Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Luigia Rossi"'
Autor:
Sara Biagiotti, Barbara Canonico, Mattia Tiboni, Faiza Abbas, Elena Perla, Mariele Montanari, Michela Battistelli, Stefano Papa, Luca Casettari, Luigia Rossi, Michele Guescini, Mauro Magnani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Extracellular vesicles (EVs) are promising natural nanocarriers for the delivery of therapeutic agents. As with any other kind of cell, red blood cells (RBCs) produce a limited number of EVs under physiological and pathological conditions. T
Externí odkaz:
https://doaj.org/article/bb826e0143ea47b5a5eb27d8dc5b53fe
Autor:
Marzia Bianchi, Luigia Rossi, Francesca Pierigè, Pietro De Angeli, Mattia Paolo Aliano, Claudia Carducci, Emanuele Di Carlo, Tiziana Pascucci, Francesca Nardecchia, Vincenzo Leuzzi, Mauro Magnani
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 26-40 (2022)
Here we report, for the first time, the engineering of human red blood cells (RBCs) with an entire metabolic pathway as a potential strategy to treat patients with guanidinoacetate methyltransferase (GAMT) deficiency, capable of reducing the high tox
Externí odkaz:
https://doaj.org/article/072330cee6434a5fa288ce93803cac8c
Autor:
Alessandro Bregalda, Claudia Carducci, Maria Teresa Viscomi, Francesca Pierigè, Sara Biagiotti, Michele Menotta, Federica Biancucci, Tiziana Pascucci, Vincenzo Leuzzi, Mauro Magnani, Luigia Rossi
Publikováno v:
Neurobiology of Disease, Vol 180, Iss , Pp 106093- (2023)
Untreated phenylketonuria (PKU) patients and PKU animal models show hypomyelination in the central nervous system and white matter damages, which are accompanied by myelin basic protein (MBP) impairment. Despite many assumptions, the primary explanat
Externí odkaz:
https://doaj.org/article/ea2f98d722914820afd10ddc5e353fa0
Autor:
Sara Biagiotti, Faiza Abbas, Mariele Montanari, Chiara Barattini, Luigia Rossi, Mauro Magnani, Stefano Papa, Barbara Canonico
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 365 (2023)
The article is divided into several sections, focusing on extracellular vesicles’ (EVs) nature, features, commonly employed methodologies and strategies for their isolation/preparation, and their characterization/visualization. This work aims to gi
Externí odkaz:
https://doaj.org/article/378029e8d7694bedb53493216d73e34e
Autor:
Luigia Rossi, Francesca Pierigè, Marco Agostini, Noemi Bigini, Veronica Termopoli, Yingting Cai, Fang Zheng, Chang-Guo Zhan, Donald W. Landry, Mauro Magnani
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301, al
Externí odkaz:
https://doaj.org/article/11175c615f6b4940bff621ea6f7e36c3
Autor:
Michele Menotta, Sara Biagiotti, Chiara Spapperi, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Annarosa Soresina, Roberto Micheli, Mauro Magnani
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-7 (2017)
Abstract Background Ataxia Telangiectasia (AT) is a rare incurable genetic disease, caused by biallelic mutations in the Ataxia Telangiectasia-Mutated (ATM) gene. Treatment with glucocorticoid analogues has been shown to improve the neurological symp
Externí odkaz:
https://doaj.org/article/e8db8bd3c8c94f99bffffefa4e97cd51
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Red blood cells (RBC) are actually exploited as innovative drug delivery systems with unconventional and convenient properties. Because of a long in vivo survival and a non-random removal from circulation, RBC can be loaded with drugs and/or contrast
Externí odkaz:
https://doaj.org/article/c0edf7f0d9b34d24b161c54fbc47cbc3
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216668 (2019)
Oxidative stress has been shown to play a crucial role in the pathophysiology of the neurodegenerative disease Ataxia Telangiectasia. We have recently demonstrated that Dexamethasone treatment is able to counteract the oxidative state by promoting nu
Externí odkaz:
https://doaj.org/article/fa0b08b0369d4b678fc9620590b45b53
Autor:
Raffaella Sabatino, Antonella Antonelli, Serafina Battistelli, Reto Schwendener, Mauro Magnani, Luigia Rossi
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e101260 (2014)
Bisphosphonates, besides being important drugs for the treatment of various bone diseases, could also be used to induce apoptosis in macrophage-like and cancer cells. However, their activity in vivo is limited by a short plasma half-life and rapid up
Externí odkaz:
https://doaj.org/article/56be3593f83b4891b7e1e408295e6da1
Publikováno v:
Expert Opinion on Drug Delivery. 18:43-54
Therapeutic enzymes are currently used in the treatment of several diseases. In most cases, the benefits are limited due to poorAmong the delivery systems, we focused on red blood cells for the delivery of therapeutic enzymes. Erythrocytes possess a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c399f146d8057d19d37f83c6e93468f7
https://doi.org/10.1080/17425247.2020.1822320
https://doi.org/10.1080/17425247.2020.1822320