Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Luis F. Delgadillo-Silva"'
Autor:
Pauline Chabosseau, Fiona Yong, Luis F. Delgadillo-Silva, Eun Young Lee, Shiying Li, Nidhi Gandhi, Jules Wastin, Livia Lopez Noriega, Isabelle Leclerc, Yusuf Ali, Jing W. Hughes, Robert Sladek, Aida Martinez-Sanchez, Guy A. Rutter
AimsSpatially-organised increases in cytosolic Ca2+within pancreatic beta cells in the pancreatic islet underlie the stimulation of insulin secretion by high glucose. Recent data have revealed the existence of subpopulations of beta cells including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9756a07065abc332431493923c8653a
https://doi.org/10.1101/2022.08.26.505442
https://doi.org/10.1101/2022.08.26.505442
Publikováno v:
Current Opinion in Physiology. 14:27-34
One of the earliest studies on human pancreas regeneration dates from the beginning of the 1900s when the American pathologist Russel Cecil noted signs of attempted islet regeneration in samples from organ donors with diabetes. A century later, the q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053ba9aea9271c7e8f7b409ae08af51e
https://doi.org/10.1016/j.cophys.2019.11.009
https://doi.org/10.1016/j.cophys.2019.11.009
Autor:
Pauline Chabosseau, Fiona Yong, Luis F. Delgadillo-Silva, Eun Young Lee, Rana Melhem, Shiying Li, Nidhi Gandhi, Jules Wastin, Livia Lopez Noriega, Isabelle Leclerc, Yusuf Ali, Jing W. Hughes, Robert Sladek, Aida Martinez-Sanchez, Guy A. Rutter
Publikováno v:
Life Sciences. 316:121436
AIMS: Spatially-organized increases in cytosolic Ca2+ within pancreatic beta cells in the pancreatic islet underlie the stimulation of insulin secretion by high glucose. Recent data have revealed the existence of subpopulations of beta cells includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553e1879d5083e8e5a9161b9136b31ad
https://doi.org/10.1016/j.lfs.2023.121436
https://doi.org/10.1016/j.lfs.2023.121436
Autor:
Sharan Janjuha, Thomas Kurth, P. Olivares, A. Hnatiuk, Sumeet Pal Singh, Andreas Petzold, Nikolay Ninov, Susanne Reinhardt, O. Kayisoglu, M. Kamel, Jan Philipp Junker, Juliane Blasche, P. Chawla, Fabian Rost, Luis F. Delgadillo Silva, Annekathrin Kränkel, B. Spanjard, Sema Elif Eski
Publikováno v:
Development 149:dev199853 (2022)
Development
Development
Regeneration-competent species possess the ability to reverse the progression of severe diseases by restoring the function of the damaged tissue. However, the cellular dynamics underlying this capability remain unexplored. Here, we use single-cell tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652a6fdae6dff565de74c79c667f33ba
https://pubmed.ncbi.nlm.nih.gov/35088828
https://pubmed.ncbi.nlm.nih.gov/35088828
Autor:
Martin Werdermann, Charlotte Steenblock, Maria F. Rubin de Celis, Ilona Berger, Alice Santambrogio, Mirko Peitzsch, Cynthia L. Andoniadou, Verena Pawolski, Luis F. Delgadillo Silva, Ana Brennand, Andrew V. Schally, Stefan R. Bornstein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Steenblock, C, Rubin de Celis, M F, Delgadillo Silva, L F, Pawolski, V, Brennand, A, Werdermann, M, Berger, I, Santambrogio, A, Peitzsch, M, Andoniadou, C, Schally, A V & Bornstein, S 2018, ' Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. 12997-13002 . https://doi.org/10.1073/pnas.1814072115
Steenblock, C, Rubin de Celis, M F, Delgadillo Silva, L F, Pawolski, V, Brennand, A, Werdermann, M, Berger, I, Santambrogio, A, Peitzsch, M, Andoniadou, C, Schally, A V & Bornstein, S 2018, ' Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. 12997-13002 . https://doi.org/10.1073/pnas.1814072115
Significance Humans are constantly confronted with multiple stressors, to which the bodily response and adaptation are essential. The adrenal gland plays a major role in the response to physiological challenges. Maintenance of the adrenal is partly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363388427e7f2645fa9431ec1a933dbe
https://doi.org/10.1530/ey.16.8.2
