Zobrazeno 1 - 10
of 458
pro vyhledávání: '"Luis M. Garcia-Segura"'
Autor:
Alejandra Freire-Regatillo, Sonia Diaz-Pacheco, Laura M. Frago, María-Ángeles Arévalo, Jesús Argente, Luis M. Garcia-Segura, María L. de Ceballos, Julie A. Chowen
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2022)
The propensity to develop neurodegenerative diseases is influenced by diverse factors including genetic background, sex, lifestyle, including dietary habits and being overweight, and age. Indeed, with aging, there is an increased incidence of obesity
Externí odkaz:
https://doaj.org/article/56812f3cdf844165885607394b1cc21f
Autor:
Natalia Yanguas-Casás, Cristina Torres, Andrea Crespo-Castrillo, Sonia Diaz-Pacheco, Kiera Healy, Catherine Stanton, Julie A. Chowen, Luis M. Garcia-Segura, Maria Angeles Arevalo, John F. Cryan, Maria L. de Ceballos
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105495- (2021)
Long-term high-fat diet (HFD) consumption commonly leads to obesity, a major health concern of western societies and a risk factor for Alzheimer's disease (AD). Both conditions present glial activation and inflammation and show sex differences in the
Externí odkaz:
https://doaj.org/article/2c5dc5f23b354140a5fdb14f25bbac0d
Autor:
Ricardo Llorente, Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Julia Simon-Areces, Pedro Abellanas-Pérez, Marina Rivero-Aguilar, Jose M. Fernandez-Garcia, Helena Pinos, Luis M. Garcia-Segura, Paloma Collado, Daniela Grassi
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
G protein-coupled estrogen receptor (GPER) in the amygdala and the dorsal hippocampus mediates actions of estradiol on anxiety, social recognition and spatial memory. In addition, GPER participates in the estrogenic regulation of synaptic function in
Externí odkaz:
https://doaj.org/article/7093dac234cc45c5a3263d41d32b6be0
Autor:
Jose Luis Herrera, Lara Ordoñez-Gutierrez, Gemma Fabrias, Josefina Casas, Araceli Morales, Guadalberto Hernandez, Nieves G. Acosta, Covadonga Rodriguez, Luis Prieto-Valiente, Luis M. Garcia-Segura, Francisco G. Wandosell, Rafael Alonso
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
The formation of senile plaques through amyloid-β peptide (Aβ) aggregation is a hallmark of Alzheimer’s disease (AD). Irrespective of its actual role in the synaptic alterations and cognitive impairment associated with AD, different therapeutic a
Externí odkaz:
https://doaj.org/article/551aa58eb9c9446e8d9134592750d48f
Publikováno v:
Cells, Vol 10, Iss 8, p 1907 (2021)
Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of signaling pathways and homeostatic molecules. Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain n
Externí odkaz:
https://doaj.org/article/1632df81cbe7421c95275cb0ca31f081
Autor:
Jose L. Herrera, Lara Ordoñez-Gutierrez, Gemma Fabrias, Josefina Casas, Araceli Morales, Guadalberto Hernandez, Nieves G. Acosta, Covadonga Rodriguez, Luis Prieto-Valiente, Luis M. Garcia-Segura, Rafael Alonso, Francisco G. Wandosell
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Different dietary ratios of n−6/n−3 long-chain polyunsaturated fatty acids (LC-PUFAs) may alter brain lipid profile, neural activity, and brain cognitive function. To determine whether ovarian hormones influence the effect of diet on the brain, o
Externí odkaz:
https://doaj.org/article/bbf568c08dff486391e670f6eb1448ee
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment. In previous studies we have observed that the expression of different neu
Externí odkaz:
https://doaj.org/article/954628ed75c14dfa9651980155146574
Autor:
Laura M. Frago, Sandra Canelles, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Luis M. Garcia-Segura, Julie A. Chowen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
An excess of saturated fatty acids can be toxic for tissues, including the brain, and this has been associated with the progression of neurodegenerative diseases. Since palmitic acid (PA) is a free fatty acid that is abundant in the diet and circulat
Externí odkaz:
https://doaj.org/article/aadd113555394c3d9e81798cc15152cd
Publikováno v:
Frontiers in Aging Neuroscience, Vol 8 (2016)
Testosterone is a hormone that has been shown to confer neuroprotection from different insults affecting the central nervous system (CNS). Testosterone induces this protection by different mechanisms that include the activation of anti-apoptotic path
Externí odkaz:
https://doaj.org/article/5a3e2b93732c4e60b1f30c81fb524954
Autor:
Gaia Cermenati, Federico Abbiati, Solei Cermenati, Elisabetta Brioschi, Alessandro Volonterio, Guido Cavaletti, Enrique Saez, Emma De Fabiani, Maurizio Crestani, Luis M. Garcia-Segura, Roberto C. Melcangi, Donatella Caruso, Nico Mitro
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 2, Pp 300-310 (2012)
Diabetic peripheral neuropathy (DPN) is characterized by myelin abnormalities; however, the molecular mechanisms underlying such deficits remain obscure. To uncover the effects of diabetes on myelin alterations, we have analyzed myelin composition. I
Externí odkaz:
https://doaj.org/article/537aaa785a8d4d66a8124a6e26b33788