Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Luigia, Pace"'
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Autor:
Lucía López, Luciano Gastón Morosi, Federica La Terza, Pierre Bourdely, Giuseppe Rospo, Roberto Amadio, Giulia Maria Piperno, Valentina Russo, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Luigia Pace, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presenting cDC1 and the potential of DC-based therapies in
Externí odkaz:
https://doaj.org/article/f7c6a9ff87e544acbdd02715c577e12b
Autor:
Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, Allan Thiolat, Rodrigo Nalio Ramos, Pamela Caudana, Jordan Denizeau, Ludovic Colombeau, Raphaël Rodriguez, Christel Goudot, Jean-Michel Luccarini, Anne Soudé, Bruno Bournique, Pierre Broqua, Luigia Pace, Sylvain Baulande, Christine Sedlik, Jean-Pierre Quivy, Geneviève Almouzni, José L. Cohen, Elina Zueva, Joshua J. Waterfall, Sebastian Amigorena, Eliane Piaggio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletely understood. We show here that genetic ablation or pharmac
Externí odkaz:
https://doaj.org/article/22bfa2b345944a4983ce8b49f08339e4
Autor:
Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, Allan Thiolat, Rodrigo Nalio Ramos, Pamela Caudana, Jordan Denizeau, Ludovic Colombeau, Raphaël Rodriguez, Christel Goudot, Jean-Michel Luccarini, Anne Soudé, Bruno Bournique, Pierre Broqua, Luigia Pace, Sylvain Baulande, Christine Sedlik, Jean-Pierre Quivy, Geneviève Almouzni, José L. Cohen, Elina Zueva, Joshua J. Waterfall, Sebastian Amigorena, Eliane Piaggio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/103f997df819424ea57c7cf97b5024dc
Publikováno v:
Biology Direct, Vol 15, Iss 1, Pp 1-11 (2020)
Abstract Knowing the “point of view” of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsible for the Coronavirus Disea
Externí odkaz:
https://doaj.org/article/2e066cae1a3d4bb9b3ad4116c285f3d0
Autor:
Luigia, Pace
Publikováno v:
Cold Spring Harbor perspectives in biology. 13(12)
Immunological memory is a fundamental hallmark of the adaptive immune responses and one of the most relevant aspects of protective immunity. Our understanding of the processes of memory T-cell differentiation and maintenance of long-term immunity is
Autor:
Gaia Montacchiesi, Luigia Pace
Publikováno v:
Immunological Reviews. 305:77-89
Autor:
Anna Morena, D'Alise, Nadia, Brasu, Carlo, De Intinis, Guido, Leoni, Valentina, Russo, Francesca, Langone, Denis, Baev, Elisa, Micarelli, Luca, Petiti, Simone, Picelli, Marwan, Fakih, Dung T, Le, Michael J, Overman, Anthony F, Shields, Katrina S, Pedersen, Manish A, Shah, Sarbajit, Mukherjee, Thea, Faivre, Patricia, Delaite, Elisa, Scarselli, Luigia, Pace
Publikováno v:
Sci Transl Med
Upon chronic antigen exposure, CD8(+) T cells become exhausted, acquiring a dysfunctional state correlated with the inability to control infection or tumor progression. In contrast, stem-like CD8(+) T progenitors maintain the ability to promote and s
Autor:
Catharina Arnold-Schrauf, Markus Dudek, Anastasia Dielmann, Luigia Pace, Maxine Swallow, Friederike Kruse, Anja A. Kühl, Bernhard Holzmann, Luciana Berod, Tim Sparwasser
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 698-708 (2014)
Listeria monocytogenes (LM), a facultative intracellular Gram-positive pathogen, can cause life-threatening infections in humans. In mice, the signaling cascade downstream of the myeloid differentiation factor 88 (MyD88) is essential for proper innat
Externí odkaz:
https://doaj.org/article/94ae797c90cc441fa27970ede8d378e9
Autor:
Nadia, Brasu, Ines, Elia, Valentina, Russo, Gaia, Montacchiesi, Simona Aversano, Stabile, Carlo, De Intinis, Francesco, Fesi, Katiuscia, Gizzi, Marco, Macagno, Monica, Montone, Benedetta, Mussolin, Alba, Grifoni, Silvia, Faravelli, Silvia, Marchese, Federico, Forneris, Raffaele, De Francesco, Alessandro, Sette, Vincenzo, Barnaba, Antonino, Sottile, Anna, Sapino, Luigia, Pace
Publikováno v:
Nature immunology. 23(10)
Understanding immune responses to SARS-CoV-2 messenger RNA (mRNA) vaccines is of great interest, principally because of the poor knowledge about the mechanisms of protection. In the present study, we analyzed longitudinally B cell and T cell memory p
Autor:
Nadia Brasu, Ines Elia, Valentina Russo, Gaia Montacchiesi, Simona Aversano Stabile, Carlo De Intinis, Francesco Fesi, Katiuscia Gizzi, Marco Macagno, Monica Montone, Benedetta Mussolin, Alba Grifoni, Silvia Faravelli, Silvia Marchese, Federico Forneris, Raffaele De Francesco, Alessandro Sette, Vincenzo Barnaba, Antonino Sottile, Anna Sapino, Luigia Pace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaeae9da5bbede174597f3d070ae80e
https://hdl.handle.net/2318/1885966
https://hdl.handle.net/2318/1885966