https://doi.org/10.1530/ey.16.8.2
Autor:
Nadeem Akhtar, Whei-Chang Kim, Kinga Suba, Isabelle Leclerc, Walter Distaso, Guy A. Rutter, Neda Mousavy Gharavy, Victoria Salem, Eleni Georgiadou, David J. Hodson, Linford J.B. Briant, Nikolay Ninov, Aldara Martin Alonso, Vasiliki Kalogianni, Luis F. Delgadillo Silva
Publikováno v:
Diabetes. 68
Aim: In-vitro studies reveal a subpopulation of β cells which co-ordinate insulin release from pancreatic islets. This connectivity has not been established in 3 dimensions across the islet or in the living animal. We investigated this in the living
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073987338b2d2b03d714b79467729624
https://doi.org/10.2337/db19-42-or
https://doi.org/10.2337/db19-42-or
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 21; Issue 19; Pages: 7277
International Journal of Molecular Sciences, Vol 21, Iss 7277, p 7277 (2020)
International Journal of Molecular Sciences 21(2020)19, 7277
International Journal of Molecular Sciences; Volume 21; Issue 19; Pages: 7277
International Journal of Molecular Sciences, Vol 21, Iss 7277, p 7277 (2020)
International Journal of Molecular Sciences 21(2020)19, 7277
The intermediate filament synemin has been previously identified as novel regulator of cancer cell therapy resistance and DNA double strand break (DSB) repair. c-Abl tyrosine kinase is involved in both of these processes. Using PamGene technology, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d64f8ed39b98fa60990d5530f4e93e
https://doi.org/10.3390/ijms21197277
https://doi.org/10.3390/ijms21197277
Autor:
Stephen Rothery, David J. Hodson, Eleni Georgiadou, Piero Marchetti, Sumeet Pal Singh, S Neda Mousavy Gharavy, Kinga Suba, Victoria Salem, Walter Distaso, Timothy J. Pullen, Nikolay Ninov, Aldara Martin-Alonso, Isabelle Leclerc, David C. A. Gaboriau, Gaelle Carrat, Linford J.B. Briant, Luis F. Delgadillo Silva, Nadeem Akhtar, Theodoros Stylianides, A. M. James Shapiro, Guy A. Rutter
Publikováno v:
Nature Metabolism
Salem, V, Silva, L D, Suba, K, Georgiadou, E, Neda Mousavy Gharavy, S, Akhtar, N, Martin-alonso, A, Gaboriau, D C A, Rothery, S M, Stylianides, T, Carrat, G, Pullen, T J, Singh, S P, Hodson, D J, Leclerc, I, Shapiro, A M J, Marchetti, P, Briant, L J B, Distaso, W, Ninov, N & Rutter, G A 2019, ' Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo ', Nature Metabolism, vol. 1, no. 6, pp. 615-629 . https://doi.org/10.1038/s42255-019-0075-2
Nature Metabolism, 1 (6
Salem, V, Silva, L D, Suba, K, Georgiadou, E, Neda Mousavy Gharavy, S, Akhtar, N, Martin-alonso, A, Gaboriau, D C A, Rothery, S M, Stylianides, T, Carrat, G, Pullen, T J, Singh, S P, Hodson, D J, Leclerc, I, Shapiro, A M J, Marchetti, P, Briant, L J B, Distaso, W, Ninov, N & Rutter, G A 2019, ' Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo ', Nature Metabolism, vol. 1, no. 6, pp. 615-629 . https://doi.org/10.1038/s42255-019-0075-2
Nature Metabolism, 1 (6
Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and during continuous perfusion with blood, is unclear. In the present study, we used the recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a714ff573dd5ea50b9f5ae15629f318
Autor:
Cynthia L. Andoniadou, Mariko Sue, Stefan R. Bornstein, Maria F. Rubin de Celis, Charlotte Steenblock, Graeme Eisenhofer, Andreas Androutsellis-Theotokis, Luis F. Delgadillo Silva
Publikováno v:
Steenblock, C, Rubin de Celis, M F, Androutsellis-Theotokis, A, Sue, M, Delgadillo Silva, L F, Eisenhofer, G, Andoniadou, C L & Bornstein, S R 2016, ' Adrenal cortical and chromaffin stem cells : Is there a common progeny related to stress adaptation? ', Molecular and Cellular Endocrinology . https://doi.org/10.1016/j.mce.2016.09.011
The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b45326007ca0f7cb370f800a538949b
https://kclpure.kcl.ac.uk/en/publications/00187be5-daee-4b6e-b0e8-31a3d57a75c4
https://kclpure.kcl.ac.uk/en/publications/00187be5-daee-4b6e-b0e8-31a3d57a75c4