Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Luigi Marchionni"'
A triple hormone receptor ER, AR, and VDR signature is a robust prognosis predictor in breast cancer
Autor:
Mohamed Omar, J. Chuck Harrell, Rulla Tamimi, Luigi Marchionni, Cihat Erdogan, Harikrishna Nakshatri, Tan A. Ince
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-16 (2024)
Abstract Background Despite evidence indicating the dominance of cell-of-origin signatures in molecular tumor patterns, translating these genome-wide patterns into actionable insights has been challenging. This study introduces breast cancer cell-of-
Externí odkaz:
https://doaj.org/article/8a2eb70994dd4c63a4786f5a0770dfac
Autor:
Hannah E. Bergom, Laura A. Sena, Abderrahman Day, Benjamin Miller, Carly D. Miller, John R. Lozada, Nicholas Zorko, Jinhua Wang, Eugene Shenderov, Francisco Pereira Lobo, Fernanda Caramella-Pereira, Luigi Marchionni, Charles G. Drake, Tamara Lotan, Angelo M. De Marzo, Justin Hwang, Emmanuel S. Antonarakis
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract Patients with prostate cancer (PC) generally do not respond favorably to immune checkpoint inhibitors, which may be due to a low abundance of tumor-infiltrating lymphocytes even when mutational load is high. Here, we identified a patient who
Externí odkaz:
https://doaj.org/article/a63fc47e643a46939677c01b1b4e10df
Autor:
Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular
Externí odkaz:
https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Structural variants (SVs) represent a major source of genetic variation associated with phenotypic diversity and disease susceptibility. While long-read sequencing can discover over 20,000 SVs per human genome, interpreting their functional
Externí odkaz:
https://doaj.org/article/69c5733a1e94481db574e3e023acf195
Autor:
Mohamed Omar, Pier Vitale Nuzzo, Francesco Ravera, Sara Bleve, Giuseppe Nicolò Fanelli, Claudio Zanettini, Itzel Valencia, Luigi Marchionni
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background While the efficacy of neoadjuvant chemotherapy (NACT) in treating triple-negative breast cancer (TNBC) is generally accepted, not all patients derive benefit from this preoperative treatment. Presently, there are no validated biom
Externí odkaz:
https://doaj.org/article/39b7d25a562741d39b649e27996bc224
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Alternative polyadenylation (APA) is an important post-transcriptional mechanism that has major implications in biological processes and diseases. Although specialized sequencing methods for polyadenylation exist, availability of these data
Externí odkaz:
https://doaj.org/article/7e968b6a62e94e5794bc75f7fce5eadb
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Tumor phenotype is shaped both by transforming genomic alterations and the normal cell-of-origin. We identified a cell-of-origin associated prognostic gene expression signature, ET-9, that correlates with remarkably shorter overall and relap
Externí odkaz:
https://doaj.org/article/ef80417291074b909ff6c761bbe01a3f
Autor:
Jorge Augusto Hongo, Giovanni Marques de Castro, Alison Pelri Albuquerque Menezes, Agnello César Rios Picorelli, Thieres Tayroni Martins da Silva, Eddie Luidy Imada, Luigi Marchionni, Luiz-Eduardo Del-Bem, Anderson Vieira Chaves, Gabriel Magno de Freitas Almeida, Felipe Campelo, Francisco Pereira Lobo
Publikováno v:
Patterns, Vol 4, Iss 6, Pp 100728- (2023)
Summary: Living species vary significantly in phenotype and genomic content. Sophisticated statistical methods linking genes with phenotypes within a species have led to breakthroughs in complex genetic diseases and genetic breeding. Despite the abun
Externí odkaz:
https://doaj.org/article/f377a160f342482fa8d508f3113c3d85
Autor:
Mohamed Omar, Wikum Dinalankara, Lotte Mulder, Tendai Coady, Claudio Zanettini, Eddie Luidy Imada, Laurent Younes, Donald Geman, Luigi Marchionni
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106108- (2023)
Summary: Many gene signatures have been developed by applying machine learning (ML) on omics profiles, however, their clinical utility is often hindered by limited interpretability and unstable performance. Here, we show the importance of embedding p
Externí odkaz:
https://doaj.org/article/8a3e5baaa316431e8578ac630a4a2d8a
Autor:
Thiago Vidotto, Eddie L. Imada, Farzana Faisal, Sanjana Murali, Adrianna A. Mendes, Harsimar Kaur, Siqun Zheng, Jianfeng Xu, Edward M. Schaeffer, William B. Isaacs, Karen S. Sfanos, Luigi Marchionni, Tamara L. Lotan
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
The genomic and immune landscapes of prostate cancer differ by self-identified race. However, few studies have examined the genome-wide copy number landscape and immune content of matched cohorts with genetic ancestry data and clinical outcomes. Here
Externí odkaz:
https://doaj.org/article/ecd843645058485e9f5dc48d24f26852