Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

Autor: Luis M. Molinos-Albert, Valérie Lorin, Valérie Monceaux, Sylvie Orr, Asma Essat, Jérémy Dufloo, Olivier Schwartz, Christine Rouzioux, Laurence Meyer, Laurent Hocqueloux, Asier Sáez-Cirión, Hugo Mouquet, ANRS VISCONTI Study Group

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

A rare sub-population of people living with HIV-1 experience long-lasting viral remission after interrupting antiretroviral therapy and are considered post-treatment controllers. Here the authors characterise the humoral immune response to HIV-1 in a

Externí odkaz: https://doaj.org/article/8c2bb6fda8ec43b2afd6cfd0349d774c

Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller

Autor: Valérie Lorin, Ignacio Fernández, Guillemette Masse-Ranson, Mélanie Bouvin-Pley, Luis M. Molinos-Albert, Cyril Planchais, Thierry Hieu, Gérard Péhau-Arnaudet, Dominik Hrebík, Giulia Girelli-Zubani, Oriane Fiquet, Florence Guivel-Benhassine, Rogier W. Sanders, Bruce D. Walker, Olivier Schwartz, Johannes F. Scheid, Jordan D. Dimitrov, Pavel Plevka, Martine Braibant, Michael S. Seaman, François Bontems, James P. Di Santo, Félix A. Rey, Hugo Mouquet

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2022, 219 (3), pp.e20212045. ⟨10.1084/jem.20212045⟩
Journal of experimental medicine, 219(3):e20212045. Rockefeller University Press

International audience; Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B cell lineages in a viremic controller, two of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fbdabc1785d2d76253a888d1c267a7
https://hal-pasteur.archives-ouvertes.fr/pasteur-03654254/file/jem_20212045.pdf

Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif

Autor: Jorge Carrillo, F.-Xabier Contreras, Eneritz Bilbao, Nuria Izquierdo-Useros, María Luisa Rodríguez de la Concepción, Bonaventura Clotet, Elisabet García, Luis M. Molinos-Albert, Silvia Marfil, Maier Lorizate, Julià Blanco, Pere J. Cardona, Jordi Villà-Freixa, Javier Martinez-Picado, Jon Ander Nieto-Garai, Luis Agulló, Cristina Vilaplana, Martin Floor

Publikováno v: Scientific Reports
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Recercat. Dipósit de la Recerca de Catalunya
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
RIUVic. Repositorio Institucional de la Universidad de Vic
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Altres ajuts: Programa HIVACAT, programa CERCA (Generalitat de Catalunya), Red Temática Cooperativa de Investigación en SIDA (RD12/0017/0002)), Govern Basc (IT838-13), Spanish Supercomputing Network (grant numbers BCV-2015-2-0009 and BCV-2016-2-000

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02946f15ff7ff4daac01aecfd40ea5ec
https://ddd.uab.cat/record/196312

Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals

Autor: Jorge Carrillo, Julià Blanco, Luis M. Molinos-Albert, Elisabet García, Silvia Marfil, Marta Curriu, Bonaventura Clotet, María Luisa Rodríguez de la Concepción

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Retrovirology
RIUVic. Repositorio Institucional de la Universidad de Vic

Background The MPER region of the HIV-1 envelope glycoprotein gp41 is targeted by broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic environment seems to hamper the elicitation of these antibodies in HIV infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ea66791efc29c5f41b16e40eba1265
https://doi.org/10.1186/1742-4690-11-44

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

Autor: Raziel A. Ordóñez, Gemma Farré, Abbey Evans, Barry R. O'Keefe, Richard M. Twyman, Bonaventura Clotet, Luis M. Molinos-Albert, J. Blanco, Evangelia Vamvaka, Paul Christou, Robin J. Shattock, Gurdev S. Khush, Anna Canela-Xandri, Teresa Capell, Jorge Carrillo

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Proceedings of the National Academy of Sciences of the United States of America
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Repositorio Abierto de la UdL
Universitad de Lleida
Proceedings of the National Academy of Sciences

Significance Our paper provides an approach for the durable deployment of anti-HIV agents in the developing world. We developed a transgenic rice line expressing three microbicidal proteins (the HIV-neutralizing antibody 2G12 and the lectins griffith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9ef2622b0ff428fb4de6d8f86a21da
http://hdl.handle.net/10459.1/65736