Zobrazeno 1 - 10
of 593
pro vyhledávání: '"Luis A Pardo"'
Publikováno v:
eLife, Vol 12 (2024)
The KCNH family of potassium channels serves relevant physiological functions in both excitable and non-excitable cells, reflected in the massive consequences of mutations or pharmacological manipulation of their function. This group of channels shar
Externí odkaz:
https://doaj.org/article/2894c73d50354304953d0851cd9fd955
Autor:
María José Bruning, David Véliz, Noemí Rojas-Hernández, José Garcés-Vargas, Ignacio Garrido, María José Cid, Kurt Paschke, Luis Miguel Pardo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Marine heatwaves (MHW) pose an increasing threat and have a critical impact on meroplanktonic organisms, because their larvae are highly sensitive to environmental stress and key for species’ dispersion and population connectivity. This st
Externí odkaz:
https://doaj.org/article/1f7d2c3f0836402f86326f1addbc77ae
Autor:
Lien Moreels, Chinmay Bhat, Manuela Voráčová, Steve Peigneur, Hannah Goovaerts, Eero Mäki-Lohiluoma, Farrah Zahed, Luis A Pardo, Jari Yli-Kauhaluoma, Paula Kiuru, Jan Tytgat
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188811 (2017)
In the search for novel anticancer drugs, the potassium channel KV10.1 has emerged as an interesting cancer target. Here, we report a new group of KV10.1 inhibitors, namely the purpurealidin analogs. These alkaloids are produced by the Verongida spon
Externí odkaz:
https://doaj.org/article/e0035199f2d84432b06632e4aaa95559
Autor:
Alonso Barrantes-Freer, Mirjam Renovanz, Marcus Eich, Alina Braukmann, Bettina Sprang, Pavel Spirin, Luis A Pardo, Alf Giese, Ella L Kim
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130519 (2015)
A transmembrane protein CD133 has been implicated as a marker of stem-like glioma cells and predictor for therapeutic response in malignant brain tumours. CD133 expression is commonly evaluated by using antibodies specific for the AC133 epitope locat
Externí odkaz:
https://doaj.org/article/1f878a9de9824fcc9ee8e9bef4dc4bf2
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Although crucial for their correct function, the mechanisms controlling surface expression of ion channels are poorly understood. In the case of the voltage-gated potassium channel KV10.1,this is determinant not only for its physiological function in
Externí odkaz:
https://doaj.org/article/3e2f327aae9349dd88a74c002d28d5f3
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51825 (2012)
Overexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific
Externí odkaz:
https://doaj.org/article/24849c1e8c6b48b8985b29ccd48a82ad
Autor:
Salamanca, William1, Luis Padrón-Pardo, Óscar1, Riscanevo-Bobadilla, Carolina2 caroriscanevo@unisanitas.edu.co, Saavedra, Paulo2, Castillo, Juliana3
Publikováno v:
Revista Colombiana de Cirugía. sep/oct2024, Vol. 39 Issue 5, p799-805. 7p.
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19257 (2011)
Ectopically expressed human K(V)10.1 channels are relevant players in tumor biology. However, their function as ion channels at the plasma membrane does not totally explain their crucial role in tumors. Both in native and heterologous systems, it has
Externí odkaz:
https://doaj.org/article/356578e123ab419faa3900a9bc0df4b7
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26329 (2011)
K(V)10.1 is a mammalian brain voltage-gated potassium channel whose ectopic expression outside of the brain has been proven relevant for tumor biology. Promotion of cancer cell proliferation by K(V)10.1 depends largely on ion flow, but some oncogenic
Externí odkaz:
https://doaj.org/article/19cf82bb623d40a9973a10ddf028828c
Autor:
David Gómez-Varela, Tobias Kohl, Manuela Schmidt, María E Rubio, Hiroshi Kawabe, Ralf B Nehring, Stephan Schäfer, Walter Stühmer, Luis A Pardo
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8858 (2010)
Voltage-gated ion channels are main players involved in fast synaptic events. However, only slow intracellular mechanisms have so far been described for controlling their localization as real-time visualization of endogenous voltage-gated channels at
Externí odkaz:
https://doaj.org/article/432dd58505a54dcfb4d4a4f98e1fc28d