Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Luis P. Kuschel"'
Autor:
Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas
Externí odkaz:
https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479
Autor:
Luis P. Kuschel, Jürgen Hench, Stephan Frank, Ivana Bratic Hench, Elodie Girard, Maud Blanluet, Julien Masliah‐Planchon, Martin Misch, Julia Onken, Marcus Czabanka, Dongsheng Yuan, Sören Lukassen, Philipp Karau, Naveed Ishaque, Elisabeth G. Hain, Frank Heppner, Ahmed Idbaih, Nikolaus Behr, Christoph Harms, David Capper, Philipp Euskirchen
Publikováno v:
Neuropathology and Applied Neurobiology. 49
DNA methylation-based classification of cancer provides a comprehensive molecular approach to diagnose tumours. In fact, DNA methylation profiling of human brain tumours already profoundly impacts clinical neuro-oncology. However, current implementat
Autor:
Iver A. Langmoen, Einar O. Vik-Mo, Luna Djirackor, Luis P. Kuschel, Pitt Niehusmann, Henning Leske, Jens Pahnke, Bernt J. Due-Tønnessen, Philipp Euskirchen, David Capper, Skarphedinn Halldorsson, Cecilie Sandberg
Publikováno v:
Neuro-oncology Advances
Background Brain tumor surgery must balance the benefit of maximal resection against the risk of inflicting severe damage. The impact of increased resection is diagnosis-specific. However, the precise diagnosis is typically uncertain at surgery due t
Autor:
Konstantin Helmsauer, Matthias Fischer, David Torrents, M. E. Valieva, Philipp Euskirchen, F Hertwig, Katharina Kasack, Claudia Röefzaad, Heathcliff Dorado Garcia, Rocío Chamorro González, Luis P. Kuschel, Robert Schöpflin, Kerstin Haase, Stefan Mundlos, Angelika Eggert, Anton G. Henssen, Verena Heinrich, Yi Bei, Johannes Schulte, Richard Koche, Michael I. Robson, Elias Rodriguez-Fos, Montserrat Puiggròs, Carolina Rosswog, Annabell Szymansky, Salaheddine Ali, Jörn Tödling
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA. The exact amplicon structure has not been described thus far and the functional relevan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d9711a48d996498abf07dbc3f6d695
Autor:
Einar O. Vik-Mo, Henning Leske, Pitt Niehusmann, Philipp Euskirchen, Cecilie Sandberg, Jens Pahnke, Bernt J. Due-Tønnessen, Skarphedinn Halldorsson, Luna Djirackor, Luis P. Kuschel, Iver A. Langmoen
Publikováno v:
Neuro-Oncology
Background Clear identification of tumor subtype is the main predictor of patient outcome and ultimately what is considered an adequate level of surgical risk. At brain tumor resection, imaging modalities and intraoperative histology often give an am