Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice

Autor: Maria Cristina Ferreira de Sousa, Dennis Imhof, Kai Pascal Alexander Hänggeli, Ryan Choi, Matthew A. Hulverson, Samuel L.M. Arnold, Wesley C. Van Voorhis, Erkang Fan, Sánchez-Sánchez Roberto, Luis M. Ortega-Mora, Andrew Hemphill

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100553- (2024)

Toxoplasma gondii and Neospora caninum are major worldwide morbidity-causing pathogens. Bumped kinase inhibitors (BKIs) are a compound class that has been optimized to target the apicomplexan calcium-dependent protein kinase 1 (CDPK1) – and several

Externí odkaz: https://doaj.org/article/5d45770ad7984b1f80ca4e9a68cdce54

Serial Urinary C-C Motif Chemokine Ligand 14 and Risk of Persistent Severe Acute Kidney Injury

Autor: John R. Prowle, MD, Antonio Artigas, MD, Sean M. Bagshaw, MD, Lui G. Forni, PhD, Michael Heung, MD, Eric Hoste, PhD, Ostermann Marlies, PhD, Jay L. Koyner, MD, Lakmir Chawla, MD, J. Patrick Kampf, PhD, Thomas Kwan, PhD, Paul McPherson, PhD, John A. Kellum, MD, for the Sapphire and Ruby Investigators, K Kashani, A Al-Khafaji, T Ardiles, A Artigas, SM Bagshaw, M Bell, A Bihorac, R Birkhahn, CM Cely, LS Chawla, D Davison, T Feldkamp, LG Forni, MN Gong, KJ Gunnerson, M Haase, J Hackett, P Honore, EAJ Hoste, O Joannes-Boyau, M Joannidis, P Kim, JL Koyner, DT Laskowitz, ME Lissauer, G Marx, PA McCullough, S Mullaney, M Ostermann, T Rimmele, NI Shapiro, AD Shaw, J Shi, MG Walker, AM Sprague, JL Vincent, C Vinsonneau, L Wagner, RG Wilkerson, K Zacharowski, JA Kellum, Eric Hoste, Azra Bihora, Ali Al-Khafaji, Luis M. Ortega, Marlies Ostermann, Michael Haase, Kai Zacharowski, Richard Wunderink, Michael Heung, Kyle Gunnerson, Matthew Lissauer, Daniel Herr, Wesley H. Self, Jay L. Koyner, Patrick M. Honore, John R. Prowle, Danielle Davison, Antonio Artigas, Michael Joannidis, Rebecca Schroeder, Sevag Demirjian, Lui G. Forni, Luke Hodgson, Scott T. Wilber, Jennifer A. Frey, Ian Reilly, Jing Shi, J. Patrick Kampf, Thomas Kwan, Paul McPherson, John A. Kellum, Lakhmir S. Chawla

Publikováno v: Critical Care Explorations, Vol 5, Iss 3, p e0870 (2023)

OBJECTIVES:. To assess the added prognostic value of serial monitoring of urinary C-C motif chemokine ligand 14 (uCCL14) over that of single measurements, which have been shown to be prognostic for development of persistent severe acute kidney injury

Externí odkaz: https://doaj.org/article/b004de9a355f4faa8dc47d0fb5dc0636

In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts

Autor: Dennis Imhof, Nicoleta Anghel, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Hänggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 90-101 (2021)

Bumped kinase inhibitors (BKIs) target the apicomplexan calcium-dependent protein kinase 1 (CDPK1). BKI-1748, a 5-aminopyrazole-4-carboxamide compound when added to fibroblast cells concomitantly to the time of infection, inhibited proliferation of a

Externí odkaz: https://doaj.org/article/225361d65821483fab18631218d65033

Prevalence of Bovine Genital Campylobacteriosis, Associated Risk Factors and Spatial Distribution in Spanish Beef Cattle Based on Veterinary Laboratory Database Records

Autor: Nerea Pena-Fernández, David Cano-Terriza, Ignacio García-Bocanegra, Pilar Horcajo, Patricia Vázquez-Arbaizar, Darío Cleofé-Resta, Bárbara Pérez-Arroyo, Luis M. Ortega-Mora, Esther Collantes-Fernández

Publikováno v: Frontiers in Veterinary Science, Vol 8 (2021)

Bovine genital campylobacteriosis (BGC) is a sexually transmitted disease that causes early reproductive failure in natural breeding cattle that are managed extensively. The aim of this study was to assess the BGC prevalence in Spain from 2011 to 201

Externí odkaz: https://doaj.org/article/8fef176bb628439ab229632d864869d7

Exposure to Neospora spp. and Besnoitia spp. in wildlife from Israel

Autor: Monica L. Mazuz, Gema Alvarez-García, Roni King, Igor Savisky, Varda Shkap, Luis M. Ortega-Mora, Daniel Gutiérrez-Expósito

Publikováno v: International Journal for Parasitology: Parasites and Wildlife, Vol 7, Iss 3, Pp 317-321 (2018)

Neosporosis and besnoitiosis, caused by cyst-forming protozoa Neospora caninum and Besnoitia besnoiti, respectively, are parasitic infestations of livestock in Israel. These parasites cause significant economic losses in cattle due to reproductive an

Externí odkaz: https://doaj.org/article/17de4a3e3cd949be8af419bfd7e5e328