Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Luis M. Ruiz-Perez"'
Autor:
Ian H. Gilbert, Carlos Rodrigues, Marcel Kaiser, Silvia Orenes Lorente, Simon Jones, Luis M. Ruiz Perez, Aura Caldera, Julio A. Urbina, Carmen Jiménez, Reto Brun, Dolores Gonzalez Pacanowska, Wanderley da Souza, Ludovic Gros, Simon Cammerer, Juliany Cola Fernandes Rodrigues
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:4049-4061
There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cause these diseases is sterol biosynthesis. This pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3edf1815d5d344838ea0d03f2e54115
https://doi.org/10.1128/aac.00205-07
https://doi.org/10.1128/aac.00205-07
Autor:
Didier Pez, Dolores Gonzalez Pacanowska, Isabel Leal, Reto Brun, Cyrille Boussard, Fabio Zuccotto, Vanessa Yardley, Luis M. Ruiz Perez, Simon L. Croft, Ian H. Gilbert
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4693-4711
This paper describes the synthesis of 4'-substituted and 3',4'-disubstituted 5-benzyl-2,4-diaminopyrimidines as selective inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were then assayed against the recombinant parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d231415b7e868f4c91ae382d283371
https://doi.org/10.1016/j.bmc.2003.08.012
https://doi.org/10.1016/j.bmc.2003.08.012
Autor:
Antonio E. Vidal, Miriam Yagüe-Capilla, Blanca Martínez-Arribas, Daniel García-Caballero, Luis M. Ruiz-Pérez, Dolores González-Pacanowska
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Inosine triphosphate pyrophosphatases (ITPases) are ubiquitous house-cleaning enzymes that specifically recognize deaminated purine nucleotides and catalyze their hydrolytic cleavage. In this work, we have characterized the Trypanosoma bruce
Externí odkaz:
https://doaj.org/article/3983e70babb74e9aa1d7d73fb26957bd
Autor:
Frederick Annang, Guiomar Pérez-Moreno, Caridad Díaz, Victor González-Menéndez, Nuria de Pedro Montejo, José Pérez del Palacio, Paula Sánchez, Scott Tanghe, Ana Rodriguez, Ignacio Pérez-Victoria, Juan Cantizani, Luis M. Ruiz-Pérez, Olga Genilloud, Fernando Reyes, Francisca Vicente, Dolores González-Pacanowska
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background Malaria is a global health problem for which novel therapeutic compounds are needed. To this end, a recently published novel family of antiplasmodial macrolides, strasseriolides A–D, was herein subjected to in vivo efficacy stud
Externí odkaz:
https://doaj.org/article/19452ec86bc944d3bca7f97ac48433c7
Publikováno v:
ChemInform. 30
This paper describes the design and synthesis of potential inhibitors of Trypanosoma cruzi dihydrofolate reductase using a structure-based approach. A model of the structure of the T. cruzi enzyme was compared with the structure of the human enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::320a22fe41a6a445c5f6f5cd44fa4e0e
https://doi.org/10.1002/chin.199937167
https://doi.org/10.1002/chin.199937167
Autor:
Juana Carrero-Lérida, Marco Sealey-Cardona, Dolores Gonzalez Pacanowska, Carmen Jiménez-Jiménez, Luis M. Ruiz Perez, Julio A. Urbina
Publikováno v:
Molecular and biochemical parasitology. 160(1)
Trypanosomatids contain predominantly ergostane-based sterols, which differ from cholesterol, the main sterol in mammalian cells, in the presence of a methyl group in the 24 position. The methylation is initiated by S-adenosyl-L-methionine:Delta(24 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963bf8f4ed473a141e91f968d485c5e1
https://pubmed.ncbi.nlm.nih.gov/18485498
https://pubmed.ncbi.nlm.nih.gov/18485498
Autor:
Kate de Luca-Fradley, Simon L. Croft, Simon Cammerer, Dolores Gonzalez Pacanowska, Silvia Orenes Lorente, Vanessa Yardley, Carmen Jiménez, Rosario Gómez, Ian H. Gilbert, Julio A. Urbina, Luis M. Ruiz Perez
Publikováno v:
Bioorganicmedicinal chemistry. 13(10)
In this paper we describe the preparation of some biphenylquinuclidine derivatives and their evaluation as inhibitors of squalene synthase in order to explore their potential in the treatment of the parasitic diseases leishmaniasis and Chagas disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bb699e0c1bdb4cd229f8a694f8797f
https://pubmed.ncbi.nlm.nih.gov/15848765
https://pubmed.ncbi.nlm.nih.gov/15848765
Autor:
Ian H. Gilbert, Dolores González-Pacanowska, Luis M. Ruiz Perez, Didier Pez, Soghra Khabnadideh, Alexander Musso, Reto Brun
Publikováno v:
Bioorganicmedicinal chemistry. 13(7)
This paper describes the design, synthesis and evaluation of a series of 2,4-diaminoquinazolines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were designed by a generating virtual library of compounds and docking t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce8c70b193003964ca377dd2b1216e5
https://pubmed.ncbi.nlm.nih.gov/15755663
https://pubmed.ncbi.nlm.nih.gov/15755663
Autor:
Frederick Boye Annang, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Victor González-Menéndez, Jesús Martín, Thomas A. Mackenzie, Maria C. Ramos, Luis M. Ruiz-Pérez, Olga Genilloud, Dolores González-Pacanowska, Francisca Vicente, Fernando Reyes
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 492 (2023)
Memnoniella is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A Memnoniella dichroa CF-080171 extract was identified to exhibit potent activity against Plasmodium falciparum 3D7 and Trypanosoma cru
Externí odkaz:
https://doaj.org/article/2f3f742a6a834001a8f684d3477fc6ba
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(10)
This paper describes the design and synthesis of potential inhibitors of Trypanosoma cruzi dihydrofolate reductase using a structure-based approach. A model of the structure of the T. cruzi enzyme was compared with the structure of the human enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626ca47292372e3e5b56acc5b87a2e8e
https://pubmed.ncbi.nlm.nih.gov/10360757
https://pubmed.ncbi.nlm.nih.gov/10360757