Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Luis J Sigal"'
Autor:
Carolina R Melo-Silva, Pedro Alves-Peixoto, Natasha Heath, Lingjuan Tang, Brian Montoya, Cory J Knudson, Colby Stotesbury, Maria Ferez, Eric Wong, Luis J Sigal
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009593 (2021)
Type I interferons (IFN-I) are antiviral cytokines that signal through the ubiquitous IFN-I receptor (IFNAR). Following footpad infection with ectromelia virus (ECTV), a mouse-specific pathogen, C57BL/6 (B6) mice survive without disease, while B6 mic
Externí odkaz:
https://doaj.org/article/836d1951198d42dd8cf75985128c6dfe
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008239 (2019)
Cells sensing infection produce Type I interferons (IFN-I) to stimulate Interferon Stimulated Genes (ISGs) that confer resistance to viruses. During lympho-hematogenous spread of the mouse pathogen ectromelia virus (ECTV), the adaptor STING and the t
Externí odkaz:
https://doaj.org/article/f0165bc53eed4c3385cb2e11b2e88c34
Autor:
Luis J Sigal
Publikováno v:
PLoS Pathogens, Vol 14, Iss 7, p e1007000 (2018)
Externí odkaz:
https://doaj.org/article/8e014e3e191548f0b83b7a180f84de0a
Autor:
Ren-Huan Xu, Daniel Rubio, Felicia Roscoe, Tracy E Krouse, Mary Ellen Truckenmiller, Christopher C Norbury, Paul N Hudson, Inger K Damon, Antonio Alcamí, Luis J Sigal
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002475 (2012)
Type 1 interferons (T1-IFNs) play a major role in antiviral defense, but when or how they protect during infections that spread through the lympho-hematogenous route is not known. Orthopoxviruses, including those that produce smallpox and mousepox, s
Externí odkaz:
https://doaj.org/article/9654e97fb13447d9ae94d808334ea8ce
Autor:
Mark T Orr, Jun Wu, Min Fang, Luis J Sigal, Pieter Spee, Thomas Egebjerg, Erik Dissen, Sigbjørn Fossum, Joseph H Phillips, Lewis L Lanier
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15184 (2010)
The CD94 transmembrane-anchored glycoprotein forms disulfide-bonded heterodimers with the NKG2A subunit to form an inhibitory receptor or with the NKG2C or NKG2E subunits to assemble a receptor complex with activating DAP12 signaling proteins. CD94 r
Externí odkaz:
https://doaj.org/article/21970eca8f9744caa5ba6d7b90ac4517
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000768 (2010)
The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of CD8(+) T cell (T(CD8+)) responses to viruses is unclear mainly because of the difficulty in separating the two processes. Hence, while CP in the absence of DP
Externí odkaz:
https://doaj.org/article/c5dd7851d53441b08aa09d7b1ceaaec1
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e30 (2008)
Ectromelia virus (ECTV) is an orthopoxvirus (OPV) that causes mousepox, the murine equivalent of human smallpox. C57BL/6 (B6) mice are naturally resistant to mousepox due to the concerted action of innate and adaptive immune responses. Previous studi
Externí odkaz:
https://doaj.org/article/a9593830f6dc4d13a12dbb179373d012
Autor:
Nguyen T. Van, Karen Zhang, Rachel M. Wigmore, Anne I. Kennedy, Carolina R. DaSilva, Jialing Huang, Manju Ambelil, Jose H. Villagomez, Gerald J. O’Connor, Randy S. Longman, Miao Cao, Adam E. Snook, Michael Platten, Gerard Kasenty, Luis J. Sigal, George C. Prendergast, Sangwon V. Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous di
Externí odkaz:
https://doaj.org/article/ec2a535921bc46a180d596010b048d5b
Autor:
Jane Qin, Ju Hyeong Jeon, Jiangsheng Xu, Laura Katherine Langston, Ramesh Marasini, Stephanie Mou, Brian Montoya, Carolina R. Melo-Silva, Hyo Jin Jeon, Tianyi Zhu, Luis J. Sigal, Renhuan Xu, Huabin Zhu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Because of the rapid mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an effective vaccine against SARS-CoV-2 variants is needed to prevent coronavirus disease 2019 (COVID-19). T cells, in addition to neutralizing antibodies
Externí odkaz:
https://doaj.org/article/ddc2c09a6186455b81257302ddc3eeb6
Autor:
Carolina R. Melo-Silva, Cory J. Knudson, Lingjuan Tang, Samita Kafle, Lauren E. Springer, Jihae Choi, Christopher M. Snyder, Yajing Wang, Sangwon V. Kim, Luis J. Sigal
Publikováno v:
Cells, Vol 12, Iss 9, p 1343 (2023)
Genetically modified (GM) mice are essential tools in biomedical research. Traditional methods for generating GM mice are expensive and require specialized personnel and equipment. The use of clustered regularly interspaced short palindromic repeats
Externí odkaz:
https://doaj.org/article/3d8808e5067948ebbb4f0702c9fb0afb