Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Luis Estévez-Salmerón"'
Autor:
Yang Shen, Luis Estévez-Salmerón, Ella F. Jones, Christopher R. Drake, Thea D. Tlsty, Philippe Gascard
Publikováno v:
Organic & biomolecular chemistry, vol 13, iss 45
Drake, CR; Estévez-Salmerón, L; Gascard, P; Shen, Y; Tlsty, TD; & Jones, EF. (2015). Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. Organic and Biomolecular Chemistry, 13(45), 11078-11086. doi: 10.1039/c5ob01805f. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4gv2v5jm
Drake, CR; Estévez-Salmerón, L; Gascard, P; Shen, Y; Tlsty, TD; & Jones, EF. (2015). Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. Organic and Biomolecular Chemistry, 13(45), 11078-11086. doi: 10.1039/c5ob01805f. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4gv2v5jm
© 2015 The Royal Society of Chemistry. Cyclooxygenases (COXs) are enzymes that play a vital role in the inflammatory cascade through the generation of prostaglandins. Their over-expression has been implicated in numerous diseases. In particular, ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4041a6c1c7cacaa6669f1bf3f17850d8
https://escholarship.org/uc/item/4gv2v5jm
https://escholarship.org/uc/item/4gv2v5jm
Autor:
Amy Wu, Thea D. Tlsty, James C. Sturm, Luis Estévez-Salmerón, Kevin Loutherback, Robert H. Austin, Guillaume Lambert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 40
Wu, A; Loutherback, K; Lambert, G; Estéèez-Salmerón, L; Tlsty, TD; Austin, RH; et al.(2013). Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proceedings of the National Academy of Sciences of the United States of America, 110(40), 16103-16108. doi: 10.1073/pnas.1314385110. UCSF: Retrieved from: http://www.escholarship.org/uc/item/238287jw
Wu, A; Loutherback, K; Lambert, G; Estéèez-Salmerón, L; Tlsty, TD; Austin, RH; et al.(2013). Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proceedings of the National Academy of Sciences of the United States of America, 110(40), 16103-16108. doi: 10.1073/pnas.1314385110. UCSF: Retrieved from: http://www.escholarship.org/uc/item/238287jw
The emergence of resistance to chemotherapy by cancer cells, when combined with metastasis, is the primary driver of mortality in cancer and has proven to be refractory to many efforts. Theory and computer modeling suggest that the rate of emergence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4412c6f5df548f7b194520dba41f26a
https://escholarship.org/uc/item/238287jw
https://escholarship.org/uc/item/238287jw
Autor:
Deirdre R. Meldrum, Hariharan Subramanian, David B. Agus, Yiider Tseng, Mark C. Lloyd, Claudia Fischbach, Kevin G. Philips, Thea D. Tlsty, Biana Godin, Jan Liphardt, Guillaume Lambert, Jonathan D. Licht, Matthew R. Dallas, Yue Geng, Jack R. Staunton, Kevin S. Kung, Jasmine Foo, Chira Chen-Tanyolac, Roger H. Johnson, Patti Senechal, Kelly Bethel, Kuldeepsinh Rana, Robert A. Gatenby, Veronica Estrella, Valerie M. Weaver, Scott S. Verbridge, Richard Bonneau, Eric C. Holland, Matthew J. Paszek, Cynthia A. Reinhart-King, Joseph E. Aslan, Wei Chiang Chen, Michael R. King, Alex Greenfield, Ahyoung Joo, Mauro Ferrari, Philippe Gascard, Vivek Nandakumar, Vadim Backman, Franziska Michor, Tyler Jacks, Sharon Gerecht, John F. Marko, Courtney Hemphill, S.P. Ashili, Laimonas Kelbauskas, Casey M. Kraning-Rush, Yolanda Stypula, Stephanie I. Fraley, Brian J. Kwee, Wadih Arap, Thomas V. O'Halloran, Abigail Hielscher, Luis Estévez-Salmerón, Jonathan E. Katz, Steven A. Curley, Arig Ibrahim-Hashim, Robert J. Gillies, Shannon M. Mumenthaler, Christine Will, Peter Kuhn, Srimeenakshi Srinivasan, Dhwanil Damania, Garth W. Tormoen, Parag Mallick, Robert H. Austin, Christian Frantz, Jenny C. Wan, Anna Lyubimova, Michael L. Shuler, Konstantinos Konstantopoulos, Nathan C. Choi, Jonathan W. Wojtkowiak, Carl Kesselman, Paolo Decuzzi, Paul Davies, Laura E. Dickinson, Gregg L. Semenza, Renata Pasqualini, Liyu Liu, Pei Hsun Wu, Barbara L. Hempstead, David Liao, W. Daniel Hillis, Owen J. T. McCarty, Robert Ros, Jenolyn F. Alexander, Alexander Fuhrmann, Jonathan Widom, Steve Oh, William M. Grady, Johnathon N. Lakins, Denis Wirtz, Alexander van Oudenaarden, Christopher S. Poultney
Publikováno v:
Scientific Reports
To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences–Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102c02fe957a17f01ad615604ee20289
http://europepmc.org/articles/PMC3636513
http://europepmc.org/articles/PMC3636513
Autor:
Beverly M. Emerson, David Liao, Luis Estévez-Salmerón, Robert H. Austin, Guillaume Lambert, Steve Oh, Thea D. Tlsty
Publikováno v:
Nature reviews. Cancer, vol 11, iss 5
Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9e34b28634e26570c69127eafb26c9
https://europepmc.org/articles/PMC3488437/
https://europepmc.org/articles/PMC3488437/
Publikováno v:
Physical biology, vol 9, iss 6
Liao, D; Estévez-Salmerón, L; & Tlsty, TD. (2012). Generalized principles of stochasticity can be used to control dynamic heterogeneity. Physical Biology, 9(6). doi: 10.1088/1478-3975/9/6/065006. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1qf2g8t3
Liao, D; Estévez-Salmerón, L; & Tlsty, TD. (2012). Generalized principles of stochasticity can be used to control dynamic heterogeneity. Physical Biology, 9(6). doi: 10.1088/1478-3975/9/6/065006. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1qf2g8t3
It is increasingly appreciated that phenotypic stochasticity plays fundamental roles in biological systems at the cellular level and that a variety of mechanisms generates phenotypic interconversion over a broad range of time scales. The ensuing dyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9436ddc62c13c48a22b04b615d590a86
https://doi.org/10.1088/1478-3975/9/6/065006
https://doi.org/10.1088/1478-3975/9/6/065006
Publikováno v:
Liao, D; Estévez-Salmerón, L; & Tlsty, TD. (2012). Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Physical Biology, 9(6). doi: 10.1088/1478-3975/9/6/065005. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5qh11178
Physical biology, vol 9, iss 6
Physical biology, vol 9, iss 6
Complex biological systems often display a randomness paralleled in processes studied in fundamental physics. This simple stochasticity emerges owing to the complexity of the system and underlies a fundamental aspect of biology called phenotypic stoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b55f9fba67d18a7489860d8eef2598
https://doi.org/10.1088/1478-3975/9/6/065005
https://doi.org/10.1088/1478-3975/9/6/065005