Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Luis Varela"'
Autor:
Sarah M. Mohr, Rafael Dai Pra, Maryann P. Platt, Viktor V. Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K. Merriman, Tamas L. Horvath, Sviatoslav N. Bagriantsev, Elena O. Gracheva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-
Externí odkaz:
https://doaj.org/article/85482d9133b24981b7be3db42e371392
Autor:
Nathan L. Price, Pablo Fernández-Tussy, Luis Varela, Magdalena P. Cardelo, Marya Shanabrough, Binod Aryal, Rafael de Cabo, Yajaira Suárez, Tamas L. Horvath, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in
Externí odkaz:
https://doaj.org/article/f1a854edd40041bf8676f1f698ab6e77
Autor:
Luis Varela-Rodríguez, Fernando Calzada, José Antonio Velázquez-Domínguez, Verónica Ivonne Hernández-Ramírez, Hugo Varela-Rodríguez, Elihú Bautista, Mayra Herrera-Martínez, Diana Laura Pichardo-Hernández, Rodrigo Daniel Castellanos-Mijangos, Bibiana Chávez-Munguía, Patricia Talamás-Rohana
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10633 (2024)
Several studies with kaempferol (KP) and linearolactone (LL) have demonstrated their antiparasitic activity. However, the toxicity of these treatments is unknown. Therefore, this study aimed to evaluate the possible toxicological effects of intraperi
Externí odkaz:
https://doaj.org/article/127cf975611b48538d35e39709dbf67b
Autor:
Jeanie De la torre Maslucan, Rosa Shimabukuro Maeki, Luis Varela Pinedo, Hever Hever Krüger Malpartida, Leandro Huayanay Falconí, Javier Cieza Zevallos, Miguel Gálvez Cano
Publikováno v:
Acta Médica Peruana, Vol 23, Iss 3 (2024)
Objetivo: validar la versión reducida (4 preguntas) de la escala de depresión geriátrica en pacientes adultos mayores. Materiales y métodos: estudio realizado entre setiembre 2002 y junio 2003, en 400 pacientes mayores de 60 años que no recibía
Externí odkaz:
https://doaj.org/article/b60d3aa07d974dc5b6a68867ea39b0b8
Autor:
Philipp Hammerschmidt, Sophie M. Steculorum, Cécile L. Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F. U. Klar, Corinna A. Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L. Horvath, Thorsten Hornemann, Susanne Brodesser, Jens C. Brüning
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscur
Externí odkaz:
https://doaj.org/article/0ef32131373a4665897de31f813f7c3c
Autor:
Carlos Escobar, Beatriz Palacios, Luis Varela, Martín Gutiérrez, Mai Duong, Hungta Chen, Nahila Justo, Javier Cid-Ruzafa, Ignacio Hernández, Phillip R. Hunt, Juan F. Delgado
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Aims To describe healthcare resource utilization (HCRU) of patients with heart failure with preserved (HFpEF), mildly reduced (HFmrEF), and reduced ejection fraction (HFrEF) in Spain. Methods Adults with ≥ 1 HF diagnosis and ≥ 1 year of
Externí odkaz:
https://doaj.org/article/1e346887883241cca4bd4817e2403de7
Autor:
Yalan Zhang, Luis Varela, Klara Szigeti-Buck, Adam Williams, Milan Stoiljkovic, Matija Šestan-Peša, Jorge Henao-Mejia, Pasquale D’Acunzo, Efrat Levy, Richard A. Flavell, Tamas L. Horvath, Leonard K. Kaczmarek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
How the activity of the neuronal Kv3.3 voltage-dependent channel is regulated is unclear. Here, the authors show that the known Kv3.3 channel complex with Hax1, which affects spinal cerebellar ataxia, regulates the enzyme Tank Binding Kinase 1, modul
Externí odkaz:
https://doaj.org/article/13d7eef65e4645d8b409edf85235aea3
Autor:
Héctor Bueno, Clara Goñi, Rafael Salguero-Bodes, Beatriz Palacios, Lourdes Vicent, Guillermo Moreno, Nicolás Rosillo, Luis Varela, Margarita Capel, Juan Delgado, Fernando Arribas, Manuel del Oro, Carmen Ortega, Jose L. Bernal
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundThere is scarce information on patients with secondary heart failure diagnosis (sHF). We aimed to compare the characteristics, burden, and outcomes of sHF with those with primary HF diagnosis (pHF).MethodsRetrospective, observational study
Externí odkaz:
https://doaj.org/article/4ae4c1b73738464293801569747b5fa9
Autor:
Carlos Escobar, Luis Varela, Beatriz Palacios, Margarita Capel, Antoni Sicras, Aram Sicras, Antonio Hormigo, Roberto Alcázar, Nicolás Manito, Manuel Botana
Publikováno v:
BMC Health Services Research, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Increasing the knowledge about heart failure (HF) costs and their determinants is important to ascertain how HF management can be optimized, leading to a significant decrease of HF costs. This study evaluated the cumulative costs
Externí odkaz:
https://doaj.org/article/44057c7e20004cb2809050bb5c90f430
Autor:
Luis Varela-Rodríguez, Blanca Sánchez-Ramírez, Verónica Ivonne Hernández-Ramírez, Hugo Varela-Rodríguez, Rodrigo Daniel Castellanos-Mijangos, Carmen González-Horta, Bibiana Chávez-Munguía, Patricia Talamás-Rohana
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-16 (2020)
Abstract Background Ovarian cancer is the leading cause of mortality among malignant gynecological tumors. Surgical resection and chemotherapy with intravenous platinum/taxanes drugs are the treatments of choice, with little effectiveness in later st
Externí odkaz:
https://doaj.org/article/745a555c84eb4a168742b7ecbbd9aef8