The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency

Autor: Pilar González-García, María Elena Díaz-Casado, Agustín Hidalgo-Gutiérrez, Laura Jiménez-Sánchez, Mohammed Bakkali, Eliana Barriocanal-Casado, Germaine Escames, Riccardo Zenezini Chiozzi, Franziska Völlmy, Esther A. Zaal, Celia R. Berkers, Albert J.R. Heck, Luis C. López

Publikováno v: Redox Biology, Vol 55, Iss , Pp 102403- (2022)

Defects in Coenzyme Q (CoQ) metabolism have been associated with primary mitochondrial disorders, neurodegenerative diseases and metabolic conditions. The consequences of CoQ deficiency have not been fully addressed, and effective treatment remains c

Externí odkaz: https://doaj.org/article/a2808f9af5f749cfa28f555ecb1b8d8d

Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings

Autor: Pilar González-García, Eliana Barriocanal-Casado, María Elena Díaz-Casado, Sergio López-Herrador, Agustín Hidalgo-Gutiérrez, Luis C. López

Publikováno v: Antioxidants, Vol 10, Iss 11, p 1687 (2021)

Coenzyme Q (CoQ) is a vital lipophilic molecule that is endogenously synthesized in the mitochondria of each cell. The CoQ biosynthetic pathway is complex and not completely characterized, and it involves at least thirteen catalytic and regulatory pr

Externí odkaz: https://doaj.org/article/a1125c1a52ef4f1eb8439aceaba38194

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome

Autor: Marta Luna‐Sánchez, Agustín Hidalgo‐Gutiérrez, Tatjana M Hildebrandt, Julio Chaves‐Serrano, Eliana Barriocanal‐Casado, Ángela Santos‐Fandila, Miguel Romero, Ramy KA Sayed, Juan Duarte, Holger Prokisch, Markus Schuelke, Felix Distelmaier, Germaine Escames, Darío Acuña‐Castroviejo, Luis C López

Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 1, Pp 78-95 (2016)

Abstract Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone ox

Externí odkaz: https://doaj.org/article/cfc05c1d2c8d4810a7dc5eb296a00eff

OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION

Autor: N. Ablaikhanova, Luis C. López, M. K. Murzakhmetova, B A Ussipbek

Publikováno v: Series of biological and medical. 2:31-40

The process of cell damage resulting from the action of free radicals – reactive oxygen species (ROS) – is called oxidative stress. Most ROS are constantly formed in the cell – about 5 % of the oxygen consumed by tissues is converted into free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e29a119f2eedcf26ae85666d2b06268c
https://doi.org/10.32014/10.32014/2020.2519-1629.10

Exposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach

Autor: Andrea Rodríguez-Carrillo, Shereen C. D'Cruz, Vicente Mustieles, Beatriz Suárez, Fátima Smagulova, Arthur David, Francisco Peinado, Francisco Artacho-Cordón, Luis C. López, Juan P. Arrebola, Nicolás Olea, Mariana F. Fernández, Carmen Freire

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Environmental Research
Environmental Research, 2022, 211, pp.113115. ⟨10.1016/j.envres.2022.113115⟩

This research would not have been achieved without the selfless collaboration of the INMA-Granada adolescents and families who took part in the study. The authors acknowledge the European Union's Horizon 2020 research and innovation program HBM4EUfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbb67983a8e76023c14494af7959cf5