Výsledky vyhledávání - "Luis Otávio B. Zamoner"

Cluster glycosides and heteroglycoclusters presented in alternative arrangements

Autor: Martin Rejzek, Andreza S. Figueredo, Ivone Carvalho, Luis Otávio B. Zamoner, Robert A. Field

Publikováno v: Tetrahedron Letters. 59:4405-4409

Multivalent carbohydrates, or glycoclusters, are useful tools to study glycan-lectin and glycan-enzyme recognition processes and have wide potential therapeutic applicability. Herein, we report the synthesis of novel glycoclusters presenting glucopyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdeea827706921dddb0781d1e03d0649
https://doi.org/10.1016/j.tetlet.2018.10.069

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Iminosugars: Effects of Stereochemistry, Ring Size, and N-Substituents on Glucosidase Activities

Autor: Valquiria Aragão-Leoneti, Ivone Carvalho, Luis Otávio B. Zamoner

Publikováno v: Pharmaceuticals, Vol 12, Iss 3, p 108 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Pharmaceuticals
Volume 12
Issue 3

N-substituted iminosugar analogues are potent inhibitors of glucosidases and glycosyltransferases with broad therapeutic applications, such as treatment of diabetes and Gaucher disease, immunosuppressive activities, and antibacterial and antiviral ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3192b011b824f9ae97178a4ba3b87635
https://www.mdpi.com/1424-8247/12/3/108

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CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory properties

Autor: Ivone Carvalho, Susimaire P. Mantoani, Luis Otávio B. Zamoner, Valquiria Aragão-Leoneti, Michael D. Rugen, Robert A. Field, Sergey A. Nepogodiev

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Protecting group-free synthesis of 1,2:5,6-di-anhydro-D-mannitol, followed by ring opening with propargylamine and subsequent ring closure produced a separable mix of piperidine N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and azepane N-propargyl 1,6-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cab21975d7d040d097f67e95d54fb4b
https://pubmed.ncbi.nlm.nih.gov/27160849

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Neamine and 2-deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic pain

Autor: Ivone Carvalho, Wiliam A. Prado, Luis Otávio B. Zamoner, A.C. Rossaneis, A.P. Corrado

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Objectives To assess the antinociceptive activity of the neomycin derivatives neamine and 2-deoxystreptamine following intraspinal administration in rats. Methods We used the tail-flick test and measured the threshold to mechanical stimulation in mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0bc6601e0c4edd090f24f672af7023

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