Lack of Clinical Relevance of Bilastine-Food Interaction in Healthy Volunteers: A Wheal and Flare Study

Autor: Jimena Coimbra, Montserrat Puntes, Ignasi Gich, Joan Martínez, Pol Molina, Rosa Antonijoan, Cristina Campo, Luis Labeaga

Publikováno v: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Introduction: The aim of this study was to compare the pharmacodynamic activity of bilastine administered under fasting and fed conditions in healthy volunteers. Methods: In this randomized, open-label, two-period, crossover study involving 24 health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f9612b436aef31fb66271eb0f1f40e
https://doi.org/10.1159/000524856

Bioequivalence Evaluation of Three Pediatric Oral Formulations of Bilastine in Healthy Subjects: Results from a Randomized, Open Label, Crossover Study

Autor: Aintzane García-Bea, José Ramón Azanza, Cristina Campo, Luis Labeaga, Belén Sádaba, Román Valiente

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 45:265-272

Bilastine is a non-sedating H1 antihistamine indicated for the treatment of allergic rhinoconjunctivitis and urticaria. The aim of this trial was to assess the bioequivalence of three novel pediatric oral formulations of bilastine. An open label, ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d777e5d88939b2cd46a3002730e247
https://doi.org/10.1007/s13318-019-00596-2

The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor

Autor: Rob Leurs, Luis Labeaga, Reggie Bosma, Jelle van den Bor, Henry F. Vischer

Publikováno v: Bosma, R, van den Bor, J, Vischer, H F, Labeaga, L & Leurs, R 2018, ' The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H 1 receptor ', European Journal of Pharmacology, vol. 838, pp. 107-111 . https://doi.org/10.1016/j.ejphar.2018.09.011
European Journal of Pharmacology, 838, 107-111. Elsevier

Drug-target binding kinetics has recently attracted considerable interest in view of the potential predictive power for in vivo drug efficacy. The recently introduced antihistamine bilastine has a long duration of in vivo drug action, which outlasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b2804d5f41b263a38e2b63d835479d
https://hdl.handle.net/1871.1/f4ba4659-e14c-4643-a1ec-7a353a0ecafd

Open-label safety assessment of bilastine in elderly patients with allergic rhinoconjunctivitis and/or urticaria

Autor: Ander Sologuren, Manuel Ruiz-Miján, Sonia Fernández, Luis Labeaga, Rosa Viñas, María Del Mar Forés, Susana E Riesgo, María Rosa Senán, Esther Cordón

Publikováno v: Allergy and asthma proceedings. 39(4)

Background Bilastine is an H1-antihistamine approved for symptomatic treatment of patients with allergic rhinoconjunctivitis or urticaria. The safety profile of bilastine in clinical trials of allergic rhinoconjunctivitis or urticaria, assessed by ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a91d060ba2210aa2e71b04aff6c4b50
https://pubmed.ncbi.nlm.nih.gov/29559031

Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers

Autor: Román Valiente, Jimena Coimbra, Consuelo García-Gea, Cristina Campo, Luis Labeaga, Ignasi Gich, Montserrat Puntes, Rosa M. Antonijoan

Publikováno v: CURRENT MEDICAL RESEARCH AND OPINION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Objective: To compare the peripheral antihistaminic activity of bilastine, rupatadine and desloratadine in inhibiting the histamine-induced wheal and flare (W&F) response. Research design and methods: Twenty-four healthy volunteers aged 18-40 years p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fd138b910fc2400a2d1bb1203e5653
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6771