β‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9R239X mice

Autor: Agustín Hidalgo‐Gutiérrez, Eliana Barriocanal‐Casado, Mohammed Bakkali, M Elena Díaz‐Casado, Laura Sánchez‐Maldonado, Miguel Romero, Ramy K Sayed, Cornelia Prehn, Germaine Escames, Juan Duarte, Darío Acuña‐Castroviejo, Luis C López

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-18 (2018)

Abstract Coenzyme Q (CoQ) deficiency has been associated with primary defects in the CoQ biosynthetic pathway or to secondary events. In some cases, the exogenous CoQ supplementation has limited efficacy. In the Coq9R239X mouse model with fatal mitoc

Externí odkaz: https://doaj.org/article/9013018b61324fb0803832ef7595dea9

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.

Autor: Ana López, Francisco Ortiz, Carolina Doerrier, Carmen Venegas, Marisol Fernández-Ortiz, Paula Aranda, María E Díaz-Casado, Beatriz Fernández-Gil, Eliana Barriocanal-Casado, Germaine Escames, Luis C López, Darío Acuña-Castroviejo

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0183090 (2017)

MPTP-mouse model constitutes a well-known model of neuroinflammation and mitochondrial failure occurring in Parkinson's disease (PD). Although it has been extensively reported that nitric oxide (NO●) plays a key role in the pathogenesis of PD, the

Externí odkaz: https://doaj.org/article/b1b2b621e3034003ad635b07d645433a

Treatment of CoQ(10) deficient fibroblasts with ubiquinone, CoQ analogs, and vitamin C: time- and compound-dependent effects.

Autor: Luis C López, Catarina M Quinzii, Estela Area, Ali Naini, Shamima Rahman, Markus Schuelke, Leonardo Salviati, Salvatore Dimauro, Michio Hirano

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11897 (2010)

Coenzyme Q(10) (CoQ(10)) and its analogs are used therapeutically by virtue of their functions as electron carriers, antioxidant compounds, or both. However, published studies suggest that different ubiquinone analogs may produce divergent effects on

Externí odkaz: https://doaj.org/article/4401e6bf97ef486daebf78db5f9639da

OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION

Autor: N. Ablaikhanova, Luis C. López, M. K. Murzakhmetova, B A Ussipbek

Publikováno v: Series of biological and medical. 2:31-40

The process of cell damage resulting from the action of free radicals – reactive oxygen species (ROS) – is called oxidative stress. Most ROS are constantly formed in the cell – about 5 % of the oxygen consumed by tissues is converted into free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e29a119f2eedcf26ae85666d2b06268c
https://doi.org/10.32014/10.32014/2020.2519-1629.10

Exposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach

Autor: Andrea Rodríguez-Carrillo, Shereen C. D'Cruz, Vicente Mustieles, Beatriz Suárez, Fátima Smagulova, Arthur David, Francisco Peinado, Francisco Artacho-Cordón, Luis C. López, Juan P. Arrebola, Nicolás Olea, Mariana F. Fernández, Carmen Freire

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
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Environmental Research
Environmental Research, 2022, 211, pp.113115. ⟨10.1016/j.envres.2022.113115⟩

This research would not have been achieved without the selfless collaboration of the INMA-Granada adolescents and families who took part in the study. The authors acknowledge the European Union's Horizon 2020 research and innovation program HBM4EUfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbb67983a8e76023c14494af7959cf5