Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Luis B Agellon"'
Autor:
Jody Groenendyk, Qian Wang, Cory Wagg, Dukgyu Lee, Alison Robinson, Amy Barr, Peter E Light, Gary D Lopaschuk, Luis B Agellon, Marek Michalak
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236457 (2020)
Transgenic mice with selective induction of calreticulin transgene expression in cardiomyocytes (CardiacCRT+) were analyzed. CardiacCRT+ cardiomyocytes showed increased contractility and Ca2+ transients. Yet, in vivo assessment of cardiac performance
Externí odkaz:
https://doaj.org/article/195bb55409494b5282efef4d681ad526
Autor:
Naomi Dicks, Rodrigo C Bohrer, Karina Gutierrez, Marek Michalak, Luis B Agellon, Vilceu Bordignon
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187717 (2017)
Early-cleaving embryos are known to have better capacity to reach the blastocyst stage and produce better quality embryos compared to late-cleaving embryos. To investigate the significance of endoplasmic reticulum (ER) stress on early embryo cleavage
Externí odkaz:
https://doaj.org/article/e87246da2d1440b4a2bc314a2f15e4b1
Autor:
Jody Groenendyk, Dukgyu Lee, Joanna Jung, Jason R B Dyck, Gary D Lopaschuk, Luis B Agellon, Marek Michalak
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159682 (2016)
Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of m
Externí odkaz:
https://doaj.org/article/b52b9334faf44f2db81ced2cd4cdded6
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
Since domestication, pigs have been used extensively in agriculture and kept as companion animals. More recently they have been used in biomedical research, given they share many physiological and anatomical similarities with humans. Recent technolog
Externí odkaz:
https://doaj.org/article/98594be6a7de49468002f27c846be834
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Endoplasmic reticulum (ER) stress has been linked to many diseases, including cancer. A large body of work has focused on the activation of the ER stress response in cancer cells to facilitate their survival and tumor growth, however, there are some
Externí odkaz:
https://doaj.org/article/a66abf5313ed4017a280d32e2cbfe630
Autor:
Vilceu Bordignon, Nayla El-Beirouthi, Bernardo G Gasperin, Marcelo S Albornoz, Mario A Martinez-Diaz, Carine Schneider, Denyse Laurin, David Zadworny, Luis B Agellon
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64613 (2013)
The objective of this study was to demonstrate that RNA interference (RNAi) and somatic cell nuclear transfer (SCNT) technologies can be used to attenuate the expression of specific genes in tissues of swine, a large animal species. Apolipoprotein E
Externí odkaz:
https://doaj.org/article/e7b7b7f188664f6c8ff569a96bf0f48e
Autor:
Myriam Pujol, Tautvydas Paskevicius, Alison Robinson, Simran Dhillon, Paul Eggleton, Alex S. Ferecskó, Nick Gutowski, Janet Holley, Miranda Smallwood, Jia Newcombe, Luis B. Agellon, Marek Michalak
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9262 (2024)
The infiltration of immune cells into the central nervous system mediates the development of autoimmune neuroinflammatory diseases. We previously showed that the loss of either Fabp5 or calnexin causes resistance to the induction of experimental auto
Externí odkaz:
https://doaj.org/article/919261b8d0a54a9a9c6e199d23e04c94
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002553 (2012)
Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain
Externí odkaz:
https://doaj.org/article/ed37442a15fd4844952aff88383d3fd5
Autor:
Dana Praslickova, Enrique C Torchia, Michael G Sugiyama, Elijah J Magrane, Brittnee L Zwicker, Lev Kolodzieyski, Luis B Agellon
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50810 (2012)
The ileal lipid binding protein (ilbp) is a cytoplasmic protein that binds bile acids with high affinity. However evidence demonstrating the role of this protein in bile acid transport and homeostasis is missing. We created a mouse strain lacking ilb
Externí odkaz:
https://doaj.org/article/a8e76d246a484f5ab6471b2854d4f9b2
Autor:
Rafael Gianella Mondadori, Marek Michalak, Werner G. Glanzner, Naomi Dicks, M. P. Macedo, Luis B. Agellon, Vilceu Bordignon, Luke Currin, Karina Gutierrez
Publikováno v:
Biol Reprod
Conditions of impaired energy and nutrient homeostasis, such as diabetes and obesity, are associated with infertility. Hyperglycemia increases endoplasmic reticulum stress as well as oxidative stress and reduces embryo development and quality. Oxidat