Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Luis A. Passarinha"'
Autor:
Pedro Cruz-Vicente, Ana M. Gonçalves, Jorge Barroca-Ferreira, Samuel M. Silvestre, Maria J. Romão, João A. Queiroz, Eugénia Gallardo, Luis A. Passarinha
Publikováno v:
Drug discovery today. 27(10)
Catechol-O-methyltransferase (COMT) is an enzyme responsible for the O-methylation of biologically active catechol-based molecules. It has been associated with several neurological disorders, especially Parkinson's disease (PD), because of its involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fcd9a47a113c303c182fd2e2bf2011
https://pubmed.ncbi.nlm.nih.gov/35907613
https://pubmed.ncbi.nlm.nih.gov/35907613
Autor:
Fátima M. Santos, Sergio Ciordia, Joana Mesquita, Carla Cruz, João Paulo Castro e Sousa, Luís A. Passarinha, Cândida T. Tomaz, Alberto Paradela
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDiabetic retinopathy (DR) and age-related macular degeneration (AMD) are leading causes of visual impairment and blindness in people aged 50 years or older in middle-income and industrialized countries. Anti-VEGF therapies have improved t
Externí odkaz:
https://doaj.org/article/b47b6b43e8b948668f7d1984c5c9043d
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 936 (2023)
Quercetin is a natural flavonoid with high anticancer activity, especially for related-HPV cancers such as cervical cancer. However, quercetin exhibits a reduced aqueous solubility and stability, resulting in a low bioavailability that limits its the
Externí odkaz:
https://doaj.org/article/3e9b67b91f0f4b579c80f543193e7748
Autor:
Carina Gameiro, Joana Gonçalves, Sofia Soares, Tiago Rosado, André R. T. S. Araujo, Luís A. Passarinha, Mário Barroso, Eugenia Gallardo
Publikováno v:
Molecules, Vol 28, Iss 5, p 2030 (2023)
Antipsychotics have narrow therapeutic windows, and their monitoring in biological fluids is therefore important; consequently, stability in those fluids must be investigated during method development and validation. This work evaluates the stability
Externí odkaz:
https://doaj.org/article/1a045d9a62ef45549a8be9df00cde0f5
Autor:
Ana Teresa Brinca, Ofélia Anjos, Maria Manuel Casteleiro Alves, Ângela Sousa, António Hélio Oliani, Luiza Breitenfeld, Luís A. Passarinha, Ana Cristina Ramalhinho, Eugenia Gallardo
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2852 (2022)
Due to its high prevalence, infertility has become a prominent public health issue, posing a significant challenge to modern reproductive medicine. Some clinical conditions that lead to female infertility include polycystic ovary syndrome (PCOS), end
Externí odkaz:
https://doaj.org/article/fa763877d6a345bab3b4ede2ae178010
Autor:
Ana Raquel Neves, Tânia Albuquerque, Rúben Faria, Ana M. Gonçalves, Cecília Santos, Eric Vivès, Prisca Boisguérin, Luís A. Passarinha, Ângela Sousa, Diana Costa
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2213 (2022)
Despite the great progress over the past few decades in both the diagnosis and treatment of a great variety of human cancers, glioblastoma remains the most lethal brain tumor. In recent years, cancer gene therapy focused on non-viral vectors which em
Externí odkaz:
https://doaj.org/article/03653188c41a439ba72af25b2b755f93
Autor:
Luana M. Rosendo, Tiago Rosado, Patrik Oliveira, Ana Y. Simão, Cláudia Margalho, Suzel Costa, Luís A. Passarinha, Mário Barroso, Eugenia Gallardo
Publikováno v:
Molecules, Vol 27, Iss 17, p 5503 (2022)
Cannabis is the most consumed illicit drug worldwide, and its legal status is a source of concern. This study proposes a rapid procedure for the simultaneous quantification of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH
Externí odkaz:
https://doaj.org/article/b105b3d3801d415cbbeef02117c5fd04
Publikováno v:
Molecules, Vol 27, Iss 10, p 3188 (2022)
New developments in instrumental approaches, for instance, hyphenated techniques, have allowed great advances in the bioanalytical field over the last half century, and there is no doubt that toxicology was one of the most improved areas [...]
Externí odkaz:
https://doaj.org/article/c6c82b01f8ab460286e5fe1ea0928bc7
Autor:
Ana Teresa Brinca, Ana Cristina Ramalhinho, Ângela Sousa, António Hélio Oliani, Luiza Breitenfeld, Luís A. Passarinha, Eugenia Gallardo
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1254 (2022)
Polycystic ovary syndrome (PCOS) represents one of the leading causes of anovulatory infertility and affects 5% to 20% of women worldwide. Until today, both the subsequent etiology and pathophysiology of PCOS remain unclear, and patients with PCOS th
Externí odkaz:
https://doaj.org/article/dbb55453c80149e8b7e94e54fd4a16d7
Publikováno v:
Data, Vol 7, Iss 5, p 64 (2022)
The human Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) family comprises STEAP1-4. Several studies have pointed out STEAP proteins as putative biomarkers, as well as therapeutic targets in several types of human cancers, particularly i
Externí odkaz:
https://doaj.org/article/928da698ace649a6b502357ff61100a3