kumar Soni, Giada Mondanelli, Simone Moretti, Sarah Gehrke, Sangeetha Thangaswamy, Wanxia Li Tsai, Giorgia Manni, Grégoire Lauvau, Sheila Spada, Laura Santambrogio, Massimo Gadina, Silvia C. Formenti, Cornelia Halin, Sandra Demaria, Marc Veldhoen, Cristina C. Clement, Roccaldo Sardella, Amanda P. Beck, Samantha A. Chalmers, Francesca Fallarino, Ursula Grohmann, Luisa C. López Cara, Jorge Arasa, Mihaela Skobe, Roberta Galarini, Antonio Macchiarulo, Marco Gargaro, Federica Ianni, Ruben Fernandez-Rodriguez, Sinem Karaman
Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The work was supported by the following grants: NIH-AG045223 and NIH-AI137198 to L.S.; the Swiss National Science Foundation, grant 310030_182528 to C.H.; Telethon GGP17094 and the Associazione Italiana per la Ricerca sul Cancro (AIRC; 19903) to F.F.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e8892c2cb7a5974dc461a6be74451
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5
NMR spectroscopic characterization of new 2,3-dihydro-1,3,4-thiadiazole derivatives
Autor: M Dora, Carrión, Luisa C, López-Cara, Mariem, Chayah, Duane, Choquesillo-Lazarte, Miguel A, Gallo, Antonio, Espinosa, Antonio, Entrena, M Encarnación, Camacho
Publikováno v: Magnetic resonance in chemistry : MRC. 50(7)
The (1) H and (13) C NMR resonances of twenty-seven 2,2-dimethyl-5-(2-nitrophenyl-5-substituted)-2,3-dihydro-1,3,4-thiadiazoles, and twenty-seven 3-acyl-5-(2-amino-5-substituted)-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazoles were assigned completely us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::133c28ce2c6a8eb0780f472a1a199320
https://pubmed.ncbi.nlm.nih.gov/22693150
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6
NMR and conformational studies of new 5-phenylpyrrole-carboxamide derivatives
Autor: Luisa C, López-Cara, M José, Pineda de las Infantas, M Dora, Carrión, M Encarnación, Camacho, Miguel A, Gallo, Antonio, Espinosa, Antonio, Entrena
Publikováno v: Magnetic resonance in chemistry : MRC. 47(12)
The 1H and 13C NMR resonances of 22 5-(5-substituted-2-nitrophenyl)-1H-pyrrole-2-carboxamides, 22 5-(5-substituted-2-aminophenyl)-1H-pyrrole-2-carboxamides, and 9 5-phenyl-1H-pyrrole-2-carboxamides were assigned completely using the concerted applica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f66f46614c359c8cdc428cd7d4b3375a
https://pubmed.ncbi.nlm.nih.gov/19821470
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7
Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors
Autor: Darío Acuña-Castroviejo, Antonio Entrena, Miguel A. Gallo, Luisa C. López Cara, Germaine Escames, M. Encarnación Camacho, M. Dora Carrión, Victor Tapias, Antonio Espinosa
Publikováno v: European journal of medicinal chemistry. 44(6)
We have previously described a series of 3-phenyl-4,5-dihydro-1H-pyrazole derivatives as moderately potent nNOS inhibitors. As a follow up of these studies, several new 5-phenyl-1H-pyrrole-2-carboxamide derivatives have been synthesized, and their bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d929c4b905d04633fcf85141a863df50
https://pubmed.ncbi.nlm.nih.gov/19117642
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8
1H, 13C NMR, X-ray and conformational studies of new 1-alkyl-3-benzoyl-pyrazole and 1-alkyl-3-benzoyl-pyrazoline derivatives
Autor: Luisa C, López-Cara, M Dora, Carrión, M Encarnación, Camacho, Miguel A, Gallo, Antonio, Espinosa, Duane, Choquesillo-Lazarte, Josefa M, Gonzalez-Pérez, Antonio, Entrena Guadix
Publikováno v: Magnetic resonance in chemistry : MRC. 46(9)
The (1)H and (13)C NMR resonances of 22 1-alkyl-pyrazole and 25 1-alkyl-pyrazoline derivatives were assigned completely using the concerted application of one- and two-dimensional experiments (DEPT, gs-HMQC and gs-HMBC). Nuclear Overhauser enhancemen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::877020d3ab8fdd41750acae7ff3068f9
https://pubmed.ncbi.nlm.nih.gov/18523976
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9
Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III)
Autor: M. Encarnación Camacho, Miguel A. Gallo, Luisa C. López Cara, Darío Acuña-Castroviejo, Germaine Escames, M. Dora Carrión, Antonio Espinosa, Antonio Entrena, Victor Tapias
Publikováno v: European journal of medicinal chemistry. 43(11)
We have previously described a series of 4,5-dihydro-1 H -pyrazole as moderately potent nNOS inhibitors. As a follow up of these studies, we report here the preparation and the preliminary evaluation of a series of 1-alkyl-3-benzoyl-4,5-dihydro-1 H -
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362a8ece60be6c783f0d67796ee92205
https://pubmed.ncbi.nlm.nih.gov/18325637
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