Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Luis Emiliano Peña-Altamira"'
Autor:
Ferdinando Palmieri, Francesca Massenzio, Marco Virgili, Miriam Capri, Alberto Danese, Carlotta Giorgi, Sabrina Petralla, Luis Emiliano Peña-Altamira, Barbara Monti, Paolo Pinton, Emanuela Profilo, Luigi Sbano, Simona N. Barile, Francesco M. Lasorsa, Mariangela Corricelli, Eleonora Poeta, Rita Ostan
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4486 (2019)
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4486 (2019)
Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2654eb8ade0eef1d8f1d4dd0ac873dd4
Autor:
Francesca Massenzio, Aixa V. Morales, Luis Emiliano Peña-Altamira, Sabrina Petralla, Barbara Monti, Maria Laura Bolognesi, Loreto Martinez Gonzalez, Elisa Uliassi, Ana Martínez, Michele Rossi, Marinella Roberti
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
50 p.-5 fig.
Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously
Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1c49e2423d5f4c16e430dbc7d165c5
https://pubmed.ncbi.nlm.nih.gov/30253086
https://pubmed.ncbi.nlm.nih.gov/30253086
Autor:
Patricia Giuliani, Francesco Caciagli, Patrizia Di Iorio, Francesca Massenzio, Mariachiara Zuccarini, Marco Virgili, Alina Beraudi, Ilaria Mengoni, Alessandro Poli, Barbara Monti, Renata Ciccarelli, Luis Emiliano Peña-Altamira, Elisabetta Polazzi
none 13 no Available online 20 October 2017 Purine nucleoside phosphorylase (PNP), a crucial enzyme in purine metabolism which converts ribonucleosides into purine bases, has mainly been found inside glial cells. Since we recently demonstrated that P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11e4d648f7abc06c87f857fa14c8c77
http://hdl.handle.net/11585/622787
http://hdl.handle.net/11585/622787
Autor:
Luis Emiliano, Peña-Altamira, Elisabetta, Polazzi, Patricia, Giuliani, Alina, Beraudi, Francesca, Massenzio, Ilaria, Mengoni, Alessandro, Poli, Mariachiara, Zuccarini, Renata, Ciccarelli, Patrizia, Di Iorio, Marco, Virgili, Barbara, Monti, Francesco, Caciagli
Publikováno v:
Neurochemistry international. 115
Purine nucleoside phosphorylase (PNP), a crucial enzyme in purine metabolism which converts ribonucleosides into purine bases, has mainly been found inside glial cells. Since we recently demonstrated that PNP is released from rat C6 glioma cells, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6314a0caeede7f3e6d4c2dd95d0e1755
https://pubmed.ncbi.nlm.nih.gov/29061383
https://pubmed.ncbi.nlm.nih.gov/29061383
Autor:
Ondřej Soukup, Marinella Roberti, Sabrina Petralla, Maria Laura Bolognesi, Jan Korábečný, Elisa Uliassi, Manuela Bartolini, Martina Hrabinova, Laura Guidotti, Kamil Kuca, Vendula Sepsova, Barbara Monti, Jakub Jeřábek, Luis Emiliano Peña-Altamira
Multi-target drug discovery is one of the most followed approaches in the active central nervous system (CNS) therapeutic area, especially in the search for new drugs against Alzheimer's disease (AD). This is because innovative multi-target-directed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63209a921fb56e681aea0efc880ed445
http://hdl.handle.net/11585/579990
http://hdl.handle.net/11585/579990
Autor:
Irene Lagunes, Inés Maya, Luis Emiliano Peña-Altamira, Barbara Monti, Daniel Alejandre-Ramos, Maria Laura Bolognesi, José M. Padrón, Jesús M. Roldán-Peña, Manuela Bartolini, José G. Fernández-Bolaños, Óscar López
We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, chalcogenide) as new dual compounds: for the treatment of Alzheimer's disease and as antiproliferative agents. Symmetrical homodim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89910650f95a43e2709b48293f4b0b40
http://hdl.handle.net/11585/612830
http://hdl.handle.net/11585/612830
Autor:
