Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Luis A. Gomez-Sarosi"'
Autor:
Jared M. Lucas, Roger Coleman, Luis A. Gomez-Sarosi, Song Zhao, Peter S. Nelson, Ilsa Coleman, Roland M. Huber
Publikováno v:
Oncotarget
Though metastatic cancers often initially respond to genotoxic therapeutics, acquired resistance is common. In addition to cytotoxic effects on tumor cells, DNA damaging agents such as ionizing radiation and chemotherapy induce injury in benign cells
Publikováno v:
Chemico-biological interactions. 188(1)
The pro-oxidant hydrogen peroxide (H(2)O(2)) is converted to a reactive oxygen species by transition metals like iron. Since mutations in the p53 tumor suppressor gene contribute to drug resistance, we used genetically-matched human C8161 melanoma ha
Publikováno v:
Cancer biologytherapy. 8(12)
Constitutive ERK activation, superoxide dismutases (SOD) and p53 mutations are implicated in modulating tumor apoptotic response. We now investigated whether human melanoma survival in response to sodium nitroprusside (SNP) is modulated by: (a) stabl
Publikováno v:
Biochemical and biophysical research communications. 312(2)
Differentiated melanocytic cells produce melanin, through several redox reactions including tyrosinase-catalyzed DOPA oxidation to DOPA quinone. We now developed a method based on DOPA oxidase in-gel detection and Sypro Ruby fluorometric normalizatio