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Probing the Mechanism of Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase
Autor:
Antonio Del Rio Flores, David W. Kastner, Yongle Du, Maanasa Narayanamoorthy, Yuanbo Shen, Wenlong Cai, Vyshnavi Vennelakanti, Nicholas A. Zill, Luisa B. Dell, Rui Zhai, Heather J. Kulik, Wenjun Zhang
Publikováno v:
J Am Chem Soc
Journal of the American Chemical Society, vol 144, iss 13
Journal of the American Chemical Society, vol 144, iss 13
The isonitrile moiety is an electron-rich functionality that decorates various bioactive natural products isolated from diverse kingdoms of life. Isonitrile biosynthesis was restricted for over a decade to isonitrile synthases, a family of enzymes ca