Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Luis A Rokeach"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121059 (2015)
Cell fate is determined by the balance of conserved molecular mechanisms regulating death (apoptosis) and survival (autophagy). Autophagy is a process by which cells recycle their organelles and macromolecules through degradation within the vacuole i
Externí odkaz:
https://doaj.org/article/b30df97c288246ceb0b854a45422b8dd
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6939 (2009)
The molecular chaperone Hsp104 is a crucial factor in the acquisition of thermotolerance in yeast. Under stress conditions, the disaggregase activity of Hsp104 facilitates the reactivation of misfolded proteins. Hsp104 is also involved in the propaga
Externí odkaz:
https://doaj.org/article/9c7d1e3b56c9447e9e9f0cdc371a5660
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6244 (2009)
Inositol is a precursor of numerous phospholipids and signalling molecules essential for the cell. Schizosaccharomyces pombe is naturally auxotroph for inositol as its genome does not have a homologue of the INO1 gene encoding inositol-1-phosphate sy
Externí odkaz:
https://doaj.org/article/75b4664345004d4a91c212233eb54698
Autor:
Antoine E Roux, Alexandre Leroux, Manal A Alaamery, Charles S Hoffman, Pascal Chartrand, Gerardo Ferbeyre, Luis A Rokeach
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000408 (2009)
Glucose is the preferred carbon and energy source in prokaryotes, unicellular eukaryotes, and metazoans. However, excess of glucose has been associated with several diseases, including diabetes and the less understood process of aging. On the contrar
Externí odkaz:
https://doaj.org/article/92c7bbee5fc7471198fb000cbff45725
Inter-species complementation of the translocon beta subunit requires only its transmembrane domain.
Autor:
Alexandre Leroux, Luis A Rokeach
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3880 (2008)
In eukaryotes, proteins enter the secretory pathway through the translocon pore of the endoplasmic reticulum. This protein translocation channel is composed of three major subunits, called Sec61alpha, beta and gamma in mammals. Unlike the other subun
Externí odkaz:
https://doaj.org/article/c49d5ef3ab6443a7ad5198c95322ad1b
Publikováno v:
Annals of the New York Academy of Sciences. 1197:19-27
We present results showing that glucose signaling has proaging effects in the yeast Schizosaccharomyces pombe. Deletion of the receptor that senses extracellular glucose (Git3) increases the life span of S.pombe, while constitutive activation of the
Publikováno v:
FEMS Yeast Research. 9:1250-1259
Yeasts have evolved numerous responsive pathways to survive in fluctuating and stressful environments. The endoplasmic reticulum (ER) is sensitive to adverse conditions, which are detected by response pathways to ensure correct protein folding. Calne
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :1-8
In the past years, simple organisms such as yeasts and worms have contributed a great deal to aging research. Studies pioneered in Saccharomyces cerevisiae were useful to elucidate a significant number of molecular mechanisms underlying cellular agin
Publikováno v:
Yeast. 24:89-103
Protein secretion is a complex process that can be modulated by folding factors in the endoplasmic reticulum (ER), such as calnexin, a highly-conserved molecular chaperone involved in quality control. In Schizosaccharomyces pombe, calnexin (Cnx1p) is
Publikováno v:
Aging Cell. 5:345-357
Budding yeast shows a progressive decline in viability after entering stationary phase, a phenomenon known as chronological aging. We show here that the fission yeast Schizosaccharomyces pombe also undergoes chronological aging and that the process i