Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Luis del Peso"'
Autor:
Bárbara Acosta-Iborra, Ana Isabel Gil-Acero, Marta Sanz-Gómez, Yosra Berrouayel, Laura Puente-Santamaría, Maria Alieva, Luis del Peso, Benilde Jiménez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7669 (2024)
Knowledge of the molecular mechanisms that underlie the regulation of major adaptive responses to an unbalanced oxygen tension is central to understanding tissue homeostasis and disease. Hypoxia-inducible transcription factors (HIFs) coordinate chang
Externí odkaz:
https://doaj.org/article/b1cdc4ee54224204a50efcda67cf1cbd
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Molecular gene signatures are useful tools to characterize the physiological state of cell populations, but most have developed under a narrow range of conditions and cell types and are often restricted to a set of gene identities. Focusing
Externí odkaz:
https://doaj.org/article/0ba84e4594084cc6ad00a29c716d54b6
Autor:
Laura Puente-Santamaria, Lucia Sanchez-Gonzalez, Nuria Pescador, Oscar Martinez-Costa, Ricardo Ramos-Ruiz, Luis del Peso
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2229 (2022)
Integrating transcriptional profiles results in identifying gene expression signatures that are more robust than those obtained for individual datasets. However, a direct comparison of datasets derived from heterogeneous experimental conditions is pr
Externí odkaz:
https://doaj.org/article/f26c8d72594e4c949ea7511d4ae12387
Autor:
Asunción Fernández-Barral, Jose Luis Orgaz, Pablo Baquero, Zaheer Ali, Alberto Moreno, María Tiana, Valentí Gómez, Erica Riveiro-Falkenbach, Carmen Cañadas, Sandra Zazo, Corine Bertolotto, Irwin Davidson, Jose Luis Rodríguez-Peralto, Ignacio Palmero, Federico Rojo, Lasse Dahl Jensen, Luis del Peso, Benilde Jiménez
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 6, Pp 529-542 (2014)
Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells. Here we show that PEDF expression
Externí odkaz:
https://doaj.org/article/2fbad16e8fa34639b68b92e2466246f6
Autor:
Laura Arias-González, Inmaculada Moreno-Gimeno, Antonio Rubio del Campo, Serrano-Oviedo Leticia, María Llanos Valero, Azucena Esparís-Ogando, Miguel Ángel de la Cruz-Morcillo, Pedro Melgar-Rojas, Jesús García-Cano, Francisco José Cimas, María José Ruiz Hidalgo, Alfonso Prado, Juan Luis Callejas-Valera, Syong Hyun Nam-Cha, José Miguel Giménez-Bachs, Antonio S Salinas-Sánchez, Atanasio Pandiella, Luis del Peso, Ricardo Sánchez Prieto
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 6, Pp 649-659 (2013)
Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 is degraded thro
Externí odkaz:
https://doaj.org/article/7634b3ce804f4400989cd66c790679e9
Publikováno v:
Biomedicines, Vol 6, Iss 2, p 47 (2018)
Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge abou
Externí odkaz:
https://doaj.org/article/1a024d00610c4c6dbc952cc8bfd40f75
Autor:
Asunción Fernández-Barral, José Luis Orgaz, Valentí Gomez, Luis del Peso, María José Calzada, Benilde Jiménez
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32989 (2012)
Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor (SERPIN) superfamily, displays a potent antiangiogenic and antimetastatic activity in a broad range of tumor types. Melanocytes and low aggressive melanoma cells secr
Externí odkaz:
https://doaj.org/article/c04e6a442c744cb3b43b41298c359388
Autor:
Diego Villar, Amaya Ortiz-Barahona, Laura Gómez-Maldonado, Nuria Pescador, Fátima Sánchez-Cabo, Hubert Hackl, Benjamin A T Rodriguez, Zlatko Trajanoski, Ana Dopazo, Tim H M Huang, Pearlly S Yan, Luis Del Peso
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45708 (2012)
The transcriptional response driven by Hypoxia-inducible factor (HIF) is central to the adaptation to oxygen restriction. Despite recent characterization of genome-wide HIF DNA binding locations and hypoxia-regulated transcripts in different cell typ
Externí odkaz:
https://doaj.org/article/76a9b84e250f465abfeb1ef0d1b247d2
Autor:
Elisa Conde, Laura Alegre, Ignacio Blanco-Sánchez, David Sáenz-Morales, Elia Aguado-Fraile, Belén Ponte, Edurne Ramos, Ana Sáiz, Carlos Jiménez, Angel Ordoñez, Manuel López-Cabrera, Luis del Peso, Manuel O de Landázuri, Fernando Liaño, Rafael Selgas, Jose Antonio Sanchez-Tomero, María Laura García-Bermejo
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33258 (2012)
Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delays allograft function. Identification of factors that mediate protection and/or epithelium recovery could help to improve graft outcome. We studied the
Externí odkaz:
https://doaj.org/article/0c3676ea8427445d925b864830801ba1
Autor:
Elia Aguado-Fraile, Edurne Ramos, David Sáenz-Morales, Elisa Conde, Ignacio Blanco-Sánchez, Konstantinos Stamatakis, Luis del Peso, Edwin Cuppen, Bernhard Brüne, María Laura García Bermejo
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44305 (2012)
Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings. microRNA
Externí odkaz:
https://doaj.org/article/ce7f36bed0894effb40bdb93bc00c7e6