Luigi Palmieri, Alessandra Castegna, Emanuela Profilo, Luis Emiliano Peña-Altamira, Sabrina Petralla, Massimo Zeviani, Mariangela Corricelli, Vito Porcelli, Barbara Monti, Giuseppe Fiermonte, Ferdinando Palmieri, Paolo Pinton, Giulia Giannuzzi, Luigi Sbano, Alberto Danese, Marco Virgili, Carlotta Giorgi, Carlo Viscomi, Francesca Massenzio, Erika M. Palmieri, Francesco M. Lasorsa, Gennaro Agrimi
The mitochondrial aspartate-glutamate carrier isoform 1 (AGC1) catalyzes a Ca2+-stimulated export of aspartate to the cytosol in exchange for glutamate, and is a key component of the malate-aspartate shuttle which transfers NADH reducing equivalents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f794aed749df5744d0003c16609c8667
http://hdl.handle.net/11585/586826
http://hdl.handle.net/11585/586826
Publikováno v:
Current Pharmaceutical Design. 19:5085-5092
Gene expression is controlled by several epigenetic mechanisms involving post-translational modification of histones (acetylation, phosphorylation and others). These mechanisms in the brain are not only important for normal function but also for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae3ed3da9d5b14b2313c87884e0155e
https://doi.org/10.2174/13816128113199990355
https://doi.org/10.2174/13816128113199990355
Autor:
Michel P. Rathbone, Marco Virgili, Francesco Caciagli, Elisabetta Polazzi, Silvana Buccella, Barbara Monti, Mariachiara Zuccarini, Luis Emiliano Peña-Altamira, Renata Ciccarelli, Alessandro Poli, Patricia Giuliani, Patrizia Di Iorio
Publikováno v:
Journal of neurochemistry. 141(2)
Intracellular purine turnover is mainly oriented to preserving the level of triphosphate nucleotides, fundamental molecules in vital cell functions that, when released outside cells, act as receptor signals. Conversely, high levels of purine bases an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12f95b8874b1f276a88a2e4cc8cd995
https://pubmed.ncbi.nlm.nih.gov/28251649
https://pubmed.ncbi.nlm.nih.gov/28251649
Autor:
Alessandro Pesaresi, Maria Laura Bolognesi, Jan Korabecny, Marinella Roberti, Vincenza Andrisano, Manuela Bartolini, Barbara Monti, Luis Emiliano Peña-Altamira, Sarah Samez, Eugenie Nepovimova, Christian Bergamini, Kamil Kuca, Elisa Uliassi, Doriano Lamba, Gregory E. Garcia, Romana Fato
Publikováno v:
Journal of medicinal chemistry 57 (2014): 8576–8589. doi:10.1021/jm5010804
info:cnr-pdr/source/autori:Nepovímová, Eugenie; Uliassi, Elisa; Korábecný, Jan; Peña-Altamira, Luis Emiliano; Samez, Sarah; Pesaresi, Alessandro; Garcia, Gregory E.; Bartolini, Manuela; Andrisano, Vincenza; Bergamini, Christian; Fato, Romana; Lamba, Doriano; Roberti, Marinella; Kuca, Kamil; Monti, Barbara; Bolognesi, M. L./titolo:Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects/doi:10.1021%2Fjm5010804/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:8576/pagina_a:8589/intervallo_pagine:8576–8589/volume:57
info:cnr-pdr/source/autori:Nepovímová, Eugenie; Uliassi, Elisa; Korábecný, Jan; Peña-Altamira, Luis Emiliano; Samez, Sarah; Pesaresi, Alessandro; Garcia, Gregory E.; Bartolini, Manuela; Andrisano, Vincenza; Bergamini, Christian; Fato, Romana; Lamba, Doriano; Roberti, Marinella; Kuca, Kamil; Monti, Barbara; Bolognesi, M. L./titolo:Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects/doi:10.1021%2Fjm5010804/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:8576/pagina_a:8589/intervallo_pagine:8576–8589/volume:57
We report the identification of multitarget anti-Alzheimer compounds designed by combining a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed excellent acetylcholinesterase (AChE) inhibitory potencies and interesting c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9a310ccd9288b2eeb50fe56ae16810
http://hdl.handle.net/11585/384369
http://hdl.handle.net/11585/384369