Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Luis M. Blancas‐Mejia"'
Autor:
Emily B Martin, Angela Williams, Craig Wooliver, R Eric Heidel, Sarah Adams, John Dunlap, Marina Ramirez-Alvarado, Luis M Blancas-Mejia, Ronald H Lands, Stephen J Kennel, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174152 (2017)
BACKGROUND:Monoclonal free light chain (LC) proteins are present in the circulation of patients with immunoproliferative disorders such as light chain (AL) amyloidosis and multiple myeloma (MM). Light chain-associated amyloid is a complex pathology c
Externí odkaz:
https://doaj.org/article/70a1e18a6c244bd991809094f706fbdf
Autor:
Daniel A. Franco, Seth Truran, Volkmar Weissig, Diana Guzman‐Villanueva, Nina Karamanova, Subhadip Senapati, Camelia Burciu, Marina Ramirez‐Alvarado, Luis M. Blancas‐Mejia, Stuart Lindsay, Parameswaran Hari, Raymond Q. Migrino
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 6 (2016)
BackgroundLight chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There
Externí odkaz:
https://doaj.org/article/4ccb7dc4ecb14d59b564340d43dae37b
Autor:
Nicole S. Clairmont, Tania Berrocal, Tanu Priya, Z. Beau Reneer, Avery Pong, Ted M. Ross, Matthew Walker, Yixuan J. Hou, Marsha L. Mason, Nuria Codina, Alexander Chen, Hong Peng, Luis M. Blancas-Mejia, Ryan Swanson, Jerry Chen, Tien-Ying Hsiang, Kevin Shengyang Yu, Michael Gale, Deborah H. Fuller, Carl Walkey, Jorgen Nelson, Renan Vergara, Anna Josephson-Day, Pamela J. Bjorkman, Wen Su, Daniel-Adriano Silva, Thomas W. Linsky, Ralph S. Baric, Masaya Mitsumoto, Hui-Ling Yen, Uland Y. Lau, Christopher O. Barnes, Javier Castellanos, Yu-Ru Lin, Katharina Esser-Nobis
Publikováno v:
Science (New York, N.y.)
Science
Science
A decoy to neutralize SARS-CoV-2 Many efforts to develop therapies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are focused on the interaction between the spike protein, which decorates the surface of the virus, and its host r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d062e3f45e8ec42c54eb1006e602c0b
https://doi.org/10.1126/science.abe0075
https://doi.org/10.1126/science.abe0075
Publikováno v:
Biochemistry
Little is known about the mechanism of amyloid assembly in immunoglobulin light chain (AL) amyloidosis, in contrast to other amyloid diseases. Early events in the aggregation pathway are especially important, as these soluble species could be cytotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa282e2baf1336f54378c55eab2cf4d5
https://doi.org/10.1021/acs.biochem.9b00311
https://doi.org/10.1021/acs.biochem.9b00311
Autor:
Anna Josephson-Day, Katharina Esser-Nobis, Tien-Ying Hsiang, Luis M. Blancas-Mejia, Daniel-Adriano Silva, Uland Y. Lau, Tanu Priya, Nicole S. Clairmont, Carl Walkey, Ryan Swanson, Jorgen Nelson, Michael Gale, Avery Pong, Kevin Shengyang Yu, Tania Berrocal, Hong Peng, Hui-Ling Yen, Javier Castellanos, Wen Su, Thomas W. Linsky, Yu-Ru Lin, Nuria Codina, Alexander Chen, Renan Vergara, Masaya Mitsumoto, Ralph S. Baric, Yixuan J. Hou, Jerry Chen, Matthew Walker, Marsha L. Mason
Publikováno v:
bioRxiv
There is an urgent need for the ability to rapidly develop effective countermeasures for emerging biological threats, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the ongoing coronavirus disease 2019 (COVID-19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898395e8cf9cfb1ee497f2a3224e8ad2
https://doi.org/10.1101/2020.08.03.231340
https://doi.org/10.1101/2020.08.03.231340
Autor:
Carl Walkey, Benjamin H. Dutzar, Ryan Swanson, Christie Mortales, Jerry Chen, Luis M. Blancas-Mejia, Justin Huard, Alexander Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundNL-201 is a potent, selective, and long-acting computationally designed alpha-independent agonist of the IL-2 and IL-15 receptors that is being developed as an immunotherapy for cancer. Downregulation of MHC class I (MHC-I) expression by tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e6966f1ad7566e0256e1c3bff82d64
https://doi.org/10.1136/jitc-2021-sitc2021.716
https://doi.org/10.1136/jitc-2021-sitc2021.716
Autor:
Emily B. Martin, Luis M. Blancas-Mejia, Jonathan S. Wall, Angela Williams, Marina Ramirez-Alvarado
Publikováno v:
Biophysical Chemistry. 230:89-98
It is now accepted that the ability of a protein to form amyloid fibrils could be associated both kinetic and thermodynamic protein folding parameters. A recent study from our laboratory using recombinant full-length (encompassing the variable and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496c352a61198f31b99ef8cee2e36935
https://doi.org/10.1016/j.bpc.2017.08.011
https://doi.org/10.1016/j.bpc.2017.08.011
Autor:
Chad M. Rienstra, Luis M. Blancas-Mejia, Dennis W. Piehl, Stephen J. Kennel, Marina Ramirez-Alvarado, Jonathan S. Wall
Publikováno v:
ACS Omega, Vol 2, Iss 2, Pp 712-720 (2017)
ACS Omega
ACS Omega
Light-chain (AL)-associated amyloidosis is a systemic disorder involving the formation and deposition of immunoglobulin AL fibrils in various bodily organs. One severe instance of AL disease is exhibited by the patient-derived variable domain (VL) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523f7e4460dccc1c05f0110aa27d54c4
https://doi.org/10.1021/acsomega.6b00494
https://doi.org/10.1021/acsomega.6b00494
Publikováno v:
Biochemistry. 56:757-766
Light chain (AL) amyloidosis is a lethal disease characterized by the deposition of the immunoglobulin light chain into amyloid fibrils, resulting in organ dysfunction and failure. Amyloid fibrils have the ability to self-propagate, recruiting solubl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82eda29dce8ce5a4bde1ec6f39038df5
https://doi.org/10.1021/acs.biochem.6b01043
https://doi.org/10.1021/acs.biochem.6b01043
Autor:
Allan B. Dietz, Yi Lin, Angela Williams, Keely R. Redhage, Christopher J. Dick, Khansaa Maar, Marina Ramirez-Alvarado, Jonathan S. Wall, Torri L. Jordan, Andre J. van Wijnen, Pinaki Misra, Luis M. Blancas-Mejia
Publikováno v:
Leukemia
Light chain (AL) amyloidosis is a progressive, degenerative disease characterized by the misfolding and amyloid deposition of immunoglobulin light chain (LC). The amyloid deposits lead to organ failure and death. Our laboratory is specifically intere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509ebfa5d209c1402c5c9597ac0c01f3
https://europepmc.org/articles/PMC7196017/
https://europepmc.org/articles/PMC7196017/