Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma

Autor: Taciani de Almeida Magalhães, Gustavo Alencastro Veiga Cruzeiro, Graziella Ribeiro de Sousa, Bernhard Englinger, Luis Fernando Peinado Nagano, Mathew Ancliffe, Keteryne Rodrigues da Silva, Li Jiang, Johannes Gojo, Yulu Cherry Liu, Brooke Carline, Mani Kuchibhotla, Fabiano Pinto Saggioro, Suely Kazue Nagahashi Marie, Sueli Mieko Oba-Shinjo, José Andres Yunes, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Raelene Endersby, Mariella G Filbin, Kleiton Silva Borges, Adrian Salic, Luiz Gonzaga Tone, Elvis Terci Valera

Publikováno v: Neuro Oncol

Background Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular mechanisms that lead to chemoresistance traits of ST-RELA remain elusive. The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf8b098a53e55cba6d9234e8b6d96d6
https://doi.org/10.1093/neuonc/noac147

A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods

Autor: Régia Caroline Peixoto Lira, Luiz Gonzaga Tone, Rosane Gomes de Paula Queiroz, Elvis Terci Valera, Mirella Baroni, María Sol Brassesco, Luis Fernando Peinado Nagano, Graziella Ribeiro de Sousa, Silvia Brandelise, Fabiano Pinto Saggioro, Carlos Alberto Scrideli, Suely Kazue Nagahashi Marie, Keteryne Rodrigues da Silva, Sueli Mieko Oba-Shinjo, Taciani de Almeida Magalhaes

Publikováno v: Journal of Molecular Medicine. 99:1101-1113

Although ependymoma (EPN) molecular subgroups have been well established by integrated high-throughput platforms, low- and middle-income countries still need low-cost techniques to promptly classify these molecular subtypes. Here, we applied low-cost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08435d838a21a01694114d3166741b68
https://doi.org/10.1007/s00109-021-02074-2

HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate

Autor: Jan Jacob Schuringa, Annet Z. Brouwers-Vos, Luis Fernando Peinado Nagano, Vanessa da Silva Silveira, Mariana Tannús Ruckert

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cancer Gene Therapy, 830-833. Nature Publishing Group
ISSUE=10-11;STARTPAGE=830;ENDPAGE=833;ISSN=0929-1903;TITLE=Cancer Gene Therapy

Acute myeloid leukemia (AML) is a poor prognosis hematopoietic malignance characterized by abnormal proliferation and differentiation of hematopoietic stem cells (HSCs). Although advances in treatment have greatly improved survival rates in young pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1513327e7ebb96706a6d5dc4719267
https://doi.org/10.1038/s41417-020-0198-3

MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways

Autor: Keteryne Rodrigues da Silva, Luiz Gonzaga Tone, Luis Fernando Peinado Nagano, Pablo Ferreira das Chagas, Kleiton S Borges, Mirella Baroni, Carolina Alves Pereira Corrêa, Carlos Alberto Scrideli, Rosane G.P. Queiroz, Luciana Chain Veronez

Publikováno v: Journal of cellular biochemistryREFERENCES. 122(12)

Adrenocortical carcinoma (ACC) is a rare, but highly aggressive cancer of the adrenal cortex with a generally poor prognosis. Despite being rare, completely resected ACCs present a high risk of recurrence. Musashi-2 (MSI2) has recently been recognize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d2e20be233190f0a53e4579a658f9e
https://pubmed.ncbi.nlm.nih.gov/34581457

Novel anti-prostate cancer scaffold identified by the combination of in silico and cell-based assays targeting the PI3K-AKT-mTOR pathway

Autor: Marta E. Saidel, Andrei Leitão, Carlos A. Montanari, Karen Cristina dos Santos, Luis Fernando Peinado Nagano

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Phenotypic assays were performed in prostate cancer cell lines to describe the biological activity of PI3K-AKT-mTOR pathway inhibitors retrieved from the virtual screening initiative. These novel chemicals share in common the aminopyridine scaffold,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35bbe32fb20211519d9fab8cb5cc45b