Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Luis Bonet"'
Autor:
Riley D. Metcalfe, Juliana A. Martinez Fiesco, Luis Bonet-Ponce, Jillian H. Kluss, Mark R. Cookson, Ping Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The human leucine-rich repeat kinases (LRRKs), LRRK1 and LRRK2 are large and unusually complex multi-domain kinases, which regulate fundamental cellular processes and have been implicated in human disease. Structures of LRRK2 have recently b
Externí odkaz:
https://doaj.org/article/7f9154c34282440f9b99657c8f3c4db7
Autor:
Ignacio Buesa, Juan G. Pérez-Pérez, Fernando Visconti, Rebeka Strah, Diego S. Intrigliolo, Luis Bonet, Kristina Gruden, Maruša Pompe-Novak, Jose M. de Paz
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/8ead3568b7f14a63806f629333ed669a
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105769- (2022)
Coding mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene, which are associated with dominantly inherited Parkinson's disease (PD), lead to an increased activity of the encoded LRRK2 protein kinase. As such, kinase inhibitors are being consid
Externí odkaz:
https://doaj.org/article/891a483109b2470bbab47166997a07a0
Autor:
Ignacio Buesa, Juan G. Pérez-Pérez, Fernando Visconti, Rebeka Strah, Diego S. Intrigliolo, Luis Bonet, Kristina Gruden, Maruša Pompe-Novak, Jose M. de Paz
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
The use of more salt stress-tolerant vine rootstocks can be a sustainable strategy for adapting traditional grapevine cultivars to future conditions. However, how the new M1 and M4 rootstocks perform against salinity compared to conventional ones, su
Externí odkaz:
https://doaj.org/article/2a1e81cda03d45c0abd345417a7e0bd5
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Kirsten Harvey, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001621 (2022)
[This corrects the article DOI: 10.1371/journal.pbio.3001480.].
Externí odkaz:
https://doaj.org/article/0cfb6188812b44e8a7612e5d6a062027
Autor:
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001480 (2021)
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro
Externí odkaz:
https://doaj.org/article/71c689db45394c029f869d5ffc9ae238
Publikováno v:
Agronomy, Vol 12, Iss 3, p 685 (2022)
Growing consumer awareness about the environmental impact of their food purchase decisions means having to create labels that better communicate sustainability aspects. The aim of this study is to explore consumers’ responses to “sustainable irri
Externí odkaz:
https://doaj.org/article/a14c1d1886374adaa8ffbdfe8617fbee
Autor:
Alexandra Beilina, Luis Bonet-Ponce, Ravindran Kumaran, Jennifer J. Kordich, Morié Ishida, Adamantios Mamais, Alice Kaganovich, Sara Saez-Atienzar, David C. Gershlick, Dorien A. Roosen, Laura Pellegrini, Vlad Malkov, Matthew J. Fell, Kirsten Harvey, Juan S. Bonifacino, Darren J. Moore, Mark R. Cookson
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protei
Externí odkaz:
https://doaj.org/article/8f3645a2b68b47bab2889e3c6b78354d
Autor:
Ramón Gisbert-Mullor, Nuria Pascual-Seva, María Amparo Martínez-Gimeno, Lidia López-Serrano, Eduardo Badal Marín, Juan Gabriel Pérez-Pérez, Luis Bonet, Yaiza Gara Padilla, Ángeles Calatayud, Bernardo Pascual, Salvador López-Galarza
Publikováno v:
Agronomy, Vol 10, Iss 10, p 1529 (2020)
In this study, hybrid pepper rootstock NIBER® is tested for its ability to overcome water stress situations under soil conditions. The impact of deficit irrigation (DI) on yield and fruit quality, irrigation water use efficiency is evaluated, and co
Externí odkaz:
https://doaj.org/article/421e0adb0fea49d7ad0c7c70bc88a5e3
Autor:
Vivian Capilla-Gonzalez, Sara Gil-Perotin, Antonio Ferragud, Luis Bonet-Ponce, Juan Jose Canales, Jose Manuel Garcia-Verdugo
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29891 (2012)
BackgroundPrevious studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in the environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed that
Externí odkaz:
https://doaj.org/article/d3976f7d46134159859faa733dc5e9ea