Výsledky vyhledávání - "Luis H. Alejo"

Akademický článek

Identification of a novel ER-NFĸB-driven stem-like cell population associated with relapse of ER+ breast tumors

Autor: Svetlana E. Semina, Luis H. Alejo, Shivani Chopra, Nidhi S. Kansara, Irida Kastrati, Carol A. Sartorius, Jonna Frasor

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-19 (2022)

Abstract Background Up to 40% of patients with estrogen receptor-positive (ER+) breast cancer experience relapse. This can be attributed to breast cancer stem cells (BCSCs), which are known to be involved in therapy resistance, relapse, and metastasi

Externí odkaz: https://doaj.org/article/f3161eb0e67345e59d5aa35198f1b009

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Supplementary Figures 1-6 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Autor: Jonna Frasor, Wilbert Zwart, Sabine C. Linn, Geoffrey L. Greene, Elaine T. Alarid, Marleen Kok, Hugo M. Horlings, Joshua D. Stender, Svitlana D. Brovkovych, Luis H. Alejo, Svetlana E. Semina, Stacey E. P. Joosten, Irida Kastrati

Supplemental Figure 1. Tamoxifen treatment induces expression of NFκBB-related genes. Supplementary Figure 2. Immune cell composition and numbers in the tumor microenvironment do not significantly change upon tamoxifen treatment. Supplementary Figur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0039c4867336c4e21797615e8c21b830
https://doi.org/10.1158/1541-7786.22517821

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Supplemental Table 3 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Table 3. GSEA enrichment plots

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd6e87afccf94de96a3300f77efba1c
https://doi.org/10.1158/1541-7786.22517824.v1

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Supplemental Table 2 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Table 2. DE Genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0ff584cec9677b32ba3d9d7d689165
https://doi.org/10.1158/1541-7786.22517827

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Supplemental Table 1 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Table 1. Patient characteristics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5735c9f6f1ae5b7ac1c16ac7670f86f2
https://doi.org/10.1158/1541-7786.22517830

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Supplemental Materials and Methods and Figure Legends from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Materials and Methods and Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212580fc1d86d3e57783d811a2e882eb
https://doi.org/10.1158/1541-7786.22517833

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Estrogen Receptor-Regulated Gene Signatures in Invasive Breast Cancer Cells and Aggressive Breast Tumors

Autor: Emily Smart, Svetlana E. Semina, Luis H. Alejo, Nidhi S. Kansara, Jonna Frasor

Publikováno v: Cancers; Volume 14; Issue 12; Pages: 2848

Most metastatic breast cancers arise from estrogen receptor α (ER)-positive disease, and yet the role of ER in promoting metastasis is unclear. Here, we used an ER+ breast cancer cell line that is highly invasive in an ER- and IKKβ-dependent manner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81621ef860fca22491f67b346bd72e00
https://pubmed.ncbi.nlm.nih.gov/35740514

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The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Autor: Hugo M. Horlings, Marleen Kok, Stacey E. P. Joosten, Jonna Frasor, Irida Kastrati, Svitlana D. Brovkovych, Svetlana E. Semina, Luis H. Alejo, Joshua D. Stender, Geoffrey L. Greene, Sabine C. Linn, Wilbert Zwart, Elaine T. Alarid

Publikováno v: Mol Cancer Res

The purpose of this study was to identify critical pathways promoting survival of tamoxifen-tolerant, estrogen receptor α positive (ER+) breast cancer cells, which contribute to therapy resistance and disease recurrence. Gene expression profiling an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaf8ba16250c12dad2730dfba1e34c4
https://doi.org/10.1158/1541-7786.mcr-19-1082

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Cytoplasmic ERα and NFκB Promote Cell Survival in Mouse Mammary Cancer Cell Lines

Autor: Jonna Frasor, Emily Smart, Luis H Alejo

Publikováno v: Horm Cancer

There is a desperate need in the field for mouse mammary tumors and cell lines that faithfully mimic estrogen receptor (ER) expression and activity found in human breast cancers. We found that several mouse mammary cancer cell lines express ER but fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988a1642904a8205bed7eb51d93fc639
https://europepmc.org/articles/PMC7386283/

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