Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Luis A. Martinez-Lemus"'
Autor:
Zahra Nourian, Kwangseok Hong, Min Li, Jorge A. Castorena-Gonzalez, Luis A. Martinez-Lemus, Philip S. Clifford, Gerald A. Meininger, Michael A. Hill
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Vascular extracellular matrix (ECM) is dominated by elastic fibers (elastin with fibrillin-rich microfibrils) and collagens. Current understanding of ECM protein development largely comes from studies of conduit vessels (e.g., aorta) wh
Externí odkaz:
https://doaj.org/article/6d8b2f396a4049b7bff826333ab77c6f
Autor:
Linfang Zhang, Xiujuan Xia, Hao Wu, Xuanyou Liu, Qiang Zhu, Meifang Wang, Hong Hao, Yuqi Cui, De-Pei Li, Shi-You Chen, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
BackgroundSubstantial sex differences exist in atherosclerosis. Excessive reactive oxygen species (ROS) formation could lead to endothelial dysfunction which is critical to atherosclerosis development and progression. Helicobacter pylori (H. pylori)
Externí odkaz:
https://doaj.org/article/22e29d190e62472b88e4d50867b430c2
Autor:
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundHelicobacter pylori (H. pylori) infection increases the risk for atherosclerosis, and ROS are critical to endothelial dysfunction and atherosclerosis. CagA is a major H. pylori virulence factor associated with atherosclerosis. The present s
Externí odkaz:
https://doaj.org/article/86fe33103dc54482bb065affa7021266
Autor:
Shumpei Fujie, Natsuki Hasegawa, Naoki Horii, Masataka Uchida, Kiyoshi Sanada, Takafumi Hamaoka, Jaume Padilla, Luis A. Martinez‐Lemus, Seiji Maeda, Motoyuki Iemitsu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 10 (2021)
Background Adropin is a peptide hormone that promotes nitric oxide (NO) production via activation of endothelial NO synthase (eNOS) in endothelial cells. Its circulating levels are reduced with aging and increased with aerobic exercise training (AT).
Externí odkaz:
https://doaj.org/article/ceda2057d1bb45d0aba8a668f164e245
Autor:
Camila Manrique-Acevedo, Jaume Padilla, Huma Naz, Makenzie L. Woodford, Thaysa Ghiarone, Annayya R. Aroor, Jack L. Hulse, Francisco J. Cabral-Amador, Vanesa Martinez-Diaz, Chetan P. Hans, Adam Whaley-Connell, Luis A. Martinez-Lemus, Guido Lastra
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Enhanced mineralocorticoid receptor (MR) signaling is critical to the development of endothelial dysfunction and arterial stiffening. However, there is a lack of knowledge about the role of MR-induced adipose tissue inflammation in the genesis of vas
Externí odkaz:
https://doaj.org/article/68eda70340d34485a839842d3f9aa89c
Autor:
Ghazaleh Behnammanesh, Zane E. Durante, Kelly J. Peyton, Luis A. Martinez-Lemus, Scott M. Brown, Shawn B. Bender, William Durante
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Recent clinical trials revealed that sodium-glucose co-transporter 2 (SGLT2) inhibitors significantly reduce cardiovascular events in type 2 diabetic patients, however, canagliflozin increased limb amputations, an effect not seen with other SGLT2 inh
Externí odkaz:
https://doaj.org/article/d90c10ed39e140e7bdd684c2192bb02a
Autor:
Luis A. Martinez-Lemus, Annayya R. Aroor, Francisco I. Ramirez-Perez, Guanghong Jia, Javad Habibi, Vincent G. DeMarco, Brady Barron, Adam Whaley-Connell, Ravi Nistala, James R. Sowers
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Obese premenopausal women lose their sex related cardiovascular disease protection and develop greater arterial stiffening than age matched men. In female mice, we have shown that consumption of a Western diet (WD), high in fat and refined sugars, is
Externí odkaz:
https://doaj.org/article/0d2ffd89d1fc4870b097bf206885df63
Autor:
Marius C. Staiculescu, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Luis A. Martinez-Lemus
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-ind
Externí odkaz:
https://doaj.org/article/e68e073a162f4a9aa3215f3330acc666
Autor:
Camila Manrique-Acevedo, Rogerio N. Soares, James A. Smith, Lauren K. Park, Katherine Burr, Francisco I. Ramirez-Perez, Neil J. McMillan, Larissa Ferreira-Santos, Neekun Sharma, T. Dylan Olver, Craig A. Emter, Elizabeth J. Parks, Jacqueline K. Limberg, Luis A. Martinez-Lemus, Jaume Padilla
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R293-R304
Vascular insulin resistance, a major characteristic of obesity and type 2 diabetes (T2D), manifests with blunting of insulin-induced vasodilation. Although there is evidence that females are more whole body insulin sensitive than males in the healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6cc608667930643d3fee84de17e81c
https://doi.org/10.1152/ajpregu.00249.2022
https://doi.org/10.1152/ajpregu.00249.2022
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1231-H1238
Insulin resistance in the vasculature is a hallmark of type 2 diabetes (T2D), and blunting of insulin-induced vasodilation is its primary consequence. Individuals with T2D exhibit a marked impairment in insulin-induced dilation in resistance arteries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fece17c595d0e2d43b61f1f724c511ab
https://doi.org/10.1152/ajpheart.00537.2022
https://doi.org/10.1152/ajpheart.00537.2022