Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Luis Martinez‐Sobrido"'
Autor:
Michael S. Piepenbrink, Ahmed Magdy Khalil, Ana Chang, Ahmed Mostafa, Madhubanti Basu, Sanghita Sarkar, Simran Panjwani, Yaelyn H. Ha, Yao Ma, Chengjin Ye, Qian Wang, Todd J. Green, James L. Kizziah, Nathaniel B. Erdmann, Paul A. Goepfert, Lihong Liu, David D. Ho, Luis Martinez-Sobrido, Mark R. Walter, James J. Kobie
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. Ho
Externí odkaz:
https://doaj.org/article/fc93c8dbfeef47ec8f5ad7779811e16c
Autor:
Yuexiu Zhang, Michelle Chamblee, Jiayu Xu, Panke Qu, Mohamed M. Shamseldin, Sung J. Yoo, Jack Misny, Ilada Thongpan, Mahesh KC, Jesse M. Hall, Yash A. Gupta, John P. Evans, Mijia Lu, Chengjin Ye, Cheng Chih Hsu, Xueya Liang, Luis Martinez-Sobrido, Jacob S. Yount, Prosper N. Boyaka, Shan-Lu Liu, Purnima Dubey, Mark E. Peeples, Jianrong Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed highly efficacious, intranasal trivalent SARS-CoV-2 vaccine candidates (TVC) based on t
Externí odkaz:
https://doaj.org/article/8d4eee26f0fd4441806ce1eeeb848da8
Autor:
Akram Hegazy, Raya Soltane, Ahlam Alasiri, Islam Mostafa, Ahmed M. Metwaly, Ibrahim H. Eissa, Sara H. Mahmoud, Abdou Kamal Allayeh, Noura M. Abo Shama, Ahmed A. Khalil, Ramya S. Barre, Assem Mohamed El-Shazly, Mohamed A. Ali, Luis Martinez-Sobrido, Ahmed Mostafa
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-26 (2024)
Abstract Background The continuous evolution of drug-resistant influenza viruses highlights the necessity for repurposing naturally-derived and safe phytochemicals with anti-influenza activity as novel broad-spectrum anti-influenza medications. Metho
Externí odkaz:
https://doaj.org/article/459bd18dc3af4adf98e62c9bf91380b9
Autor:
Luis Martinez-Sobrido, Aitor Nogales
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10584 (2024)
Studying influenza A viruses (IAVs) requires secondary experimental procedures to detect the presence of the virus in infected cells or animals. The ability to generate recombinant (r)IAV using reverse genetics techniques has allowed investigators to
Externí odkaz:
https://doaj.org/article/0f44f72492424ad2a064f4d2ba6efe2f
Autor:
Benjamin Koch, Mahmoud Shehata, Christin Müller-Ruttloff, Shady A. Gouda, Nils Wetzstein, Sammy Patyna, Anica Scholz, Tobias Schmid, Ursula Dietrich, Christian Münch, John Ziebuhr, Helmut Geiger, Luis Martinez-Sobrido, Patrick C. Baer, Ahmed Mostafa, Stephan Pleschka
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionInfluenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during IAV infection, correlating with an increased mortal
Externí odkaz:
https://doaj.org/article/7ab24c6b07b54d538909b968359b9e77
Autor:
Michael Piepenbrink, Fatai Oladunni, Aitor Nogales, Ahmed M. Khalil, Theresa Fitzgerald, Thomas A. Hilimire, Madhubanti Basu, Christopher Fucile, David J. Topham, Alexander F. Rosenberg, Luis Martinez-Sobrido, James J. Kobie
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/3c461e3578174133b041510e0c25377b
Autor:
Daniel N. Streblow, Alec J. Hirsch, Jeffrey J. Stanton, Anne D. Lewis, Lois Colgin, Ann J. Hessell, Craig N. Kreklywich, Jessica L. Smith, William F. Sutton, David Chauvin, Jennifer Woo, Benjamin N. Bimber, Cierra N. LeBlanc, Sonia N. Acharya, Brian J. O’Roak, Harjinder Sardar, Mohammad M. Sajadi, Zahra R. Tehrani, Mark R. Walter, Luis Martinez-Sobrido, James J. Kobie, Rachel J. Reader, Katherine J. Olstad, Theodore R. Hobbs, Erica Ollmann Saphire, Sharon L. Schendel, Robert H. Carnahan, Jonas Knoch, Luis M. Branco, James E. Crowe, Koen K. A. Van Rompay, Phillip Lovalenti, Vu Truong, Donald N. Forthal, Nancy L. Haigwood
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to prevent infection and disease in rhesus macaques inoculated with
Externí odkaz:
https://doaj.org/article/8766bd1dd34746b3b375ff5406037cd7
Autor:
Haydar Witwit, Carlos Alberto Betancourt, Beatrice Cubitt, Roaa Khafaji, Heinrich Kowalski, Nathaniel Jackson, Chengjin Ye, Luis Martinez-Sobrido, Juan C. de la Torre
Publikováno v:
Viruses, Vol 16, Iss 9, p 1362 (2024)
The mammarenavirus matrix Z protein plays critical roles in virus assembly and cell egress. Meanwhile, heterotrimer complexes of a stable signal peptide (SSP) together with glycoprotein subunits GP1 and GP2, generated via co-and post-translational pr
Externí odkaz:
https://doaj.org/article/3cc8055eadb04d62a0b2a4c713f1089e
Autor:
Colwyn A. Headley, Shalini Gautam, Angelica Olmo‐Fontanez, Andreu Garcia‐Vilanova, Varun Dwivedi, Anwari Akhter, Alyssa Schami, Kevin Chiem, Russell Ault, Hao Zhang, Hong Cai, Alison Whigham, Jennifer Delgado, Amberlee Hicks, Philip S. Tsao, Jonathan Gelfond, Luis Martinez‐Sobrido, Yufeng Wang, Jordi B. Torrelles, Joanne Turner
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of CD4+ T lymphocytes in the elderly. In this proof of principle study, it is investigat
Externí odkaz:
https://doaj.org/article/155b08ee8fdd4021bcf7f433c2bfd1c0
Autor:
Amanda Watson, Pankil Shah, Doug Lee, Sitai Liang, Geeta Joshi, Ediri Metitiri, Wasim H Chowdhury, Dean Bacich, Peter Dube, Yan Xiang, Daniel Hanley, Luis Martinez-Sobrido, Ronald Rodriguez
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0307154 (2024)
The SARS-CoV-2 pandemic has caused unprecedented worldwide infections from persistent mutant variants with various degrees of infectivity and virulence. The elusiveness of a highly penetrant, worldwide vaccination strategy suggests that the complete
Externí odkaz:
https://doaj.org/article/52ccad43551c465794fad274ac679162