Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Luis Sendra"'
Safe Procedure for Efficient Hydrodynamic Gene Transfer to Isolated Porcine Liver in Transplantation
Autor:
Luis Sendra, Mireia Navasquillo, Eva M. Montalvá, David Calatayud, Judith Pérez-Rojas, Javier Maupoey, Paula Carmona, Iratxe Zarragoikoetxea, Marta López-Cantero, María José Herrero, Salvador F. Aliño, Rafael López-Andújar
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1491 (2024)
Although calcineurin inhibitors are very effective as immunosuppressants in organ transplantation, complete graft acceptance remains as a challenge. Transfer of genes with immunosuppressant functions could contribute to improving the clinical evoluti
Externí odkaz:
https://doaj.org/article/288c356a50d349339817b1e910604e69
Autor:
Andrea Urtasun, Gladys G. Olivera, Luis Sendra, Salvador F. Aliño, Pablo Berlanga, Pablo Gargallo, David Hervás, Julia Balaguer, Antonio Juan-Ribelles, María del Mar Andrés, Adela Cañete, María José Herrero
Publikováno v:
Cancers, Vol 15, Iss 5, p 1424 (2023)
Background: Pharmacogenetics is a personalized medicine tool that aims to optimize treatments by adapting them to each individual’s genetics, maximizing their efficacy while minimizing their toxicity. Infants with cancer are especially vulnerable,
Externí odkaz:
https://doaj.org/article/6b4044fc3f064f83a27c881d8e61f0f7
Autor:
Manuel Fernández-Delgado, Luis Sendra, María José Herrero, Gladys G. Olivera-Pasquini, Alexander Batista-Duharte, Salvador F. Aliño
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5839 (2022)
Therapeutic oligonucleotides have achieved great clinical interest since their approval as drug agents by regulatory agencies but their access and distribution in blood cells are not completely known. We evaluated by flow cytometry the ability of sho
Externí odkaz:
https://doaj.org/article/e5e867a8e34349a196d20988917b99b5
Autor:
Luis Sendra, Gladys G. Olivera, Rafael López-Andújar, Cristina Serrano, Luis E. Rojas, Eva María Montalvá, María José Herrero, Salvador F. Aliño
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 354 (2022)
Some gene polymorphisms have been previously associated individually with tacrolimus efficacy and toxicity, but no long-term study to determine the role of pharmacogene variants in the clinical evolution of liver-transplanted patients has been addres
Externí odkaz:
https://doaj.org/article/ef4c0928c608413686ce06ae87694258
Autor:
Gladys G. Olivera, Andrea Urtasun, Luis Sendra, Salvador F. Aliño, Yania Yáñez, Vanessa Segura, Pablo Gargallo, Pablo Berlanga, Victoria Castel, Adela Cañete, María José Herrero
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9815 (2021)
Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients’ clinical management in order to tailor their therapies as much as possible, with the aim of maximizing effic
Externí odkaz:
https://doaj.org/article/a9d908f604834a96b61ab68f587d52cc
Autor:
Luis Sendra, María José Herrero, Eva María Montalvá, Inmaculada Noguera, Francisco Orbis, Ana Díaz, Rafael Fernández-Delgado, Rafael López-Andújar, Salvador F Aliño
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224568 (2019)
AIM:Liver transplantation is the only curative strategy for final stage liver diseases. Despite the great advances achieved during the last 20 years, the recipient immune response after transplantation is not entirely controlled. This results in high
Externí odkaz:
https://doaj.org/article/7eec1eda427f4a9c9059c52930d2be22
Autor:
Alexander Batista-Duharte, Luis Sendra, Maria José Herrero, Deivys Leandro Portuondo, Damiana Téllez-Martínez, Gladys Olivera, Manuel Fernández-Delgado, Beatriz Javega, Guadalupe Herrera, Alicia Martínez, Paulo Inacio Costa, Iracilda Zeppone Carlos, Salvador Francisco Aliño
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3470 (2021)
Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells (Tregs) to improve immunogenicit
Externí odkaz:
https://doaj.org/article/411675bf15f04d57801bedf7f91a3bad
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 281 (2021)
Vector design and its characterization is an area of great interest in current vaccine research. In this article, we have formulated and characterized a multicompartmental lipopolyplex, which associates multiple liposomes and polyplexes in the same c
Externí odkaz:
https://doaj.org/article/c4d6427a3c0048b88e8b461fcb4c5709
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 551 (2021)
Background: Mitochondrial DNA (mtDNA) diseases are a group of maternally inherited genetic disorders caused by a lack of energy production. Currently, mtDNA diseases have a poor prognosis and no known cure. The chance to have unaffected offspring wit
Externí odkaz:
https://doaj.org/article/9b596620ee0f4f19a4a93084e691cf2e
Autor:
Luis Sendra, Antonio Miguel, M. Carmen Navarro-Plaza, María José Herrero, José de la Higuera, Consuelo Cháfer-Pericás, Elena Aznar, M. Dolores Marcos, Ramón Martínez-Máñez, Luis Alfonso Rojas, Ramón Alemany, Salvador F. Aliño
Publikováno v:
Nanomaterials, Vol 10, Iss 6, p 1183 (2020)
Oncolytic adenoviruses are a therapeutic alternative to treat cancer based on their ability to replicate selectively in tumor cells. However, their use is limited mainly by the neutralizing antibody (Nab) immune response that prevents repeated dosing
Externí odkaz:
https://doaj.org/article/6dc36feecbd949959b629ae8ccdaccc4