Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Luis, Quintino"'
Autor:
Martino Avallone, Joaquín Pardo, Tadiwos F. Mergiya, Jana Rájová, Atte Räsänen, Marcus Davidsson, Malin Åkerblom, Luis Quintino, Darshan Kumar, Clive R. Bramham, Tomas Björklund
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into ca
Externí odkaz:
https://doaj.org/article/d8913b1da5ea409b971a24396f2ff4f3
Autor:
Isak Martinsson, Luis Quintino, Megg G. Garcia, Sabine C. Konings, Laura Torres-Garcia, Alexander Svanbergsson, Oliver Stange, Rebecca England, Tomas Deierborg, Jia-Yi Li, Cecilia Lundberg, Gunnar K. Gouras
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and cellular mechanism(s) by which Aβ and/or its precursor protein, the amyloi
Externí odkaz:
https://doaj.org/article/ff57882822e84937998f1dfb99ae5e93
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Gene therapy approaches using viral vectors for the overexpression of target genes have been for several years the focus of gene therapy research against neurological disorders. These approaches deliver robust expression of therapeutic genes, but are
Externí odkaz:
https://doaj.org/article/9fbd913e1ca140628395b010d8625840
Autor:
Luis Quintino, Angrit Namislo, Marcus Davidsson, Ludivine S. Breger, Patrick Kavanagh, Martino Avallone, Erika Elgstrand-Wettergren, Christina Isaksson, Cecilia Lundberg
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 29-39 (2018)
Regulation of therapeutic transgene expression can increase the safety of gene therapy interventions, especially when targeting critical organs such as the brain. Although several gene expression systems have been described, none of the current syste
Externí odkaz:
https://doaj.org/article/9302a85eb1ed493c8cb2b668494caab4
Autor:
Luis Quintino, Francesco Gubinelli, Livija Sarauskyte, Elin Arvidsson, Marcus Davidsson, Cecilia Lundberg, Andreas Heuer
Publikováno v:
Journal of Neuroscience Methods. 378:109640
The development of axonal pathology is a key characteristic of many neurodegenerative disease such as Parkinson's disease and Alzheimer's disease. With advanced disease progression, affected axons do display several signs of pathology such as swellin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30154152c07e71486a377e0a97221d09
https://doi.org/10.1016/j.jneumeth.2022.109640
https://doi.org/10.1016/j.jneumeth.2022.109640
Publikováno v:
Small Cities: Sustainability Studies in Community & Cultural Engagement; 2023, p131-153, 23p
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46269 (2012)
Regulating transgene expression in vivo by delivering oral drugs has been a long-time goal for the gene therapy field. A novel gene regulating system based on targeted proteasomal degradation has been recently developed. The system is based on a dest
Externí odkaz:
https://doaj.org/article/ede1238e80cc468291c620c3498024d3
Autor:
Patrick Kavanagh, Luis Quintino, Patricia Garcia Jareño, Ludivine S. Breger, Martino Avallone, Cecilia Lundberg, Marcus Lockowandt, Emil Brännstrom
Publikováno v:
Gene Therapy
Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca1f584e3057701294ff642cd5c5f93
https://doi.org/10.1038/s41434-018-0049-0
https://doi.org/10.1038/s41434-018-0049-0
Autor:
Cecilia Lundberg, Marcus Lockowandt, L. Zanetti, Irene Sebastianutto, M. A. Cenci, Ludivine S. Breger, Tim Fieblinger, Luis Quintino
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Dendritic regression of striatal spiny projection neurons (SPNs) is a pathological hallmark of Parkinson’s disease (PD). Here we investigate how chronic dopamine denervation and dopamine replacement with L-DOPA affect the morphology and physiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a6ea477a82a015ac29aff102013929
http://link.springer.com/article/10.1038/s41598-018-28273-5
http://link.springer.com/article/10.1038/s41598-018-28273-5