Limited expression of TLR9 on T cells and its functional consequences in patients with nonalcoholic fatty liver disease

Autor: Daniel Poncino, Cecilia Claudia Garcia, Nadia Soledad Alegre, Luis Colombato, Alejandra C. Cherñavsky, Javier Benavides, Luis Ariel Billordo, Beatriz Ameigeiras

Publikováno v: Clinical and Molecular Hepatology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Clinical and Molecular Hepatology, Vol 26, Iss 2, Pp 216-226 (2020)

We demonstrated a limited expression of Toll-like receptor 9 (TLR9) and interferon gamma (IFN-γ) production by T cells in patients with simple steatosis (SS). The limited expression of TLR9 on T cells was directly associated with lower liver necroin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5611e64d7ef30e93b088a487f7a2f5
http://europepmc.org/articles/PMC7160356

Regulatory and effector T-cells are differentially modulated by Dexamethasone

Autor: Julieta Pandolfi, Florencia Payaslian, Pablo M. Fernández, Leonardo Fainboim, Lourdes Arruvito, Plácida Baz, Ailén Discianni Lupi, Luis Ariel Billordo

Publikováno v: Clinical Immunology. 149:400-410

It is assumed that the ratio between effector T cells (Teff) and regulatory T cells (Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study was to investigate if Dexamethasone (Dex) affects Teff and Tregs subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3fe59d391ced45c1adf856243507d9
https://doi.org/10.1016/j.clim.2013.09.008

ATP-Induced Inflammation Drives Tissue-Resident Th17 Cells in Metabolically Unhealthy Obesity

Autor: Ariel Ferraro, Lourdes Arruvito, Leonardo Fainboim, Inés Sananez, Plácida Baz, Julieta Pandolfi, Maria C. Gancedo, Luis Ariel Billordo

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 196(8)

Obesity-induced inflammation is conducted by a metabolic pathway, which eventually causes activation of specialized immune cells and leads to an unresolved inflammatory response within the tissue. For this reason, it is critically important to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58e454a8440a1b9a93913011c80a1d2
https://pubmed.ncbi.nlm.nih.gov/26951799

Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis

Autor: Raquel Abecasis, Luis Ariel Billordo, Maria Eugenia Inzaugarat, Alejandra C. Cherñavsky, Adrián Gadano, Nazarena E. Ferreyra Solari

Publikováno v: Journal of clinical immunology. 31(6)

Nonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease associated with insulin resistance and its metabolic consequences. Leukocyte mobilization, intrahepatic activation, and an exacerbated production of reactive oxygen species (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb095ce1024fe1a4dfcf3beca26af163
https://pubmed.ncbi.nlm.nih.gov/21845516

Analysis of Suppressor and Non-Suppressor FOXP3+ T Cells in HIV-1-Infected Patients

Autor: Julieta Pandolfi, Plácida Baz, Horacio Salomón, Lourdes Arruvito, Juan Sabatté, Jorge Geffner, María Beatriz Lasala, Leonardo Fainboim, Luis Ariel Billordo

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52580 (2012)
PLoS ONE

Recently, it was shown that peripheral blood FOXP3+CD4+ T cells are composed of three phenotypic and functionally distinct subpopulations. Two of them having in vitro suppressive effects were characterized as resting Treg cells (rTregs) and activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1983e64ebbcb5f87431d5a27b6d648a
https://doi.org/10.1371/journal.pone.0052580