Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Luis F Menezes"'
Autor:
Cheng-Chao Lin, Luis F Menezes, Jiahe Qiu, Elisabeth Pearson, Fang Zhou, Yu Ishimoto, D Eric Anderson, Gregory G Germino
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0289778 (2023)
PKD1 is the most commonly mutated gene causing autosomal dominant polycystic kidney disease (ADPKD). It encodes Polycystin-1 (PC1), a putative membrane protein that undergoes a set of incompletely characterized post-transcriptional cleavage steps and
Externí odkaz:
https://doaj.org/article/59fade14ac6f4f1b8186a043aa464ac1
Publikováno v:
Advances in Kidney Disease and Health. 30:209-219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d71ac8e38b86a9abcd797c7819609b
https://doi.org/10.1053/j.akdh.2023.03.001
https://doi.org/10.1053/j.akdh.2023.03.001
Autor:
Jun-ya Kaimori, Cheng-Chao Lin, Patricia Outeda, Miguel A. Garcia-Gonzalez, Luis F. Menezes, Erum A. Hartung, Ao Li, Guanqing Wu, Hideaki Fujita, Yasunori Sato, Yasuni Nakanuma, Satoko Yamamoto, Naotsugu Ichimaru, Shiro Takahara, Yoshitaka Isaka, Terry Watnick, Luiz F. Onuchic, Lisa M. Guay-Woodford, Gregory G. Germino
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Autosomal recessive polycystic kidney disease (ARPKD) is an important childhood nephropathy, occurring 1 in 20,000 live births. The major clinical phenotypes are expressed in the kidney with dilatation of the collecting ducts, systemic hyper
Externí odkaz:
https://doaj.org/article/89f3879b5d154e2796418eb76debe918
Publikováno v:
EBioMedicine, Vol 5, Iss C, Pp 183-192 (2016)
Background: The major gene mutated in autosomal dominant polycystic kidney disease was first identified over 20 years ago, yet its function remains poorly understood. We have used a systems-based approach to examine the effects of acquired loss of Pk
Externí odkaz:
https://doaj.org/article/73cb8e35b11a4e1484a1bdb114d40861
Publikováno v:
Iheringia: Série Zoologia, Vol 105, Iss 3, Pp 271-275 (2015)
RESUMO Foram realizadas dez coletas em 2013 na RPPN Fazenda Bom Retiro, sendo cinco em uma área florestada, localizada no interior da mata e outras cinco em área aberta, distante cerca de 600 m uma da outra. O mesmo esforço de coleta foi empregado
Externí odkaz:
https://doaj.org/article/6d3cc770ae3f40e88050033d488a87f1
Autor:
Luis F. Menezes, Gregory G. Germino, H. M. Garraffo, Fang Zhou, Hongyi Cai, Peter Walter, Takeshi Terabayashi
Publikováno v:
Kidney360
Background: Multiple studies of tissue and cell samples from patients and pre-clinical models of autosomal dominant polycystic kidney disease report abnormal mitochondrial function and morphology and suggest metabolic reprogramming is an intrinsic fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c8bbd484236c63ee3b95ebe3c75a82
https://doi.org/10.34067/kid.0000962021
https://doi.org/10.34067/kid.0000962021
Autor:
Cheng-Chao Lin, Luis F. Menezes, Elisabeth Pearson, Fang Zhou, Yu Ishimoto, D. Eric Anderson, Gregory G. Germino
The localization and function of Polycystin-1, the protein encoded by the gene most commonly mutated in autosomal dominant polycystic kidney disease, remains controversial. We have recently reported that its C-terminus is cleaved and traffics to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95513640ff7438c169e445a1a61223e5
https://doi.org/10.1101/2022.04.08.487705
https://doi.org/10.1101/2022.04.08.487705
Autor:
Gregory G. Germino, Hongyi Cai, Fang Zhou, Luis F. Menezes, H. M. Garraffo, Takeshi Terabayashi, Peter Walter
BackgroundMultiple studies of tissue and cell samples from patients and pre-clinical models of autosomal dominant polycystic kidney disease report abnormal mitochondrial function and morphology and suggest metabolic reprogramming is an intrinsic feat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f396e09cef5596955864bbad8d31dd9f
https://doi.org/10.1101/2021.02.08.430145
https://doi.org/10.1101/2021.02.08.430145
Publikováno v:
Cell Signal
Systems-based, agnostic approaches focusing on transcriptomics data have been employed to understand the pathogenesis of polycystic kidney diseases (PKD). While multiple signaling pathways, including Wnt, mTOR and G-protein-coupled receptors, have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65551fa30675fcf19d2c4258ff2c4839
https://europepmc.org/articles/PMC9447370/
https://europepmc.org/articles/PMC9447370/
Autor:
Luis F Menezes, Fang Zhou, Andrew D Patterson, Klaus B Piontek, Kristopher W Krausz, Frank J Gonzalez, Gregory G Germino
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003053 (2012)
Autosomal Dominant Polycystic Kidney Disease (ADPKD; MIM ID's 173900, 601313, 613095) leads to end-stage kidney disease, caused by mutations in PKD1 or PKD2. Inactivation of Pkd1 before or after P13 in mice results in distinct early- or late-onset di
Externí odkaz:
https://doaj.org/article/4fd71d24c9564f1285c0677e7c0e1d2d