A highly focused antigen receptor repertoire characterizes γδ T cells that are poised to make IL-17 rapidly in naive animals

Autor: Yu-Ling eWei, Arnold eHan, Jacob eGlanville, Fengqin eFang, Luis Alejandro Zuniga, Jacob eLee, Daniel eCua, Yueh-Hsiu eChien

Publikováno v: Frontiers in Immunology, Vol 6 (2015)

Interleukin (IL)-17 plays a key role in immunity. In acute infections, a rapid IL-17 response must be induced without prior antigen exposure, and γδ T cells are the major initial IL-17 producers. In fact, some γδ T cells make IL-17 within hours a

Externí odkaz: https://doaj.org/article/5d8a48a7ee6642b688286f747cb4295b

Degradable Hydrogel for Sustained Localized Delivery of Anti-Tumor Drugs.

Autor: Lessmann T; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Jones SA; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Voigt T; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Weisbrod S; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Kracker O; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Winter S; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Zúñiga LA; Ascendis Pharma, Inc., 1200 Bridge Parkway, Redwood City, CA 94065, USA., Stark S; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Bisek N; Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany., Sprogøe K; Ascendis Pharma A/S, Tuborg Boulevard 12, 2900 Hellerup, Denmark. Electronic address: ks@ascendispharma.com.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2023 Nov; Vol. 112 (11), pp. 2843-2852. Date of Electronic Publication: 2023 Jun 04.