In-depth comparative analysis of Tritrichomonas foetus transcriptomics reveals genes linked to host-adaptation

Autor: Luis Aníbal Diambra, Nicolás Schcolnicov, Veronica M. Coceres, Andrés M. Alonso

BACKGROUND: Tritrichomonas foetus is a protozoa flagellated that reside as a parasite or commensal in organ cavities such as the gastrointestinal and reproductive tracts of their hosts. While this parasite is an important venereal pathogen in cattle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46991585646cebb5eef166d2649d2571
https://doi.org/10.21203/rs.3.rs-419937/v1

A new analogue of islet neogenesis associated protein with higher structural and plasma stability

Autor: Luis Aníbal Diambra, Soledad Lynn, Yanis Ricardo Espinosa Silva, Bai Ru, Bárbara Maiztegui, Carolina Lisi Roman, Liu Liping, Luis Emilio Flores, Andrés N. McCarthy, Juan José Gagliardino

Publikováno v: Journal of biomolecular structuredynamics. 39(3)

Islet Neogenesis Associated Protein pentadecapeptide (INGAP-PP) increases β-cell mass and function in experimental animals. A short clinical trial also yielded promising results. However, HTD4010, a new peptide derived from INGAP-PP, was developed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bb4c0015050c8c04899ea4910ca0cf
https://pubmed.ncbi.nlm.nih.gov/31948367

Synonymous variants in holoprosencephaly alter codon usage and impact the Sonic Hedgehog protein

Autor: Luis Aníbal Diambra, Valérie Dupé, Monika Ferovova, Marie de Tayrac, Erwan Watrin, Véronique David, Christèle Dubourg, Sylvie Odent, Artem Kim, Farah Diab, Jerome Le Douce

Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2020, 143 (7), pp.2027-2038. ⟨10.1093/brain/awaa152⟩
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Brain-A Journal of Neurology, 2020, 143 (7), pp.2027-2038. ⟨10.1093/brain/awaa152⟩

Synonymous single nucleotide variants (sSNVs) have been implicated in various genetic disorders through alterations of pre-mRNA splicing, mRNA structure and miRNA regulation. However, their impact on synonymous codon usage and protein translation rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2d8a571fb908f7ad242bc82532beff
https://hal.archives-ouvertes.fr/hal-02888592

Alternating regimes of motion in cell motility models

Autor: Nara Guisoni, Luis Aníbal Diambra, K. I. Mazzitello

Cellular movement is a complex dynamic process, resulting from the interaction of multiple elements at the intra and extra-cellular levels. This epiphenomenon presents a variety of behaviors, which can include normal and anomalous diffusion or collec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed35e713b303b5a215093019862d942

Editorial: Emergent Effects of Noise in Biology: From Gene Expression to Cell Motility

Autor: Moisés Santillán, Luis Aníbal Diambra

Publikováno v: Frontiers in Physics, Vol 7 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Deterministic modeling coarse-grains unitary events into population behavior, however this approach often misses the diversity of responses in cellular and molecular systems, due to long-time effects of stochastic fluctuations. The origins of stochas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182d312a95991d15286a1be639736346
https://www.frontiersin.org/article/10.3389/fphy.2019.00083/full