Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Luisa, Ottobrini"'
Triple negative aggressive phenotype controlled by miR-135b and miR-365: new theranostics candidates
Autor:
Gloria Bertoli, Claudia Cava, Fabio Corsi, Francesca Piccotti, Cristina Martelli, Luisa Ottobrini, Valentina Vaira, Isabella Castiglioni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Triple negative breast cancer (TNBC) accounts for about a fifth of all breast cancers and includes a diverse group of cancers. The heterogeneity of TNBC and the lack of target receptors on the cell surface make it difficult to develop specif
Externí odkaz:
https://doaj.org/article/55a1477ce51945d6b0c6006989afd3e2
Autor:
Silvia Valtorta, Alessia Lo Dico, Isabella Raccagni, Cristina Martelli, Valentina Pieri, Paolo Rainone, Sergio Todde, Bastian Zinnhardt, Elisabetta De Bernardi, Angela Coliva, Letterio S. Politi, Thomas Viel, Andreas H. Jacobs, Rossella Galli, Luisa Ottobrini, Valentina Vaira, Rosa Maria Moresco
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glioblastoma (GBM) is a highly aggressive tumor of the brain. Despite the efforts, response to current therapies is poor and 2-years survival rate ranging from 6-12%. Here, we evaluated the preclinical efficacy of Metformin (MET) as add-on therapy to
Externí odkaz:
https://doaj.org/article/f75ed0e8ab8b4392986f68e1fb538abb
Autor:
Andrea Terrasi, Irene Bertolini, Cristina Martelli, Gabriella Gaudioso, Andrea Di Cristofori, Alessandra Maria Storaci, Miriam Formica, Silvano Bosari, Manuela Caroli, Luisa Ottobrini, Thomas Vaccari, Valentina Vaira
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 214-224 (2019)
Background: Cancer cells use specific V-ATPase subunits to activate oncogenic pathways. Therefore, we investigated V-ATPase deregulation in aggressive gliomas and associated signaling. Methods: V-ATPase genes expression and associated pathways were a
Externí odkaz:
https://doaj.org/article/a392076f517e441ebd67c82afe204e01
Autor:
Irene Bertolini, Andrea Terrasi, Cristina Martelli, Gabriella Gaudioso, Andrea Di Cristofori, Alessandra Maria Storaci, Miriam Formica, Paola Braidotti, Katia Todoerti, Stefano Ferrero, Manuela Caroli, Luisa Ottobrini, Thomas Vaccari, Valentina Vaira
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 225-235 (2019)
Background: The V-ATPase proton pump controls acidification of intra and extra-cellular milieu in both physiological and pathological conditions. We previously showed that some V-ATPase subunits are enriched in glioma stem cells and in patients with
Externí odkaz:
https://doaj.org/article/e152256e4a064914939aeafe0cc3e75c
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Hypoxia is a key driver of tumor adaptation promoting tumor progression and resistance to therapy. Hypoxia related pathways might represent attractive targets for the treatment of Glioblastoma Multiforme (GBM), that up to date is characterized by a p
Externí odkaz:
https://doaj.org/article/774df71ff8ae4c6892faaf3e3d57cf26
Autor:
Cecilia Diceglie, Gaia Maria Anelli, Cristina Martelli, Anais Serati, Alessia Lo Dico, Fabrizia Lisso, Francesca Parisi, Chiara Novielli, Renata Paleari, Irene Cetin, Luisa Ottobrini, Chiara Mandò
Publikováno v:
Nutrients, Vol 13, Iss 4, p 1303 (2021)
Maternal obesity and gestational diabetes mellitus (GDM) are increasing worldwide, representing risk factors for both mother and child short/long-term outcomes. Oxidative stress, lipotoxicity and altered autophagy have already been reported in obesit
Externí odkaz:
https://doaj.org/article/1d9cfbb496fb4b8f87e063d148e75479
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2217 (2021)
Chaperone-mediated autophagy (CMA) is a catabolic pathway fundamental for cell homeostasis, by which specific damaged or non-essential proteins are degraded. CMA activity has three main levels of regulation. The first regulatory level is based on the
Externí odkaz:
https://doaj.org/article/5a82d595bbd844419ec5cda19961e596
Autor:
Claudio Fenizia, Chiara Moltrasio, Luisa Ottobrini, Olga Utyro, Giovanni Genovese, Claudia Vanetti, Daria Trabattoni, Angelo V. Marzano
Publikováno v:
Journal of Investigative Dermatology.
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
RationaleThe activity of the transcription factor, hypoxia-inducible factor (HIF)-1α, is a common driver of a number of the pathways involved in the aggressiveness of glioblastomas (GBMs), and it has been suggested that the reduction in this activit
Externí odkaz:
https://doaj.org/article/58cbac6910224a34b593d5eeefa5998b
Autor:
Cristiana Perrotta, Davide Cervia, Ilaria Di Renzo, Claudia Moscheni, Maria Teresa Bassi, Lara Campana, Cristina Martelli, Elisabetta Catalani, Matteo Giovarelli, Silvia Zecchini, Marco Coazzoli, Annalisa Capobianco, Luisa Ottobrini, Giovanni Lucignani, Patrizia Rosa, Patrizia Rovere-Querini, Clara De Palma, Emilio Clementi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Tumor microenvironment is fundamental for cancer progression and chemoresistance. Among stromal cells tumor-associated macrophages (TAMs) represent the largest population of infiltrating inflammatory cells in malignant tumors, promoting their growth,
Externí odkaz:
https://doaj.org/article/13b8363310494d0fafd954d5dda2fc77