Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Luis Enjuanes"'
Autor:
Jose M. Honrubia, Jose R. Valverde, Diego Muñoz-Santos, Jorge Ripoll-Gómez, Nuria de la Blanca, Jorge Izquierdo, Marta Villarejo-Torres, Ana Marchena-Pasero, María Rueda-Huélamo, Ivan Nombela, Mercedes Ruiz-Yuste, Sonia Zuñiga, Isabel Sola, Luis Enjuanes
Publikováno v:
Viruses, Vol 16, Iss 8, p 1214 (2024)
The interaction between SARS-CoV PDZ-binding motifs (PBMs) and cellular PDZs is responsible for virus virulence. The PBM sequence present in the 3a and envelope (E) proteins of SARS-CoV can potentially bind to over 400 cellular proteins containing PD
Externí odkaz:
https://doaj.org/article/46ba8b5748c848e3b5f47b5fef069122
Autor:
Carlos Castaño-Rodríguez, Jose M. Honrubia, Javier Gutierrez-Álvarez, Marta L. DeDiego, Jose L. Nieto-Torres, Jose M. Jimenez-Guardeño, Jose A. Regla-Nava, Raul Fernandez-Delgado, Carmina Verdia-Báguena, Maria Queralt-Martín, Grazyna Kochan, Stanley Perlman, Vicente M. Aguilella, Isabel Sola, Luis Enjuanes
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/3b59c2f9e8454afdae7dcb85b87f2ee3
Autor:
Li Wang, María Guzman, Diego Muñoz-Santos, Jose Manuel Honrubia, Jorge Ripoll-Gomez, Rafael Delgado, Isabel Sola, Luis Enjuanes, Sonia Zuñiga
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Engineering of reverse genetics systems for newly emerged viruses allows viral genome manipulation, being an essential tool for the study of virus life cycle, virus-host interactions and pathogenesis, as well as for the development of effective antiv
Externí odkaz:
https://doaj.org/article/523585cd5a3a42a6a426c819267f7999
Autor:
Sebenzile K. Myeni, Peter J. Bredenbeek, Robert C. M. Knaap, Tim J. Dalebout, Shessy Torres Morales, Igor A. Sidorov, Marissa E. Linger, Nadia Oreshkova, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Luis Enjuanes, Isabel Sola, Eric J. Snijder, Marjolein Kikkert
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
In this work, authors provide a proof-of-concept study showing that deubiquitinating enzyme inactivation in MERS-CoV leads to attenuation in mice, and protection against a lethal challenge.
Externí odkaz:
https://doaj.org/article/499cce9a22364325b1ef3db166d2a937
Autor:
Miguel Padilla-Blanco, Santiago Vega, Luis Enjuanes, Alfonso Morey, Teresa Lorenzo, Clara Marín, Carmen Ivorra, Elisa Maiques, Vicente Rubio, Consuelo Rubio-Guerri
Publikováno v:
BMC Veterinary Research, Vol 18, Iss 1, Pp 1-9 (2022)
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has infected several animal species, including dogs, presumably via human-to-animal transmission. Most infected dogs reported were asym
Externí odkaz:
https://doaj.org/article/f9f232ec353d48788adc129847a552e5
Autor:
Sabina Andreu, Cayetano von Kobbe, Pilar Delgado, Inés Ripa, María José Buzón, Meritxell Genescà, Núria Gironès, Javier del Moral-Salmoral, Gustavo A. Ramírez, Sonia Zúñiga, Luis Enjuanes, José Antonio López-Guerrero, Raquel Bello-Morales
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The emergent human coronavirus SARS-CoV-2 and its resistance to current drugs makes the need for new potent treatments for COVID-19 patients strongly necessary. Dextran sulfate (DS) polysaccharides have long demonstrated antiviral activity against di
Externí odkaz:
https://doaj.org/article/6c50246dc6634b60b6f02faec3a06d48
Autor:
Jesus Hurtado-Tamayo, Ricardo Requena-Platek, Luis Enjuanes, Melissa Bello-Perez, Isabel Sola
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Coronaviruses (CoVs) are enveloped and positive-stranded RNA viruses with a large genome (∼ 30kb). CoVs include essential genes, such as the replicase and four genes coding for structural proteins (S, M, N and E), and genes encoding accessory prote
Externí odkaz:
https://doaj.org/article/c12555dc2c4f4bf192eb99a6c12b917c
Autor:
Luis Enjuanes, Isabel Sola, Sonia Zúñiga, José M. Honrubia, Melissa Bello-Pérez, Alejandro Sanz-Bravo, Ezequiel González-Miranda, Jesús Hurtado-Tamayo, Ricardo Requena-Platek, Li Wang, Diego Muñoz-Santos, Carlos M. Sánchez, Ana Esteban, Jorge Ripoll-Gómez
Publikováno v:
Current Research in Immunology, Vol 3, Iss , Pp 151-158 (2022)
Coronaviruses (CoVs) have the largest genome among RNA viruses and store large amounts of information without genome integration as they replicate in the cell cytoplasm. The replication of the virus is a continuous process, whereas the transcription
Externí odkaz:
https://doaj.org/article/e04daf16ecae41259caffc07dcb5dc21
Autor:
Jose M. Honrubia, Javier Gutierrez-Álvarez, Alejandro Sanz-Bravo, Ezequiel González-Miranda, Diego Muñoz-Santos, Carlos Castaño-Rodriguez, Li Wang, Marta Villarejo-Torres, Jorge Ripoll-Gómez, Ana Esteban, Raul Fernandez-Delgado, Pedro José Sánchez-Cordón, Juan Carlos Oliveros, Stanley Perlman, Paul B. McCray, Isabel Sola, Luis Enjuanes
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Coronaviruses (CoVs) of genera α, β, γ, and δ encode proteins that have a PDZ-binding motif (PBM) consisting of the last four residues of the envelope (E) protein (PBM core). PBMs may bind over 400 cellular proteins containing PDZ domain
Externí odkaz:
https://doaj.org/article/748cab695f5f46f68ab0f4651f18e0e3
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
RNA metabolism in the eukaryotic cell includes the formation of ribonucleoprotein complexes (RNPs) that, depending on their protein components, have a different function. Cytoplasmic RNPs, such as stress granules (SGs) or P-bodies (PBs) are quite rel
Externí odkaz:
https://doaj.org/article/3825767ea0294c358bdc8ebee872fd3c