Zobrazeno 1 - 10
of 406
pro vyhledávání: '"Luigi Messori"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The possibility of using selectively incorporated 19F nuclei for NMR spectroscopic studies has retrieved increasing interest in recent years. The high gyromagnetic ratio of 19F and its absence in native biomolecular systems make this nucleus
Externí odkaz:
https://doaj.org/article/f26168189fa9428f8b88f9924f28af3f
Autor:
Francesca Coscione, Stefano Zineddu, Valentina Vitali, Marco Fondi, Luigi Messori, Elena Perrin
Publikováno v:
Antibiotics, Vol 13, Iss 7, p 652 (2024)
Auranofin (AF) is a gold-based compound with a well-known pharmacological and toxicological profile, currently used in the treatment of some severe forms of rheumatoid arthritis. Over the last twenty years, AF has also been repurposed as antiviral, a
Externí odkaz:
https://doaj.org/article/60c36dc103d945b4a605561b7aa14c86
Autor:
Damiano Cirri, Tiziano Marzo, Piero Mastrorilli, Valentina Petrelli, Stefano Todisco, Elvira De Giglio, Cristina Gellini, Marilena Ricci, Alessandro Pratesi, Luigi Messori
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7408 (2024)
The peculiar behavior of arsenoplatin-1, ([Pt(µ-NHC(CH3)O)2ClAs(OH)2], AP-1), in aqueous solution and the progressive appearance of a characteristic and intense blue color led us to carry out a more extensive investigation to determine the nature of
Externí odkaz:
https://doaj.org/article/9a33fc974dc8442ca5a8242575a4f102
Publikováno v:
Molecules, Vol 28, Iss 13, p 5196 (2023)
Gold compounds form a new class of promising anticancer agents with innovative modes of action. It is generally believed that anticancer gold compounds, at variance with clinically established platinum drugs, preferentially target proteins rather tha
Externí odkaz:
https://doaj.org/article/447423d89cd740e0b734fd030c9e4afb
Autor:
Giovanni Chiappetta, Tania Gamberi, Fiorella Faienza, Xhesika Limaj, Salvatore Rizza, Luigi Messori, Giuseppe Filomeni, Alessandra Modesti, Joelle Vinh
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102294- (2022)
The effects of Auranofin (AF) on protein expression and protein oxidation in A2780 cancer cells were investigated through a strategy based on simultaneous expression proteomics and redox proteomics determinations. Bioinformatics analysis of the prote
Externí odkaz:
https://doaj.org/article/7eb4262de80b4b418a84168123ed4a6c
Autor:
Damiano Cirri, Andrea Geri, Lara Massai, Michele Mannelli, Tania Gamberi, Francesca Magherini, Matteo Becatti, Chiara Gabbiani, Alessandro Pratesi, Luigi Messori
Publikováno v:
Molecules, Vol 28, Iss 3, p 1050 (2023)
A panel of four novel gold(I) complexes, inspired by the clinically established gold drug auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate), was prepared and characterized. All these compounds feature the replacement
Externí odkaz:
https://doaj.org/article/e22689add0cd4e5199ce0c17ae1bbaba
Autor:
Lara Massai, Deborah Grifagni, Alessia De Santis, Andrea Geri, Francesca Cantini, Vito Calderone, Lucia Banci, Luigi Messori
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1675 (2022)
Gold compounds have a long tradition in medicine and offer many opportunities for new therapeutic applications. Herein, we evaluated the lead compound Auranofin and five related gold(I) complexes as possible inhibitors of SARS-CoV-2 Main Protease (SA
Externí odkaz:
https://doaj.org/article/a3ea0616ea5a4d1899af8596752ff674
Autor:
Rosanna Lucignano, Alessandro Pratesi, Paola Imbimbo, Daria Maria Monti, Delia Picone, Luigi Messori, Giarita Ferraro, Antonello Merlino
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14162 (2022)
Auranofin (AF), a gold(I) compound that is currently used for the treatment of rheumatoid arthritis and is in clinical trials for its promising anticancer activity, was encapsulated within the human H-chain and the horse spleen ferritin nanocages usi
Externí odkaz:
https://doaj.org/article/1b902e3e237d4fb4be10b626ed3973d0
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Electrospray ionization mass spectrometry (ESI MS) is a powerful investigative tool to analyze the reactions of metallodrugs with proteins and peptides and characterize the resulting adducts. Here, we have applied this type of approach to four experi
Externí odkaz:
https://doaj.org/article/69a7a083dc08423cb61629487d334d31
Autor:
Iogann Tolbatov, Damiano Cirri, Lorella Marchetti, Alessandro Marrone, Cecilia Coletti, Nazzareno Re, Diego La Mendola, Luigi Messori, Tiziano Marzo, Chiara Gabbiani, Alessandro Pratesi
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Au(PEt3)I (AF-I hereafter), the iodide analog of the FDA-approved drug auranofin (AF hereafter), is a promising anticancer agent that produces its pharmacological effects through interaction with non-genomic targets such as the thioredoxin reductase
Externí odkaz:
https://doaj.org/article/80d53dd7b0e24fbabdfa02fc233254b9