Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Luis Barbeito"'
Autor:
Emiliano Trias, Mariángeles Kovacs, Catalina Alamón, Lucas Tarragó, Valentina Varela, Cecilia Maciel, Benoît Delatour, Olivier Hermine, Luis Barbeito
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S507-S508 (2023)
Externí odkaz:
https://doaj.org/article/8d363bcd46124704a1ebe8a4cb63af6e
Autor:
Mariángeles Kovacs, Catalina Alamón, Cecilia Maciel, Valentina Varela, Sofía Ibarburu, Lucas Tarragó, Peter H. King, Ying Si, Yuri Kwon, Olivier Hermine, Luis Barbeito, Emiliano Trias
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Degeneration of motor neurons, glial cell reactivity, and vascular alterations in the CNS are important neuropathological features of amyotrophic lateral sclerosis (ALS). Immune cells trafficking from the blood also infiltrate the affected C
Externí odkaz:
https://doaj.org/article/0bb5a531084d4897a403f95a98d581a9
Autor:
Luis Barbeito
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-3 (2018)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disease with no cure or treatment to stop disease progression. Because ALS represents an urgent unmet medical need, a significant number of therapeutics are being tested in preclinical
Externí odkaz:
https://doaj.org/article/aef0b6d10c0c4711ab9d9a36dc061472
Autor:
Emiliano Trias, Pamela R. Beilby, Mariángeles Kovacs, Sofía Ibarburu, Valentina Varela, Romina Barreto-Núñez, Samuel C. Bradford, Joseph S. Beckman, Luis Barbeito
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation of senescent cells. Yet, the pathogenic rol
Externí odkaz:
https://doaj.org/article/24663bf2e9884539badf6024476304e9
Autor:
Jared R. Williams, Emiliano Trias, Pamela R. Beilby, Nathan I. Lopez, Edwin M. Labut, C. Samuel Bradford, Blaine R. Roberts, Erin J. McAllum, Peter J. Crouch, Timothy W. Rhoads, Cliff Pereira, Marjatta Son, Jeffrey L. Elliott, Maria Clara Franco, Alvaro G. Estévez, Luis Barbeito, Joseph S. Beckman
Publikováno v:
Neurobiology of Disease, Vol 89, Iss , Pp 1-9 (2016)
Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration. However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks. The Cop
Externí odkaz:
https://doaj.org/article/317f96cedfe543dcbf44df3fa341418c
Autor:
Mariángeles Kovacs, Emiliano Trias, Valentina Varela, Sofia Ibarburu, Joseph S. Beckman, Ivan C. Moura, Olivier Hermine, Peter H. King, Ying Si, Yuri Kwon, Luis Barbeito
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 3880 (2019)
Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of upper and lower motor neurons accompanied by proliferation of reactive microglia in affected regions. However, it is unknown whether the hematopoietic marker CD34 can identify a
Externí odkaz:
https://doaj.org/article/b0bb920a4e834b538c6647e0cf1a86d6
Autor:
Ana G. Barbeito, Laura Martinez-Palma, Marcelo R. Vargas, Mariana Pehar, Nelly Mañay, Joseph S. Beckman, Luis Barbeito, Patricia Cassina
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 3, Pp 574-580 (2010)
Exposure to environmental lead (Pb) is a mild risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive degeneration of motor neurons. However, recent evidence has paradoxically linked higher Pb levels in A
Externí odkaz:
https://doaj.org/article/7c3b75ee91c447a4b5831a240afbce3c
Autor:
Silvia Olivera, Anabel Fernandez, Alexandra Latini, Juan Carlos Rosillo, Gabriela Casanova, Moacir Wajner, Patricia Cassina, Luis Barbeito
Publikováno v:
Neurobiology of Disease, Vol 32, Iss 3, Pp 528-534 (2008)
Glutaric (GA) and 3-hydroxyglutaric (OHGA) acids accumulate in glutaric acidemia I (GAI), a neurometabolic disease characterized by acute striatal degeneration and chronic progressive cortical atrophy. To explore the hypothesis that astrocytes are in
Externí odkaz:
https://doaj.org/article/dbab6c5b50b840a6a55074a96095110a
Autor:
Ernesto Miquel, Adriana Cassina, Laura Martínez-Palma, Carmen Bolatto, Emiliano Trías, Mandi Gandelman, Rafael Radi, Luis Barbeito, Patricia Cassina
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34776 (2012)
Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1(G93A) mutation display a decreased mitochondrial respiratory capacity assoc
Externí odkaz:
https://doaj.org/article/ca5cebc1dcb3413cabdb47af014340af
Autor:
Silvia Olivera-Bravo, Anabel Fernández, María Noel Sarlabós, Juan Carlos Rosillo, Gabriela Casanova, Marcie Jiménez, Luis Barbeito
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20831 (2011)
BACKGROUND: We have investigated whether an acute metabolic damage to astrocytes during the neonatal period may critically disrupt subsequent brain development, leading to neurodevelopmental disorders. Astrocytes are vulnerable to glutaric acid (GA),
Externí odkaz:
https://doaj.org/article/4e44ed40e7744c5fa81b87c01795d858