Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Luis Ángel Fernandez"'
Autor:
Guillermo Valenzuela Nieto, Ronald Jara, Daniel Watterson, Naphak Modhiran, Alberto A. Amarilla, Johanna Himelreichs, Alexander A. Khromykh, Constanza Salinas-Rebolledo, Teresa Pinto, Yorka Cheuquemilla, Yago Margolles, Natalia López González del Rey, Zaray Miranda-Chacon, Alexei Cuevas, Anne Berking, Camila Deride, Sebastián González-Moraga, Héctor Mancilla, Daniel Maturana, Andreas Langer, Juan Pablo Toledo, Ananda Müller, Benjamín Uberti, Paola Krall, Pamela Ehrenfeld, Javier Blesa, Pedro Chana-Cuevas, German Rehren, David Schwefel, Luis Ángel Fernandez, Alejandro Rojas-Fernandez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Despite unprecedented global efforts to rapidly develop SARS-CoV-2 treatments, in order to reduce the burden placed on health systems, the situation remains critical. Effective diagnosis, treatment, and prophylactic measures are urgently req
Externí odkaz:
https://doaj.org/article/ee67da82c4154da782d61078ae559f70
Autor:
Alejandro Prieto, Luïsa Miró, Yago Margolles, Manuel Bernabeu, David Salguero, Susana Merino, Joan Tomas, Juan Alberto Corbera, Anna Perez-Bosque, Mario Huttener, Luis Ángel Fernández, Antonio Juarez
Publikováno v:
eLife, Vol 13 (2024)
Antimicrobial resistance (AMR) poses a significant threat to human health. Although vaccines have been developed to combat AMR, it has proven challenging to associate specific vaccine antigens with AMR. Bacterial plasmids play a crucial role in the t
Externí odkaz:
https://doaj.org/article/f7646182647d497e95517f001fbd4d79
Autor:
Alejandro Asensio‐Calavia, Álvaro Ceballos‐Munuera, Almudena Méndez‐Pérez, Beatriz Álvarez, Luis Ángel Fernández
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Biosafety of engineered bacteria as living therapeutics requires a tight regulation to control the specific delivery of protein effectors, maintaining minimum leakiness in the uninduced (OFF) state and efficient expression in the induced (ON
Externí odkaz:
https://doaj.org/article/91634fbd055a449586e79b3d35d32543
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Large gene libraries are frequently created in Escherichia coli plasmids, which can induce cell toxicity and expression instability due to the high gene dosage. To address these limitations, gene libraries can be integrated in a single copy
Externí odkaz:
https://doaj.org/article/db02c5da620348f399249a76b680b9ac
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 9, Pp 2309-2323 (2022)
Summary The ability of T7 RNA polymerase (RNAPT7) fusions to cytosine deaminases (CdA) for entering C➔T changes in any DNA segment downstream of a T7 promoter was exploited for hyperdiversification of defined genomic portions of Pseudomonas putida
Externí odkaz:
https://doaj.org/article/6615936fafc14f53aa2764757d8e8013
Publikováno v:
Ecología Política, 1995 Jan 01(8), 7-12.
Externí odkaz:
https://www.jstor.org/stable/20742798
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-12 (2022)
Abstract Background Bacterial type III secretion systems (T3SSs) assemble a multiprotein complex termed the injectisome, which acts as a molecular syringe for translocation of specific effector proteins into the cytoplasm of host cells. The use of in
Externí odkaz:
https://doaj.org/article/cd00e94d69614c2ea65558afea0e5aaa
Autor:
Elena M. Seco, Luis Ángel Fernández
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 5, Pp 1374-1391 (2022)
Summary The probiotic strain Escherichia coli Nissle 1917 (EcN) is a common bacterial chassis in synthetic biology developments for therapeutic applications given its long track record of safe administration in humans. Chromosomal integration of the
Externí odkaz:
https://doaj.org/article/6345925d4fff4ffd9c9e177be1544087
Autor:
Yamal Al-ramahi, Akos Nyerges, Yago Margolles, Lidia Cerdán, Gyorgyi Ferenc, Csaba Pál, Luis Ángel Fernández, Víctor de Lorenzo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Yamal Al-ramahi et al. describe an accelerated laboratory evolution method that applies ssDNA recombineering and bacterial surface display to engineer nanobody epitope recognition. As a proof-of-concept, they evolved TD4 recognition to bind the trans
Externí odkaz:
https://doaj.org/article/7cfb63c37a134a1381dcf213cbee4ff5
Autor:
Francisca Mulero, Marta Oteo, Guillermo Garaulet, Natalia Magro, Lluvia Rebollo, Guillermo Medrano, Clara Santiveri, Eduardo Romero, Ricela E. Sellek, Yago Margolles, Ramón Campos-Olivas, Alicia G. Arroyo, Luis Angel Fernández, Miguel Angel Morcillo, Jorge L. Martínez-Torrecuadrada
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Triple-negative breast cancer (TNBC) is characterized by aggressiveness and high rates of metastasis. The identification of relevant biomarkers is crucial to improve outcomes for TNBC patients. Membrane type 1-matrix metalloproteinase (MT1-MMP) could
Externí odkaz:
https://doaj.org/article/9f56d62e2e19476389ae4a1143daab5c