Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Luis T. da Costa"'
Publikováno v:
Proceedings of the National Academy of Sciences. 95:2509-2514
Recombinant adenoviruses provide a versatile system for gene expression studies and therapeutic applications. We report herein a strategy that simplifies the generation and production of such viruses. A recombinant adenoviral plasmid is generated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c700363b1d604727bcbaa8ba86796781
https://doi.org/10.1073/pnas.95.5.2509
https://doi.org/10.1073/pnas.95.5.2509
Autor:
Jian Yu, Kenneth W. Kinzler, Steve Laken, Andrew B. Sparks, Luis T. da Costa, Tong-Chuan He, Bert Vogelstein, Patrice J. Morin, Kornelia Polyak
Publikováno v:
Oncogene. 18(35)
The majority of human colorectal cancers have elevated beta-catenin/TCF regulated transcription due to either inactivating mutations of the APC tumor suppressor gene or activating mutations of beta-catenin. Surprisingly, one commonly used colorectal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a169fd1b5cf6d6dbd9b732a44e7319
https://pubmed.ncbi.nlm.nih.gov/10490837
https://pubmed.ncbi.nlm.nih.gov/10490837
Autor:
Kenneth W. Kinzler, Christoph Lengauer, Daniel P. Cahill, Bert Vogelstein, Eleanor B. Carson-Walter, Luis T. da Costa
Publikováno v:
Genomics. 58(2)
Aneuploidy is a characteristic of the majority of human cancers, and recent work has suggested that mitotic checkpoint defects play a role in its development. To further explore this issue, we isolated a novel human gene, MAD2B (MAD2L2), which is hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66915eb97e345c2e54edb524debf1c3
https://pubmed.ncbi.nlm.nih.gov/10366450
https://pubmed.ncbi.nlm.nih.gov/10366450
Autor:
Heiko Hermeking, Leigh Zawel, Bert Vogelstein, Luis T. da Costa, Andrew B. Sparks, Patrice J. Morin, Kenneth W. Kinzler, Carlo Rago, Tong-Chuan He
Publikováno v:
Science (New York, N.Y.). 281(5382)
The adenomatous polyposis coli gene ( APC ) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of β-catenin, which then binds T cell factor–4 (Tcf-4), causing increased transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b91bc55efeb53f013fda0493cbfcec
https://pubmed.ncbi.nlm.nih.gov/9750112
https://pubmed.ncbi.nlm.nih.gov/9750112
Autor:
Charles J. Yeo, Ester Rozenblum, Mieke Schutte, Aryeh Fischer, Luis T. da Costa, Scott E. Kern, Christopher A. Moskaluk, C. L. Weinstein, A. T. M. Shamsul Hoque, Ralph H. Hruban, Stephan A. Hahn
Publikováno v:
Science (New York, N.Y.). 271(5247)
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004c327be31d088df91f58d5588fe3c7
https://pubmed.ncbi.nlm.nih.gov/8553063
https://pubmed.ncbi.nlm.nih.gov/8553063
Autor:
Ester Rozenblum, Jeffrey M. Trent, Xiaoping Guan, Mieke Schutte, Christopher A. Moskaluk, Michael L. Bittner, Paul S. Meltzer, Luis T. da Costa, Scott E. Kern, Pieter J. de Jong
Publikováno v:
Nucleic acids research. 23(20)
We present a method for the isolation of YAC insert sequences by representational difference analysis (RDA). To achieve maximal representation of the sequences, the amplicons were generated from a Mbol digestion product. RDA was performed using a 970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134da41772eb19b1f4b436432f7a03ba
https://pubmed.ncbi.nlm.nih.gov/7479076
https://pubmed.ncbi.nlm.nih.gov/7479076
Autor:
Bert Vogelstein, Sanford D. Markowitz, Kenneth W. Kinzler, Stanley R. Hamilton, Albert de la Chapelle, Antero G. So, Luis T. da Costa, James K V Willson, Bo Liu, Wafik S. El-Deiry, Kathleen M. Downey
Publikováno v:
Nature Genetics. 9:10-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d678281748c191addd92f56f8edf9d7d
https://doi.org/10.1038/ng0195-10
https://doi.org/10.1038/ng0195-10
Autor:
He, Tong-Chuan, Sparks, Andrew B., Rago, Carlo, Hermeking, Heiko, Zawel, Leigh, Costa, Luis T. da, Morin, Patrice J., Vogelstein, Bert, Kinzler, Kenneth W.
Publikováno v:
Science. 9/4/1998, Vol. 281 Issue 5382, p1509-1512. 4p. 7 Black and White Photographs, 2 Diagrams, 6 Graphs.
Autor:
Hahn, Stephan A., Schutte, Mieke
Publikováno v:
Science. 1/19/1996, Vol. 271 Issue 5247, p350. 4p. 1 Black and White Photograph, 1 Diagram, 1 Chart.