Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Luis A. Marky"'
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Topoisomerase 1 (Top1) enzymes regulate DNA superhelicity by forming covalent cleavage complexes that undergo controlled rotation. Substitution of nucleoside analogs at the +1 position of the DNA duplex relative to the Top1 cleavage site inhibits DNA
Externí odkaz:
https://doaj.org/article/750e52c6bb934f349072ab7d61525691
Autor:
Aishwarya Prakash, Amarnath Natarajan, Luis A. Marky, Michel M. Ouellette, Gloria E. O. Borgstahl
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Replication protein A (RPA), a key player in DNA metabolism, has 6 single-stranded DNA-(ssDNA-) binding domains (DBDs) A-F. SELEX experiments with the DBDs-C, -D, and -E retrieve a 20-nt G-quadruplex forming sequence. Binding studies show that RPA-DE
Externí odkaz:
https://doaj.org/article/3854842665604748bda46ecb1e52d393
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Externí odkaz:
https://doaj.org/article/06faef78ded04a8c8e6af75faad0d3da
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Replication protein A (RPA) plays an essential role in DNA replication by binding and unfolding non-canonical single-stranded DNA (ssDNA) structures. Of the six RPA ssDNA binding domains (labeled A-F), RPA-CDE selectively binds a G-quadruplex forming
Externí odkaz:
https://doaj.org/article/f11d1b01ac1e4307abb2451240ea2ca7
Publikováno v:
Biophysical Journal. 121:4892-4899
High hydrostatic pressure can have profound effects on the stability of biomacromolecules. The magnitude and direction (stabilizing or destabilizing) of this effect is defined by the volume changes in the system, ΔV. Positive volume changes will sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66bd76b6fb2a8cbf9103cedb767ad07
https://doi.org/10.1016/j.bpj.2022.08.005
https://doi.org/10.1016/j.bpj.2022.08.005
Autor:
Suravi Pramanik, Yingling Chen, Heyu Song, Irine Khutsishvili, Luis A Marky, Sutapa Ray, Amarnath Natarajan, Pankaj K Singh, Kishor K Bhakat
Publikováno v:
Nucleic Acids Research. 50:3394-3412
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich region in KRAS promoter can fold into a four-stranded DNA secondary struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bbf12da443c169932ab3847f1e47d3
https://doi.org/10.1093/nar/gkac172
https://doi.org/10.1093/nar/gkac172
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13cc1ed6f708cc7bdff17422c455c938
https://doi.org/10.1007/978-981-16-1313-5_35-1
https://doi.org/10.1007/978-981-16-1313-5_35-1
Autor:
Luis A. Marky
Publikováno v:
Biophysical Journal. 122:210a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba3966eed7f8a895da17215364ad88d5
https://doi.org/10.1016/j.bpj.2022.11.1257
https://doi.org/10.1016/j.bpj.2022.11.1257
Increased Flexibility between Stems of Intramolecular Three-Way Junctions by the Insertion of Bulges
Autor:
Carolyn E. Carr, Luis A. Marky
Publikováno v:
Biophysical Journal. 114:2764-2774
Intramolecular junctions are a ubiquitous structure within DNA and RNA; three-way junctions in particular have high strain around the junction because of the lack of flexibility, preventing the junctions from adopting conformations that would allow f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b50491a44f6ab23f58ab96ce946d644
https://doi.org/10.1016/j.bpj.2018.05.001
https://doi.org/10.1016/j.bpj.2018.05.001
Publikováno v:
Biochimie. 146:156-165
Oligonucleotide-directed triple helix formation has been recognized as a potential tool for targeting genes with high specificity. Cystosine methylation in the 5' position is both ubiquitous and a stable regulatory modification, which could potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bcab6e4ee2c79cb623ae8e9daba3b8d
https://doi.org/10.1016/j.biochi.2017.12.008
https://doi.org/10.1016/j.biochi.2017.12.008