Preclinical evaluation of strasseriolides A–D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251

Autor: Frederick Annang, Guiomar Pérez-Moreno, Caridad Díaz, Victor González-Menéndez, Nuria de Pedro Montejo, José Pérez del Palacio, Paula Sánchez, Scott Tanghe, Ana Rodriguez, Ignacio Pérez-Victoria, Juan Cantizani, Luis M. Ruiz-Pérez, Olga Genilloud, Fernando Reyes, Francisca Vicente, Dolores González-Pacanowska

Publikováno v: Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)

Abstract Background Malaria is a global health problem for which novel therapeutic compounds are needed. To this end, a recently published novel family of antiplasmodial macrolides, strasseriolides A–D, was herein subjected to in vivo efficacy stud

Externí odkaz: https://doaj.org/article/19452ec86bc944d3bca7f97ac48433c7

Low Competence and Developmental Motor Coordination Problems in Physical Education. [Baja competencia y problemas evolutivos de coordinación motriz en Educación Física].

Autor: Luis M. Ruiz-Pérez

Publikováno v: Revista Internacional de Ciencias del Deporte, Vol 14, Iss 52, Pp 97-100 (2018)

Currently there is no concern for clumsy children in physical education classes. Scientific and pedagogical literature do not show a great interest in children with motor coordination problems in Physical Education, this question is of more interest

Externí odkaz: https://doaj.org/article/e66373fc9a8a46e481c5166a3fc6db42

Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides

Autor: Antonio E. Vidal, Miriam Yagüe-Capilla, Blanca Martínez-Arribas, Daniel García-Caballero, Luis M. Ruiz-Pérez, Dolores González-Pacanowska

Publikováno v: Scientific reports. 12(1)

Inosine triphosphate pyrophosphatases (ITPases) are ubiquitous house-cleaning enzymes that specifically recognize deaminated purine nucleotides and catalyze their hydrolytic cleavage. In this work, we have characterized the Trypanosoma brucei ITPase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa36600c21bdda4f1827a43c8b30551
https://pubmed.ncbi.nlm.nih.gov/35436992

A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in Trypanosoma brucei

Autor: Cristina Bosch-Navarrete, Víctor M. Castillo-Acosta, Miriam Yagüe-Capilla, Luis M. Ruiz-Pérez, Dolores González-Pacanowska

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

The maintenance of deoxyribonucleotide triphosphate (dNTP) homeostasis through synthesis and degradation is critical for accurate genomic and mitochondrial DNA replication fidelity. Trypanosoma brucei makes use of both the salvage and de novo pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f2cbd857939d30fa8b4285d0d7e591
http://hdl.handle.net/10261/248201

Strasseriolides A−D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251

Autor: Juan Cantizani, Víctor González-Menéndez, Olga Genilloud, Luis M. Ruiz-Pérez, Duane Choquesillo-Lazarte, Ignacio Pérez-Victoria, Rodney Lacret, Frederick Annang, Guiomar Pérez-Moreno, Jesús Martín, Dolores González-Pacanowska, Fernando Reyes, Nuria de Pedro, Francisca Vicente

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

A novel family of four potent antimalarial macrolides, strasseriolides A−D (1−4), has been isolated from cultures of Strasseria geniculata CF-247251, a fungal strain obtained from plant tissues. The structures of these compounds, including their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387facdaed2cb93ff27d6ba4981e9da0
http://hdl.handle.net/10261/227562