Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Luis I. Toledo"'
Autor:
Amaia Ercilla, Kumar Somyajit, Jan Benada, Sampath Amitash, G. Baldi, Vincenzo Costanzo, Gijs Zonderland, Jiri Lukas, Fena Ochs, Luis I. Toledo
Publikováno v:
Ercilla, A, Benada, J, Amitash, S, Zonderland, G, Baldi, G, Somyajit, K, Ochs, F, Costanzo, V, Lukas, J & Toledo, L 2020, ' Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication ', Cell Reports, vol. 30, no. 7, pp. 2416-2429.e7 . https://doi.org/10.1016/j.celrep.2020.01.067
Cell Reports, Vol 30, Iss 7, Pp 2416-2429.e7 (2020)
Cell Reports
Cell Reports, Vol 30, Iss 7, Pp 2416-2429.e7 (2020)
Cell Reports
Summary: It has been long assumed that normally leading strand synthesis must proceed coordinated with the lagging strand to prevent strand uncoupling and the pathological accumulation of single-stranded DNA (ssDNA) in the cell, a dogma recently chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9247e35796fcbba84149b13abbab8955
https://curis.ku.dk/ws/files/238002374/1_s2.0_S2211124720300929_main.pdf
https://curis.ku.dk/ws/files/238002374/1_s2.0_S2211124720300929_main.pdf
Publikováno v:
Molecular Cell
Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly completion of genome duplication, and its malfunction may lead to catastrophic genome disruption, including unscheduled firing of replication origins, stalling and
Autor:
Teresa Ho, Luis I. Toledo, Simon Bekker-Jensen, Markus Räschle, Saskia Hoffmann, Peter Haahr, Niels Mailand, Maxim A. X. Tollenaere, Matthias Mann
Publikováno v:
Haahr, P, Hoffmann, S, Tollenaere, M A X, Ho, T, Toledo Lazaro, L I, Mann, M, Bekker-Jensen, S, Räschle, M & Mailand, N 2016, ' Activation of the ATR kinase by the RPA-binding protein ETAA1 ', Nature Cell Biology, vol. 18, no. 11, pp. 1196–1207 . https://doi.org/10.1038/ncb3422
Nature Cell Biology
Nature Cell Biology
Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation of ATR kinase activity by TopBP1. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3f73ffd7a1ed1539bd6d73c1eab03f
https://curis.ku.dk/portal/da/publications/activation-of-the-atr-kinase-by-the-rpabinding-protein-etaa1(d61c951a-5437-4105-b402-3faa7e81fa85).html
https://curis.ku.dk/portal/da/publications/activation-of-the-atr-kinase-by-the-rpabinding-protein-etaa1(d61c951a-5437-4105-b402-3faa7e81fa85).html
Autor:
Jiri Bartek, Vyacheslav Akimov, Luis I. Toledo, Claudia Lukas, Maj-Britt Rask, Matthias Altmeyer, Thorkell Gudjonsson, Jiri Lukas, Blagoy Blagoev, Merete Grøfte
Publikováno v:
Altmeyer, M F, Toledo, L, Gudjonsson, T, Grøfte, M, Rask, M-B, Lukas, C, Akimov, V, Blagoev, B, Bartek, J & Lukas, J 2013, ' The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling ', Molecular Cell, vol. 52, no. 2, pp. 206-220 . https://doi.org/10.1016/j.molcel.2013.08.025
Although the general relevance of chromatin modifications for genotoxic stress signaling, cell-cycle checkpoint activation, and DNA repair is well established, how these modifications reach initial thresholds in order to trigger robust responses rema
Autor:
Oscar Fernandez-Capetillo, Thomas Schleker, Maria F Montaña, Andrés J. López-Contreras, Rebeca Soria, Stefano Campaner, Luana D'Artista, Matilde Murga, Luis I. Toledo, Bruno Amati, Mariano Barbacid, Elena García, Manuel Hidalgo, Carmen Guerra
Publikováno v:
Nature Structural & Molecular Biology
Oncogene-induced replicative stress activates an Atr- and Chk1-dependent response, which has been proposed to be widespread in tumors. We explored whether the presence of replicative stress could be exploited for the selective elimination of cancer c
Autor:
Sonia Martinez, Julen Oyarzabal, James R. Bischoff, Oscar Fernandez-Capetillo, Luis I. Toledo, Matilde Murga, Antonio Rodriguez, Joaquín Pastor, Rafal Zur, Rebeca Soria
Publikováno v:
Nature Structural & Molecular Biology. 18:721-727
Oncogene activation has been shown to generate replication-born DNA damage, also known as replicative stress. The primary responder to replicative stress is not Ataxia-Telangiectasia Mutated (ATM) but rather the kinase ATM and Rad3-related (ATR). One
Autor:
Rebeca Soria, Luis I. Toledo, Matilde Murga, Paula Gutierrez-Martinez, Oscar Fernandez-Capetillo
Publikováno v:
Genes & Development. 22:297-302
The ATR kinase is a key transducer of “replicative stress,” the type of genomic damage that has been postulated to be induced by oncogenes. Here we describe a cellular system in which we can unleash ATR activity at will, in the absence of any act
Autor:
Stephen J. Smerdon, Claudia Lukas, Merete Grøfte, Luis I. Toledo, Matthias Altmeyer, Jiri Lukas, Michael L. Nielsen, Dorthe Helena Larsen, Myriam Gwerder, Flurina J. Hari, Daniel Fink, Julie A. Clapperton, Stephanie Jungmichel, Katrin Gutsche, Manuel Stucki, Maj-Britt Rask
Publikováno v:
NATURE CELL BIOLOGY
Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124d849ac8a7ca1bfecbafad2bb0cd64
https://www.zora.uzh.ch/id/eprint/104827/
https://www.zora.uzh.ch/id/eprint/104827/
Autor:
Jean-Karim Hériché, Niels Mailand, Velibor Savic, Darren N. Saunders, Jirina Bartkova, Matthias Altmeyer, Luis I. Toledo, Maria Poulsen, Claudia Lukas, Christoffel Dinant, Jiri Bartek, Robert F. Shearer, Beate Neumann, Merete Grøfte, Yasuyoshi Oka, Thorkell Gudjonsson, Jiri Lukas, Simon Bekker-Jensen
Publikováno v:
Cell. 159(6):1476-1477
SummaryHistone ubiquitylation is a prominent response to DNA double-strand breaks (DSBs), but how these modifications are confined to DNA lesions is not understood. Here, we show that TRIP12 and UBR5, two HECT domain ubiquitin E3 ligases, control acc
Publikováno v:
DNA Repair
Dear Editor, The purpose of this letter is to address the activity of CGK733, a small molecule that was reported to inhibit both ATM and ATR kinase activities and block checkpoint signaling with great selectivity [1]. This manuscript was retracted [2