CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia

Autor: Jesús A. Andrés-San Román, Carmen Gordillo-Vázquez, Daniel Franco-Barranco, Laura Morato, Cecilia H. Fernández-Espartero, Gabriel Baonza, Antonio Tagua, Pablo Vicente-Munuera, Ana M. Palacios, María P. Gavilán, Fernando Martín-Belmonte, Valentina Annese, Pedro Gómez-Gálvez, Ignacio Arganda-Carreras, Luis M. Escudero

Publikováno v: Cell Reports: Methods, Vol 3, Iss 10, Pp 100597- (2023)

Summary: Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function of whole tissues. Co

Externí odkaz: https://doaj.org/article/ec2af9bd96934499a42ff5a2dff1b23c

Scutoids are a geometrical solution to three-dimensional packing of epithelia

Autor: Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Antonio Tagua, Cristina Forja, Ana M. Castro, Marta Letrán, Andrea Valencia-Expósito, Clara Grima, Marina Bermúdez-Gallardo, Óscar Serrano-Pérez-Higueras, Florencia Cavodeassi, Sol Sotillos, María D. Martín-Bermudo, Alberto Márquez, Javier Buceta, Luis M. Escudero

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Cell arrangement in the plane of epithelia is well studied, but its three-dimensional packing is largely unknown. Here the authors model curved epithelia and predict that cells adopt a geometrical shape they call “scutoid”, resulting in different

Externí odkaz: https://doaj.org/article/15120a6bf3ff476aacd098f151c1993e

Curvature in Biological Systems

Autor: Barbara Schamberger, Ricardo Ziege, Karine Anselme, Martine Ben Amar, Michał Bykowski, André P. G. Castro, Amaia Cipitria, Rhoslyn A. Coles, Rumiana Dimova, Michaela Eder, Sebastian Ehrig, Luis M. Escudero, Myfanwy E. Evans, Paulo R. Fernandes, Peter Fratzl, Liesbet Geris, Notburga Gierlinger, Edouard Hannezo, Aleš Iglič, Jacob J. K. Kirkensgaard, Philip Kollmannsberger, Łucja Kowalewska, Nicholas A. Kurniawan, Ioannis Papantoniou, Laurent Pieuchot, Tiago H. V. Pires, Lars D. Renner, Andrew O. Sageman‐Furnas, Gerd E. Schröder‐Turk, Anupam Sengupta, Vikas R. Sharma, Antonio Tagua, Caterina Tomba, Xavier Trepat, Sarah L. Waters, Edwina F. Yeo, Andreas Roschger, Cécile M. Bidan, John W. C. Dunlop

Publikováno v: Advanced Materials
Schamberger, B, Ziege, R, Anselme, K, Ben Amar, M, Bykowski, M, Castro, A P G, Cipitria, A, Coles, R A, Dimova, R, Eder, M, Ehrig, S, Escudero, L M, Evans, M E, Fernandes, P R, Fratzl, P, Geris, L, Gierlinger, N, Hannezo, E, Iglič, A, Kirkensgaard, J J K, Kollmannsberger, P, Kowalewska, Ł, Kurniawan, N A, Papantoniou, I, Pieuchot, L, Pires, T H V, Renner, L D, Sageman-Furnas, A O, Schröder-Turk, G E, Sengupta, A, Sharma, V R, Tagua, A, Tomba, C, Trepat, X, Waters, S L, Yeo, E F, Roschger, A, Bidan, C M & Dunlop, J W C 2023, ' Curvature in Biological Systems : Its Quantification, Emergence, and Implications across the Scales ', Advanced Materials, vol. 35, no. 13, 2206110 . https://doi.org/10.1002/adma.202206110

Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology is supported by numerous experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13fc88a450e0cd1e7ba7073cf40d1f2
http://www.scopus.com/inward/record.url?scp=85148379457&partnerID=8YFLogxK

The topology of vitronectin: A complementary feature for neuroblastoma risk classification based on computer‐aided detection

Autor: Rosa Noguera, Rebeca Burgos-Panadero, Pablo Vicente-Munuera, Inmaculada Noguera, Samuel Navarro, Luis M. Escudero

Publikováno v: International Journal of Cancer
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

Tumors are complex networks of constantly interacting elements: tumor cells, stromal cells, immune and stem cells, blood/lympathic vessels, nerve fibers and extracellular matrix components. These elements can influence their microenvironment through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c0ec063dbc9a8ee56c7d064522095b
http://europepmc.org/articles/PMC6899647

A Quantitative Biophysical Principle to Explain the 3D Cellular Connectivity in Curved Epithelia

Autor: Samira Anbari, Antonio Tagua, Rafael Robles, Pablo Vicente-Munuera, Pedro Gómez-Gálvez, Antonio Velasco, Valentina Annese, Luis M. Escudero, Clara I. Grima, Alberto Márquez, Ana M. Palacios, Javier Buceta, Carlos Capitán-Agudo, Carmen Gordillo-Vázquez

Publikováno v: SSRN Electronic Journal.

Epithelial cell organization and the mechanical stability of tissues are closely related. In this context, it has been recently shown that packing optimization in bended/folded epithelia is achieved by a surface tension energy minimization mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a83cfe9f8c81214d0fb7df8ccfd072f
https://doi.org/10.2139/ssrn.3834689