Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Luis Hortells"'
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 11, p 149 (2021)
The intracardiac nervous system (IcNS), sometimes referred to as the “little brain” of the heart, is involved in modulating many aspects of cardiac physiology. In recent years our fundamental understanding of autonomic control of the heart has dr
Externí odkaz:
https://doaj.org/article/5235a03be618446f84ecaeced7fba84d
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Cardiovascular calcification was originally considered a passive, degenerative process, however with the advance of cellular and molecular biology techniques it is now appreciated that ectopic calcification is an active biological process. Vascular c
Externí odkaz:
https://doaj.org/article/cea211020e43451495167ca097b8a6c9
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 6, Iss 3, p 29 (2019)
During the postnatal period in mammals, the heart undergoes significant remodeling and cardiac cells progressively lose their embryonic characteristics. At the same time, notable changes in the extracellular matrix (ECM) composition occur with a redu
Externí odkaz:
https://doaj.org/article/2a6ed912b2a445cfa7551c907851056f
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141751 (2015)
BackgroundVascular calcification (VC) is primarily studied using cultures of vascular smooth muscle cells. However, the use of very different protocols and extreme conditions can provide findings unrelated to VC. In this work we aimed to determine th
Externí odkaz:
https://doaj.org/article/231a61b54c3640fea88db9b126ec3f4b
Autor:
Rolando A. Cuevas, Luis Hortells, Claire C. Chu, Ryan Wong, Alex Crane, Camille Boufford, Cailyn Regan, William J. Moorhead, Michael J. Bashline, Aneesha Parwal, Angelina M. Parise, Aditi Gurkar, Dennis Bruemmer, John Sembrat, Ibrahim Sultan, Thomas G. Gleason, Marie Billaud, Cynthia St. Hilaire
BackgroundCalcific aortic valve disease (CAVD) is the pathological remodeling of the valve leaflets which leads to heart failure and high stroke risk. While several mechanisms are known to drive cardiovascular calcification, the initial steps orchest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9099013df050e8bad11c75355c1c25
https://doi.org/10.1101/2022.08.23.504425
https://doi.org/10.1101/2022.08.23.504425
Autor:
Luis Hortells, Jeffery D. Molkentin, Evan C Meyer, Ronald J. Vagnozzi, Emma J Agnew, Iñigo Valiente-Alandi, Allen J. York, Katherine E. Yutzey, Zachary M. Thomas, Dan J Schnell
Publikováno v:
Proc Natl Acad Sci U S A
During the postnatal period in mammals, the cardiac muscle transitions from hyperplasic to hypertrophic growth, the extracellular matrix (ECM) undergoes remodeling, and the heart loses regenerative capacity. While ECM maturation and crosstalk between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebefc89deebdb6904e9c69da011c6a2c
https://doi.org/10.1073/pnas.2009119117
https://doi.org/10.1073/pnas.2009119117
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
We have studied inorganic phosphate (Pi) handling in rat aortic vascular smooth muscle cells (VSMC) using32P-radiotracer assays. Our results have revealed a complex set of mechanisms consisting of 1) well-known PiT1/PiT2-mediated sodium-dependent Pit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0841ae72807681d29d9cb37d0cca332e
https://doi.org/10.1152/ajpheart.00433.2019
https://doi.org/10.1152/ajpheart.00433.2019
Autor:
Rolando A Cuevas, Luis Hortells, Camille Boufford, Cailyn Regan, Ryan Wong, Alexander Crane, Claire Chu, William Moorhead, Angela Lee, Michael Bashline, Aditi Gurkar, Dennis Bruemmer, mauricio rojas, Thomas G Gleason, Marie Billaud, Ibrahim Sultan, Cynthia St Hilaire
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41
Calcific aortic valve disease (CAVD) is the leading heart valve disorder in the US. It is characterized by an active accumulation of calcium nodules on the aortic valve leaflets which lead to stiffening and remodeling of the valve leaflets causing va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0496257d3db792bbd755c4bd2101991a
https://doi.org/10.1161/atvb.41.suppl_1.mp08
https://doi.org/10.1161/atvb.41.suppl_1.mp08
Publikováno v:
J Mol Cell Cardiol
Background The intracardiac nervous system (ICNS) is composed of neurons, in association with Schwann cells (SC) and endoneurial cardiac fibroblasts (ECF). Besides heart rhythm control, recent studies have implicated cardiac nerves in postnatal cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02062cad740e1bdfffd6b3726fb8656
https://pubmed.ncbi.nlm.nih.gov/33582160
https://pubmed.ncbi.nlm.nih.gov/33582160
Autor:
Cynthia St. Hilaire, Vinayak Sant, Luis Hortells, Julie A. Phillippi, Shilpa Sant, Yingfei Xue
Publikováno v:
Cellular and Molecular Bioengineering. 10:483-500
Lack of effective pharmacological treatment makes valvular calcification a significant clinical problem in patients with valvular disease and bioprosthetic/mechanical valve replacement therapies. Elevated levels of reactive oxygen species (ROS) in va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe7f6ef6cfc1ada47643f4cf8cb87b7
https://doi.org/10.1007/s12195-017-0495-6
https://doi.org/10.1007/s12195-017-0495-6