Výsledky vyhledávání - "Luis Roberto Gueto-Tettay"

A PM7 dynamic residue-ligand interactions energy landscape of the BACE1 inhibitory pathway by hydroxyethylamine compounds. Part I: The flap closure process

Autor: Alejandro Martinez-Consuegra, Joshua Zuchniarz, Carlos Gueto-Tettay, Luis Roberto Gueto-Tettay, Juan Carlos Drosos-Ramirez

Publikováno v: Journal of molecular graphicsmodelling. 76

BACE1 is an enzyme of scientific interest because it participates in the progression of Alzheimer’s disease. Hydroxyethylamines (HEAs) are a family of compounds which exhibit inhibitory activity toward BACE1 at a nanomolar level, favorable pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4530de30828fd6003300afceb57210e
https://pubmed.ncbi.nlm.nih.gov/28746905

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A molecular dynamics study of the BACE1 conformational change from Apo to closed form induced by hydroxyethylamine derived compounds

Autor: Yeyson Fortich-Seca, Carlos Gueto-Tettay, Joshua Zuchniarz, Luis Roberto Gueto-Tettay, Juan Carlos Drosos-Ramirez

Publikováno v: Journal of molecular graphicsmodelling. 70

BACE1 is an aspartyl protease which is a therapeutic target for Alzheimer's disease (AD) because of its participation in the rate-limiting step in the production of Aβ-peptide, the accumulation of which produces senile plaques and, in turn, the neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6379cabce180cf27d5725c5944e8395
https://pubmed.ncbi.nlm.nih.gov/27750187

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