Výsledky vyhledávání - "Luis M. Ruiz Perez"

Quinuclidine Derivatives as Potential Antiparasitics

Autor: Ian H. Gilbert, Carlos Rodrigues, Marcel Kaiser, Silvia Orenes Lorente, Simon Jones, Luis M. Ruiz Perez, Aura Caldera, Julio A. Urbina, Carmen Jiménez, Reto Brun, Dolores Gonzalez Pacanowska, Wanderley da Souza, Ludovic Gros, Simon Cammerer, Juliany Cola Fernandes Rodrigues

Publikováno v: Antimicrobial Agents and Chemotherapy. 51:4049-4061

There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cause these diseases is sterol biosynthesis. This pap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3edf1815d5d344838ea0d03f2e54115
https://doi.org/10.1128/aac.00205-07

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2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase

Autor: Didier Pez, Dolores Gonzalez Pacanowska, Isabel Leal, Reto Brun, Cyrille Boussard, Fabio Zuccotto, Vanessa Yardley, Luis M. Ruiz Perez, Simon L. Croft, Ian H. Gilbert

Publikováno v: Bioorganic & Medicinal Chemistry. 11:4693-4711

This paper describes the synthesis of 4'-substituted and 3',4'-disubstituted 5-benzyl-2,4-diaminopyrimidines as selective inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were then assayed against the recombinant parasite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d231415b7e868f4c91ae382d283371
https://doi.org/10.1016/j.bmc.2003.08.012

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ChemInform Abstract: The Structure-Based Design and Synthesis of Selective Inhibitors of Trypanosoma Cruzi Dihydrofolate Reductase

Autor: Luis M. Ruiz Perez, Dolores Gonzalez Pacanowska, Fabio Zuccotto, Reto Brun, Ian H. Gilbert

Publikováno v: ChemInform. 30

This paper describes the design and synthesis of potential inhibitors of Trypanosoma cruzi dihydrofolate reductase using a structure-based approach. A model of the structure of the T. cruzi enzyme was compared with the structure of the human enzyme.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::320a22fe41a6a445c5f6f5cd44fa4e0e
https://doi.org/10.1002/chin.199937167

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Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme

Autor: Juana Carrero-Lérida, Marco Sealey-Cardona, Dolores Gonzalez Pacanowska, Carmen Jiménez-Jiménez, Luis M. Ruiz Perez, Julio A. Urbina

Publikováno v: Molecular and biochemical parasitology. 160(1)

Trypanosomatids contain predominantly ergostane-based sterols, which differ from cholesterol, the main sterol in mammalian cells, in the presence of a methyl group in the 24 position. The methylation is initiated by S-adenosyl-L-methionine:Delta(24 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963bf8f4ed473a141e91f968d485c5e1
https://pubmed.ncbi.nlm.nih.gov/18485498

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Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa

Autor: Kate de Luca-Fradley, Simon L. Croft, Simon Cammerer, Dolores Gonzalez Pacanowska, Silvia Orenes Lorente, Vanessa Yardley, Carmen Jiménez, Rosario Gómez, Ian H. Gilbert, Julio A. Urbina, Luis M. Ruiz Perez

Publikováno v: Bioorganicmedicinal chemistry. 13(10)

In this paper we describe the preparation of some biphenylquinuclidine derivatives and their evaluation as inhibitors of squalene synthase in order to explore their potential in the treatment of the parasitic diseases leishmaniasis and Chagas disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bb699e0c1bdb4cd229f8a694f8797f
https://pubmed.ncbi.nlm.nih.gov/15848765

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Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase

Autor: Ian H. Gilbert, Dolores González-Pacanowska, Luis M. Ruiz Perez, Didier Pez, Soghra Khabnadideh, Alexander Musso, Reto Brun

Publikováno v: Bioorganicmedicinal chemistry. 13(7)

This paper describes the design, synthesis and evaluation of a series of 2,4-diaminoquinazolines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were designed by a generating virtual library of compounds and docking t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce8c70b193003964ca377dd2b1216e5
https://pubmed.ncbi.nlm.nih.gov/15755663

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The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase

Autor: Luis M. Ruiz Perez, Dolores Gonzalez Pacanowska, Reto Brun, Ian H. Gilbert, Fabio Zuccotto

Publikováno v: Bioorganicmedicinal chemistry letters. 9(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626ca47292372e3e5b56acc5b87a2e8e
https://pubmed.ncbi.nlm.nih.gov/10360757

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